Department of Molecular Pharmacology

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#	Title	Journal	Year	Citations
1	The tor pathway: a target for cancer therapy	Nature Reviews Cancer	2004	1,255
2	The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance	Science	2002	574
3	Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks	Journal of Cell Biology	2006	564
4	mTOR and cancer therapy	Oncogene	2006	436
5	The pediatric preclinical testing program: Description of models and early testing results	Pediatric Blood and Cancer	2007	430
6	Establishment of human tumor xenografts in immunodeficient mice	Nature Protocols	2007	413
7	Targeting mTOR signaling for cancer therapy	Current Opinion in Pharmacology	2003	411
8	Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors	Cancer Chemotherapy and Pharmacology	1995	331
9	Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro	Cancer Research	2004	312
10	Rapamycins: Mechanisms of Action and Cellular Resistance	Cancer Biology and Therapy	2003	282
11	Stem and progenitor cell-mediated tumor selective gene therapy	Gene Therapy	2008	261
12	Potentiation of neuroblastoma metastasis by loss of caspase-8	Nature	2006	256
13	Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells	Cancer Research	1999	253
14	Sustained Activation of the JNK Cascade and Rapamycin-Induced Apoptosis Are Suppressed by p53/p21Cip1	Molecular Cell	2003	218
15	In vivo selection of retrovirally transduced hematopoietic stem cells	Nature Medicine	1998	205
16	Cloning of the Human Equilibrative, Nitrobenzylmercaptopurine Riboside (NBMPR)-insensitive Nucleoside Transporter ei by Functional Expression in a Transport-deficient Cell Line	Journal of Biological Chemistry	1998	204
17	Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme	Nature Structural and Molecular Biology	2003	195
18	Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development	European Journal of Cancer	2004	195
19	Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition	Clinical Cancer Research	2001	195
20	Amino Acid-dependent Control of p70s6k	Journal of Biological Chemistry	1999	190
21	Keynote review: Mammalian carboxylesterases: From drug targets to protein therapeutics	Drug Discovery Today	2005	190
22	Alternative and aberrant splicing of MDM2 mRNA in human cancer	Cancer Cell	2002	182
23	Lost in translation	Cancer Cell	2004	176
24	Hydrolysis of pyrethroids by human and rat tissues: Examination of intestinal, liver and serum carboxylesterases	Toxicology and Applied Pharmacology	2007	176
25	Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11	Cancer Research	1998	175
26	Antitopoisomerase drug action and resistance	European Journal of Cancer	1996	171
27	Strong Immunostaining for Myogenin in Rhabdomyosarcoma Is Significantly Associated with Tumors of the Alveolar Subclass	American Journal of Pathology	2000	166
28	Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells	Molecular Pharmacology	1998	162
29	Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene	Cancer Research	1997	154
30	Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases	Biochemical Pharmacology	2006	151
31	Thymineless death in colon carcinoma cells is mediated via Fas signaling	Proceedings of the National Academy of Sciences of the United States of America	1997	150
32	Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage	Proceedings of the National Academy of Sciences of the United States of America	2006	147
33	Structural insights into CPT-11 activation by mammalian carboxylesterases	Nature Structural Biology	2002	144
34	Carboxylesterases - Detoxifying Enzymes and Targets for Drug Therapy	Current Medicinal Chemistry	2006	135
35	Multisite Promiscuity in the Processing of Endogenous Substrates by Human Carboxylesterase 1	Journal of Molecular Biology	2006	128
36	DNA Topoisomerase II as a Target for Cancer Chemotherapy	Cancer Investigation	2002	127
37	Tumor-Targeted Enzyme/Prodrug Therapy Mediates Long-term Disease-Free Survival of Mice Bearing Disseminated Neuroblastoma	Cancer Research	2007	127
38	Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitutions of Leucine 22	Journal of Biological Chemistry	1995	126
39	Mechanisms of resistance to rapamycins	Drug Resistance Updates	2001	123
40	Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor	Cancer Research	1994	118
41	Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin	Cancer Research	1993	116
42	Proficient metabolism of irinotecan by a human intestinal carboxylesterase	Cancer Research	2000	116
43	Protection and in Vivo Selection of Hematopoietic Stem Cells Using Temozolomide, O6-Benzylguanine, and an Alkyltransferase-Expressing Retroviral Vector	Molecular Therapy	2001	113
44	p53 mutation and MDM2 amplification frequency in pediatric rhabdomyosarcoma tumors and cell lines	Medical and Pediatric Oncology	2000	112
45	Predominant Nuclear Localization of Mammalian Target of Rapamycin in Normal and Malignant Cells in Culture	Journal of Biological Chemistry	2002	111
46	IGF-I mediated survival pathways in normal and malignant cells	Biochimica Et Biophysica Acta: Reviews on Cancer	2006	111
47	Development of a Tumor-Selective Approach to Treat Metastatic Cancer	PLoS ONE	2006	111
48	Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA	Molecular Pharmacology	1996	110
49	p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin	Cancer Research	2001	109
50	The molecular basis of skeletal muscle differentiation	Seminars in Diagnostic Pathology	1994	105

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