| PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting | Nature Reviews Cancer | 2015 | 825 |
| Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair | Nature | 2015 | 451 |
| A comparison of non-integrating reprogramming methods | Nature Biotechnology | 2015 | 326 |
| CDK7-dependent transcriptional addiction in triple-negative breast cancer | Cell | 2015 | 268 |
| EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors | Clinical Cancer Research | 2015 | 256 |
| Hallmarks of pluripotency | Nature | 2015 | 253 |
| Bioprinting for cancer research | Trends in Biotechnology | 2015 | 239 |
| Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes | Nature Communications | 2015 | 230 |
| Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch | Developmental Cell | 2015 | 184 |
| Light-triggered, self-immolative nucleic Acid-drug nanostructures | Journal of the American Chemical Society | 2015 | 157 |
| Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer | Cancer Cell | 2015 | 137 |
| Transcriptional Landscape of Cardiomyocyte Maturation | Cell Reports | 2015 | 95 |
| EPHA2 is a mediator of vemurafenib resistance and a novel therapeutic target in melanoma | Cancer Discovery | 2015 | 77 |
| Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis | Molecular Systems Biology | 2015 | 66 |
| Mutations in G protein β subunits promote transformation and kinase inhibitor resistance | Nature Medicine | 2015 | 60 |
| The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells | Nature Medicine | 2015 | 60 |
| Metabolic switches linked to pluripotency and embryonic stem cell differentiation | Cell Metabolism | 2015 | 58 |
| Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines | Molecular Oncology | 2015 | 43 |
| Pre-TCR ligand binding impacts thymocyte development before αβTCR expression | Proceedings of the National Academy of Sciences of the United States of America | 2015 | 41 |
| Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence | Journal of Experimental Medicine | 2015 | 40 |
| Stem cells and the evolving notion of cellular identity | Philosophical Transactions of the Royal Society B: Biological Sciences | 2015 | 40 |
| Development of small molecules targeting the pseudokinase Her3 | Bioorganic and Medicinal Chemistry Letters | 2015 | 38 |
| Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region | Structure | 2015 | 37 |
| Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor | ACS Medicinal Chemistry Letters | 2015 | 34 |
| Failure to replicate the STAP cell phenomenon | Nature | 2015 | 34 |
