| # | Title | Journal | Year | Citations |
|---|
| 1 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,937 |
| 2 | THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES 1 | Journal of Clinical Investigation | 1948 | 1,860 |
| 3 | A circadian gene expression atlas in mammals: Implications for biology and medicine | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 1,802 |
| 4 | THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN 1 | Journal of Clinical Investigation | 1948 | 1,664 |
| 5 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 6 | Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow | Cell | 2006 | 1,211 |
| 7 | ATP and Brain Function | Journal of Cerebral Blood Flow and Metabolism | 1989 | 756 |
| 8 | Understanding multicellular function and disease with human tissue-specific networks | Nature Genetics | 2015 | 738 |
| 9 | Metabolism and role of glutamate in mammalian brain | Progress in Neurobiology | 1990 | 640 |
| 10 | An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans | Diabetes | 2017 | 615 |
| 11 | Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers | Cancer Cell | 2015 | 601 |
| 12 | Classification and nomenclature of somatostatin receptors | Trends in Pharmacological Sciences | 1995 | 537 |
| 13 | Control of Endothelial Targeting and Intracellular Delivery of Therapeutic Enzymes by Modulating the Size and Shape of ICAM-1-targeted Carriers | Molecular Therapy | 2008 | 506 |
| 14 | C3 glomerulopathy: consensus report | Kidney International | 2013 | 505 |
| 15 | Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice | Nature Medicine | 1998 | 496 |
| 16 | Maternal High-Fat Diet Alters Methylation and Gene Expression of Dopamine and Opioid-Related Genes | Endocrinology | 2010 | 494 |
| 17 | 5-HT1A receptor function in major depressive disorder | Progress in Neurobiology | 2009 | 482 |
| 18 | Interactions of polyamines with ion channels | Biochemical Journal | 1997 | 445 |
| 19 | Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation | Journal of Cell Biology | 1998 | 440 |
| 20 | Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro | Neuron | 1993 | 431 |
| 21 | Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production | Gut | 2016 | 428 |
| 22 | Ions and energy in mammalian brain | Progress in Neurobiology | 1994 | 413 |
| 23 | Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis | Nature Genetics | 2012 | 402 |
| 24 | Regulation of cellular energy metabolism | Journal of Membrane Biology | 1982 | 401 |
| 25 | Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation in vitro | Human Molecular Genetics | 1999 | 386 |
| 26 | A new view of transcriptome complexity and regulation through the lens of local splicing variations | ELife | 2016 | 385 |
| 27 | Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening | Current Biology | 2009 | 368 |
| 28 | Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci | Nature Genetics | 2015 | 365 |
| 29 | The oxygen dependence of cellular energy metabolism | Archives of Biochemistry and Biophysics | 1979 | 351 |
| 30 | Oxidative injury in diseases of the central nervous system: focus on alzheimer’s disease | American Journal of Medicine | 2000 | 349 |
| 31 | The aldo-keto reductases (AKRs): Overview | Chemico-Biological Interactions | 2015 | 348 |
| 32 | Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion | Molecular Cell | 2014 | 347 |
| 33 | Extensive Variation in Chromatin States Across Humans | Science | 2013 | 338 |
| 34 | STUDIES ON THE ESTIMATION OF CARDIAC OUPTUT IN MAN, AND OF ABNORMALITIES IN CARDIAC FUNCTION, FROM THE HEART'S RECOIL AND THE BLOOD'S IMPACTS; THE BALLISTOCARDIOGRAM | American Journal of Physiology | 1939 | 337 |
| 35 | A Distinct Role for Norepinephrine in Memory Retrieval | Cell | 2004 | 336 |
| 36 | Adult hippocampal neurogenesis: Regulation, functional implications, and contribution to disease pathology | Neuroscience and Biobehavioral Reviews | 2009 | 333 |
| 37 | Modulation of the NMDA receptor by polyamines | Life Sciences | 1991 | 313 |
| 38 | N-methyl-D-aspartate Receptor Subtypes: Multiple Roles in Excitotoxicity and Neurological Disease | Neuroscientist | 2005 | 313 |
| 39 | cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs | Journal of Neuroscience | 2002 | 307 |
| 40 | Timing of cyclin D1 expression within G1 phase is controlled by Rho | Nature Cell Biology | 2001 | 298 |
| 41 | Prevention of postdural puncture headache after accidental dural puncture: a quantitative systematic review | British Journal of Anaesthesia | 2010 | 286 |
| 42 | A system for characterizing cellular and molecular events in programmed neuronal cell death | Journal of Neuroscience | 1993 | 284 |
| 43 | Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells | ACS Nano | 2013 | 276 |
| 44 | Direct Protein Kinase C-dependent Phosphorylation Regulates the Cell Surface Stability and Activity of the Potassium Chloride Cotransporter KCC2 | Journal of Biological Chemistry | 2007 | 272 |
| 45 | Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility | Neuron | 2016 | 272 |
| 46 | The promise of single-cell sequencing | Nature Methods | 2014 | 262 |
| 47 | N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells | Nature Materials | 2016 | 262 |
| 48 | Increased nucleotide excision repair in cisplatin-resistant ovarian cancer cells | Biochemical Pharmacology | 2000 | 260 |
| 49 | Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain | Annals of Neurology | 1997 | 250 |
| 50 | A New General Concept of the Neurohumoral Functions of Acetylcholine and Acetylcholinesterase | Journal of Pharmacy and Pharmacology | 2011 | 250 |
