| # | Title | Journal | Year | Citations |
|---|
| 1 | Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene | Nature | 1996 | 2,782 |
| 2 | A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors | Cell | 1996 | 1,967 |
| 3 | Tau-mediated neurodegeneration in Alzheimer's disease and related disorders | Nature Reviews Neuroscience | 2007 | 1,866 |
| 4 | Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response | Nature | 2018 | 1,836 |
| 5 | CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms | Molecular and Cellular Biology | 2005 | 1,609 |
| 6 | BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis | Molecular Cell | 2001 | 1,535 |
| 7 | Chimeric Antigen Receptor Therapy | New England Journal of Medicine | 2018 | 1,488 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 9 | Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria | Movement Disorders | 2017 | 1,402 |
| 10 | Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo | Science | 1988 | 1,387 |
| 11 | T-cell invigoration to tumour burden ratio associated with anti-PD-1 response | Nature | 2017 | 1,280 |
| 12 | Guidelines on the Use of Therapeutic Apheresis in Clinical Practice – Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis: The Eighth Special Issue | Journal of Clinical Apheresis | 2019 | 1,263 |
| 13 | Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS | Nature | 2013 | 1,249 |
| 14 | Immune Thrombocytopenic Purpura | New England Journal of Medicine | 2002 | 1,237 |
| 15 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
| 16 | The CD28 Signaling Pathway Regulates Glucose Metabolism | Immunity | 2002 | 1,201 |
| 17 | Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia | Nature Medicine | 2018 | 1,150 |
| 18 | A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma | Science Translational Medicine | 2017 | 1,116 |
| 19 | Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS | Neuron | 2010 | 1,100 |
| 20 | Analysis of shared heritability in common disorders of the brain | Science | 2018 | 1,085 |
| 21 | Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells | Nature | 2011 | 1,071 |
| 22 | Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin | Nature Immunology | 2005 | 1,055 |
| 23 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 24 | Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster | Nature Genetics | 2006 | 1,000 |
| 25 | Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo | Molecular Therapy | 2009 | 988 |
| 26 | Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors | Nature Biotechnology | 2005 | 967 |
| 27 | TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion | Nature | 2019 | 934 |
| 28 | Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma | Blood | 2013 | 932 |
| 29 | Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology | Nature Clinical Practice Cardiovascular Medicine | 2009 | 918 |
| 30 | ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models | Science | 2012 | 913 |
| 31 | Common genetic variants on 5p14.1 associate with autism spectrum disorders | Nature | 2009 | 912 |
| 32 | Treatment of Leber Congenital Amaurosis Due toRPE65Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial | Human Gene Therapy | 2008 | 880 |
| 33 | Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 | Nature Immunology | 2010 | 878 |
| 34 | Deacetylase inhibition promotes the generation and function of regulatory T cells | Nature Medicine | 2007 | 835 |
| 35 | Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade | Cell | 2016 | 830 |
| 36 | Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways | Science | 2015 | 823 |
| 37 | Molecular basis of phenotypic variability in sporadc creudeldt-jakob disease | Annals of Neurology | 1996 | 819 |
| 38 | Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells | Immunity | 2016 | 811 |
| 39 | NIX is required for programmed mitochondrial clearance during reticulocyte maturation | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 768 |
| 40 | Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry | Blood | 1987 | 750 |
| 41 | Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors | Nature Medicine | 2014 | 742 |
| 42 | Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 734 |
| 43 | A new classification for HIV-1 | Nature | 1998 | 733 |
| 44 | New insights into the genetic etiology of Alzheimer’s disease and related dementias | Nature Genetics | 2022 | 700 |
| 45 | American Society of Hematology 2019 guidelines for immune thrombocytopenia | Blood Advances | 2019 | 684 |
| 46 | Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images | Cell Reports | 2018 | 683 |
| 47 | Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer | Nature Immunology | 2008 | 675 |
| 48 | The ITP syndrome: pathogenic and clinical diversity | Blood | 2009 | 662 |
| 49 | PD‐1 signaling in primary T cells | Immunological Reviews | 2009 | 655 |
| 50 | Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis | Nature Medicine | 2000 | 651 |
