| # | Title | Journal | Year | Citations |
|---|
| 1 | Cohesin mediates transcriptional insulation by CCCTC-binding factor | Nature | 2008 | 1,050 |
| 2 | Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 924 |
| 3 | AAA+superfamily ATPases: common structure-diverse function | Genes To Cells | 2001 | 864 |
| 4 | α-Catenin as a tension transducer that induces adherens junction development | Nature Cell Biology | 2010 | 864 |
| 5 | Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis | Journal of Biological Chemistry | 2003 | 783 |
| 6 | Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells | Cell Stem Cell | 2014 | 725 |
| 7 | Hippo pathway regulation by cell morphology and stress fibers | Development (Cambridge) | 2011 | 707 |
| 8 | DNA Methylation Is a Critical Cell-Intrinsic Determinant of Astrocyte Differentiation in the Fetal Brain | Developmental Cell | 2001 | 570 |
| 9 | Dopamine Is a Regulator of Arousal in the Fruit Fly | Journal of Neuroscience | 2005 | 502 |
| 10 | Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination | EMBO Journal | 2004 | 499 |
| 11 | Sall1 is a transcriptional regulator defining microglia identity and function | Nature Immunology | 2016 | 430 |
| 12 | Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells | Cell Metabolism | 2014 | 421 |
| 13 | Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc | Nature Communications | 2012 | 357 |
| 14 | Polarity-Dependent Distribution of Angiomotin Localizes Hippo Signaling in Preimplantation Embryos | Current Biology | 2013 | 352 |
| 15 | BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 333 |
| 16 | Higher-Order Kidney Organogenesis from Pluripotent Stem Cells | Cell Stem Cell | 2017 | 320 |
| 17 | Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice | Journal of Biological Chemistry | 2004 | 298 |
| 18 | Brain from bone: Efficient “meta-differentiation” of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent | Differentiation | 2001 | 292 |
| 19 | Molecular architecture of adherens junctions | Current Opinion in Cell Biology | 2001 | 290 |
| 20 | Identification of a dopamine pathway that regulates sleep and arousal in Drosophila | Nature Neuroscience | 2012 | 281 |
| 21 | Head and backbone of the Early Cambrian vertebrate Haikouichthys | Nature | 2003 | 280 |
| 22 | Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex | Molecular and Cellular Biology | 2002 | 250 |
| 23 | CTCF-Dependent Chromatin Insulator Is Linked to Epigenetic Remodeling | Molecular Cell | 2006 | 249 |
| 24 | The murine homolog ofSALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates withSall1in anorectal, heart, brain and kidney development | Development (Cambridge) | 2006 | 241 |
| 25 | Methyl-CpG Binding Domain 1 (MBD1) Interacts with the Suv39h1-HP1 Heterochromatic Complex for DNA Methylation-based Transcriptional Repression | Journal of Biological Chemistry | 2003 | 237 |
| 26 | Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases | Journal of Structural Biology | 2004 | 233 |
| 27 | Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines | Development (Cambridge) | 2001 | 230 |
| 28 | Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells | Biochemical and Biophysical Research Communications | 2006 | 221 |
| 29 | Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4 | Molecular and Cellular Biology | 1999 | 220 |
| 30 | Identification of Multiple Novel Epididymis-Specific β-Defensin Isoforms in Humans and Mice | Journal of Immunology | 2002 | 220 |
| 31 | Behavioral consequences of dopamine deficiency in the Drosophila central nervous system | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 220 |
| 32 | Visceral Endoderm Mediates Forebrain Development by Suppressing Posteriorizing Signals | Developmental Biology | 2000 | 203 |
| 33 | Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases | International Journal of Molecular Sciences | 2018 | 202 |
| 34 | Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation | American Journal of Pathology | 2012 | 194 |
| 35 | Crystal structure of thymine DNA glycosylase conjugated to SUMO-1 | Nature | 2005 | 193 |
| 36 | Sonic hedgehog is required for cardiac outflow tract and neural crest cell development | Developmental Biology | 2005 | 191 |
| 37 | Notch and Hippo Converge on Cdx2 to Specify the Trophectoderm Lineage in the Mouse Blastocyst | Developmental Cell | 2014 | 189 |
| 38 | Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells | Journal of Cell Biology | 2008 | 188 |
| 39 | Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro | PLoS ONE | 2013 | 188 |
| 40 | HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst | PLoS Genetics | 2014 | 186 |
| 41 | Human Induced Pluripotent Stem Cell–Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation | Journal of the American Society of Nephrology: JASN | 2016 | 186 |
| 42 | Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster | EMBO Journal | 2009 | 185 |
| 43 | Multiple roles of Rev3, the catalytic subunit of pol in maintaining genome stability in vertebrates | EMBO Journal | 2003 | 183 |
| 44 | The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis | Science Translational Medicine | 2017 | 182 |
| 45 | FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure | Nature Communications | 2012 | 181 |
| 46 | HMGA2 Maintains Oncogenic RAS-Induced Epithelial-Mesenchymal Transition in Human Pancreatic Cancer Cells | American Journal of Pathology | 2009 | 180 |
| 47 | H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation | Molecular Cell | 2015 | 180 |
| 48 | Interactions between Plexin-A2, Plexin-A4, and Semaphorin 6A Control Lamina-Restricted Projection of Hippocampal Mossy Fibers | Neuron | 2007 | 179 |
| 49 | Nedd4 Regulates Egress of Ebola Virus-Like Particles from Host Cells | Journal of Virology | 2003 | 173 |
| 50 | Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 170 |
