| # | Title | Journal | Year | Citations |
|---|
| 1 | Roles of CHOP/GADD153 in endoplasmic reticulum stress | Cell Death and Differentiation | 2004 | 2,440 |
| 2 | CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A target for novel cancer therapy | Cancer Treatment Reviews | 2018 | 867 |
| 3 | Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 | Nature | 2010 | 859 |
| 4 | Low-Dose Aspirin for Primary Prevention of Atherosclerotic Events in Patients With Type 2 Diabetes<subtitle>A Randomized Controlled Trial</subtitle> | JAMA - Journal of the American Medical Association | 2008 | 710 |
| 5 | Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake | Cell Metabolism | 2007 | 701 |
| 6 | Epithelial–mesenchymal transition in cancer development and its clinical significance | Cancer Science | 2010 | 691 |
| 7 | Possible involvement of the M2 anti‐inflammatory macrophage phenotype in growth of human gliomas | Journal of Pathology | 2008 | 663 |
| 8 | Aurora-A — A guardian of poles | Nature Reviews Cancer | 2005 | 655 |
| 9 | Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells | Cell | 2003 | 563 |
| 10 | Repurposing Diflunisal for Familial Amyloid Polyneuropathy | JAMA - Journal of the American Medical Association | 2013 | 551 |
| 11 | Origin of New Glial Cells in Intact and Injured Adult Spinal Cord | Cell Stem Cell | 2010 | 533 |
| 12 | Role of sensory neuron in reduction of endotoxin-induced hypotension in rats | Critical Care Medicine | 2005 | 526 |
| 13 | Guideline of transthyretin-related hereditary amyloidosis for clinicians | Orphanet Journal of Rare Diseases | 2013 | 525 |
| 14 | Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination | EMBO Journal | 2004 | 499 |
| 15 | Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy | Advanced Drug Delivery Reviews | 2016 | 469 |
| 16 | jPOSTrepo: an international standard data repository for proteomes | Nucleic Acids Research | 2017 | 451 |
| 17 | Clinical significance of macrophage heterogeneity in human malignant tumors | Cancer Science | 2014 | 425 |
| 18 | Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells | Cell Metabolism | 2014 | 421 |
| 19 | Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers | Cancer Immunology, Immunotherapy | 2007 | 413 |
| 20 | INNATE IMMUNE RESPONSE IN TH1- AND TH2-DOMINANT MOUSE STRAINS | Shock | 2004 | 409 |
| 21 | Keap1 degradation by autophagy for the maintenance of redox homeostasis | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 394 |
| 22 | Clinical impact of serum exosomal microRNA‐21 as a clinical biomarker in human esophageal squamous cell carcinoma | Cancer | 2013 | 391 |
| 23 | Abdominal CT with Low Tube Voltage: Preliminary Observations about Radiation Dose, Contrast Enhancement, Image Quality, and Noise | Radiology | 2005 | 388 |
| 24 | Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker | Biochemical and Biophysical Research Communications | 2003 | 385 |
| 25 | Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP | Cell Death and Differentiation | 2004 | 379 |
| 26 | Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration | Science | 2014 | 378 |
| 27 | Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics | Nature Communications | 2017 | 373 |
| 28 | Transthyretin-Related Familial Amyloidotic Polyneuropathy | Archives of Neurology | 2005 | 365 |
| 29 | Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle | Cell Metabolism | 2011 | 362 |
| 30 | Mechanism and biological significance of CD44 cleavage | Cancer Science | 2004 | 359 |
| 31 | Impact of Dual Lipid-Lowering Strategy With Ezetimibe and Atorvastatin on Coronary Plaque Regression in Patients With Percutaneous Coronary Intervention | Journal of the American College of Cardiology | 2015 | 352 |
| 32 | Minamata disease revisited: An update on the acute and chronic manifestations of methyl mercury poisoning | Journal of the Neurological Sciences | 2007 | 330 |
| 33 | International standardization of diagnostic criteria for vasospastic angina | European Heart Journal | 2017 | 325 |
| 34 | Human Microbiome Fusobacterium Nucleatum in Esophageal Cancer Tissue Is Associated with Prognosis | Clinical Cancer Research | 2016 | 322 |
| 35 | hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria | Cell Death and Differentiation | 2004 | 318 |
| 36 | Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells | Journal of Biological Chemistry | 2003 | 315 |
| 37 | Elevated Levels of VE-Cadherin-Positive Endothelial Microparticles in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease | Journal of the American College of Cardiology | 2005 | 306 |
| 38 | Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance | Cell Metabolism | 2009 | 302 |
| 39 | Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B | Atherosclerosis | 2012 | 299 |
| 40 | Sarcopenia is a Negative Prognostic Factor After Curative Resection of Colorectal Cancer | Annals of Surgical Oncology | 2015 | 290 |
| 41 | p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase | Kidney International | 2013 | 277 |
| 42 | Efficacy and Safety of Adjusted-Dose Prasugrel Compared With Clopidogrel in Japanese Patients With Acute Coronary Syndrome | Circulation Journal | 2014 | 277 |
| 43 | Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration | Nature Chemical Biology | 2012 | 274 |
| 44 | Molecular Physiology of Urate Transport | Physiology | 2005 | 261 |
| 45 | Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation | Journal of Cell Biology | 2004 | 260 |
| 46 | MicroRNA-21 Regulates the Proliferation and Invasion in Esophageal Squamous Cell Carcinoma | Clinical Cancer Research | 2009 | 254 |
| 47 | Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ | Cell Metabolism | 2006 | 249 |
| 48 | Protein S-guanylation by the biological signal 8-nitroguanosine 3′,5′-cyclic monophosphate | Nature Chemical Biology | 2007 | 249 |
| 49 | Dependence of Paclitaxel Sensitivity on a Functional Spindle Assembly Checkpoint | Cancer Research | 2004 | 248 |
| 50 | Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma | Cancer Discovery | 2018 | 248 |
