| # | Title | Journal | Year | Citations |
|---|
| 1 | Association of Sleep Duration with Mortality from Cardiovascular Disease and Other Causes for Japanese Men and Women: the JACC Study | Sleep | 2009 | 311 |
| 2 | Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression | Journal of Lipid Research | 2010 | 207 |
| 3 | Vitamin C: Basic Metabolism and Its Function as an Index of Oxidative Stress | Current Medicinal Chemistry | 2004 | 206 |
| 4 | Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women | Journal of Epidemiology and Community Health | 2011 | 186 |
| 5 | Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area | Journal of Epidemiology | 2016 | 180 |
| 6 | Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease | Alzheimer's Research and Therapy | 2014 | 148 |
| 7 | Recent Advances in the Study on Resveratrol | Biological and Pharmaceutical Bulletin | 2012 | 145 |
| 8 | Evaluation of oxidative stress during apoptosis and necrosis caused by carbon tetrachloride in rat liver | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2001 | 139 |
| 9 | Roles of PI3K/AKT/GSK3/mTOR Pathway in Cell Signaling of Mental Illnesses | Depression Research and Treatment | 2012 | 137 |
| 10 | Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species | FEBS Letters | 2002 | 129 |
| 11 | Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity | FEBS Letters | 2005 | 125 |
| 12 | Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality in a Japanese Cohort | JAMA Internal Medicine | 2019 | 120 |
| 13 | Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses | Diseases (Basel, Switzerland) | 2019 | 112 |
| 14 | Relationships of Age at Menarche and Menopause, and Reproductive Year with Mortality from Cardiovascular Disease in Japanese Postmenopausal Women: The JACC Study | Journal of Epidemiology | 2006 | 104 |
| 15 | Reproducibility and relative validity of dietary glycaemic index and load assessed with a self-administered diet-history questionnaire in Japanese adults | British Journal of Nutrition | 2008 | 100 |
| 16 | Interactions between Vitamin C and Vitamin E Are Observed in Tissues of Inherently Scorbutic Rats , | Journal of Nutrition | 1997 | 95 |
| 17 | Citral, a component of lemongrass oil, activates PPARα and γ and suppresses COX-2 expression | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 2010 | 93 |
| 18 | Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation | International Journal of Molecular Medicine | 2011 | 92 |
| 19 | Association of ceramides in human plasma with risk factors of atherosclerosis | Lipids | 2006 | 89 |
| 20 | Evaluation of oxidative stress during apoptosis and necrosis caused by d-galactosamine in rat liver | Biochemical Pharmacology | 2003 | 88 |
| 21 | Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study | Atherosclerosis | 2007 | 86 |
| 22 | NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease | Nature Communications | 2018 | 81 |
| 23 | Evaluation of oxidative stress based on lipid hydroperoxide, vitamin C and vitamin E during apoptosis and necrosis caused by thioacetamide in rat liver | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2000 | 75 |
| 24 | Involvement of hydrogen peroxide and hydroxyl radical in chemically induced apoptosis of HL-60 cells | Biochemical Pharmacology | 1999 | 72 |
| 25 | Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases | | 2014 | 72 |
| 26 | PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review) | International Journal of Molecular Medicine | 2017 | 72 |
| 27 | PI3K/AKT/PTEN pathway as a target for Crohn’s disease therapy (Review) | International Journal of Molecular Medicine | 2015 | 71 |
| 28 | Increased cathepsin K and tartrate-resistant acid phosphatase expression in bone of streptozotocin-induced diabetic rats | Bone | 2007 | 68 |
| 29 | The tumor suppressor PTEN interacts with p53 in hereditary cancer | International Journal of Oncology | 2014 | 68 |
| 30 | Change in tissue concentrations of lipid hydroperoxides, vitamin C and vitamin E in rats with streptozotocin-induced diabetes | Clinical Science | 1999 | 65 |
| 31 | Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease | Diseases (Basel, Switzerland) | 2018 | 65 |
| 32 | C-reactive protein levels and risk of mortality from cardiovascular disease in Japanese: The JACC Study | Atherosclerosis | 2009 | 63 |
| 33 | Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes | European Journal of Pharmacology | 2009 | 61 |
| 34 | In Vivo Antioxidative Activity of Propolis Evaluated by the Interaction with Vitamins C and E and the Level of Lipid Hydroperoxides in Rats | Journal of Agricultural and Food Chemistry | 2000 | 54 |
| 35 | Administration of zinc inhibits osteoclastogenesis through the suppression of RANK expression in bone | European Journal of Pharmacology | 2011 | 53 |
| 36 | Reactive Oxygen Species, Superoxide Dimutases, and PTEN-p53-AKT-MDM2 Signaling Loop Network in Mesenchymal Stem/Stromal Cells Regulation | Cells | 2018 | 53 |
| 37 | Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK | Bone | 2011 | 52 |
| 38 | Skipping breakfast adversely affects menstrual disorders in young college students | International Journal of Food Sciences and Nutrition | 2009 | 51 |
| 39 | Antimicrobial activity of Nutmeg against Escherichia coli O157 | Journal of Bioscience and Bioengineering | 2002 | 50 |
| 40 | Nitric oxide upregulates the cyclooxygenase-2 expression through the cAMP-response element in its promoter in several cancer cell lines | Oncogene | 2005 | 50 |
| 41 | Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study | Atherosclerosis | 2008 | 50 |
| 42 | Plasma Fatty Acid Composition, Estimated Desaturase Activities, and Intakes of Energy and Nutrient in Japanese Men with Abdominal Obesity or Metabolic Syndrome | Journal of Nutritional Science and Vitaminology | 2009 | 50 |
| 43 | Oxygenation of (3Z)-alkenal to (2E)-4-hydroxy-2-alkenal in soybean seed (Glycine max L.) | Lipids and Lipid Metabolism | 1996 | 47 |
| 44 | Influence of Cocoa Flavanols and Procyanidins on Free Radical-induced Human Erythrocyte Hemolysis | Clinical and Developmental Immunology | 2005 | 47 |
| 45 | Characterization of Psychrophilic Alanine Racemase fromBacillus psychrosaccharolyticus | Biochemical and Biophysical Research Communications | 1999 | 46 |
| 46 | Effect of Thermal Treatment on Radical-scavenging Activity of Some Spices | Food Science and Technology Research | 2006 | 46 |
| 47 | Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways | American Journal of Physiology - Endocrinology and Metabolism | 2011 | 46 |
| 48 | Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo | Nutrition and Metabolism | 2010 | 43 |
| 49 | Roles of PI3K/AKT/PTEN Pathway as a Target for Pharmaceutical Therapy | Open Medicinal Chemistry Journal | 2013 | 43 |
| 50 | Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects | Scientific Reports | 2016 | 42 |
