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Top Articles

#TitleJournalYearCitations
1Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4Science20131,223
2Functional Specialization of Interleukin-17 Family MembersImmunity20111,088
3Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicansImmunity2010648
4Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9Nature2015290
5Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic LigandsScience2013288
6Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain BarrierCell2012277
7Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral CortexCell2016276
8Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung InflammationImmunity2014263
9An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell NumbersImmunity2015240
10Schistosomamansonitriggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responsesProceedings of the National Academy of Sciences of the United States of America2010233
11Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the IntestineCell Host and Microbe2015215
12C-type Lectin MCL Is an FcRγ-Coupled Receptor that Mediates the Adjuvanticity of Mycobacterial Cord FactorImmunity2013209
13The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin InjuryImmunity2012208
14The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the AirwayImmunity2015199
15Differential pathways regulating innate and adaptive antitumor immune responses by particulate and soluble yeast-derived β-glucansBlood2011192
16Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 TraffickingImmunity2011180
17Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon CancerScience Translational Medicine2012177
18Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infectionProceedings of the National Academy of Sciences of the United States of America2013170
19IL-1 plays an important role in the bone metabolism under physiological conditionsInternational Immunology2010166
20Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathologyJournal of Experimental Medicine2011164
21Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria EquilibriumCell2019159
22Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussisJournal of Immunology2010158
23Dectin-1 diversifies Aspergillus fumigatus–specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiationJournal of Experimental Medicine2011146
24Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway HyperresponsivenessJournal of Immunology2012145
25A Tecpr1-Dependent Selective Autophagy Pathway Targets Bacterial PathogensCell Host and Microbe2011141
26IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis ModelsJournal of Investigative Dermatology2014137
27Platelet Activation Receptor CLEC-2 Regulates Blood/Lymphatic Vessel Separation by Inhibiting Proliferation, Migration, and Tube Formation of Lymphatic Endothelial CellsJournal of Biological Chemistry2012136
28Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing Treg cells through modification of the intestinal microbiotaNature Immunology2018134
29IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in MicePLoS ONE2011128
30IL-9 Promotes Th17 Cell Migration into the Central Nervous System via CC Chemokine Ligand-20 Produced by AstrocytesJournal of Immunology2011124
31The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophagesNature Communications2016117
32Periprosthetic osteolysis: Characterizing the innate immune response to titanium wear‐particlesJournal of Orthopaedic Research2010110
33Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 ComplexDiabetes2012108
34Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated PhenotypePLoS ONE2011107
35Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephalyMolecular and Cellular Neurosciences2011105
36IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ ReleasePLoS ONE2016105
37IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cellsNature Communications2015102
38Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by down-regulating Th1 and Th17Blood201297
39Guanosine and its modified derivatives are endogenous ligands for TLR7International Immunology201697
40Excess IL-1 Signaling Enhances the Development of Th17 Cells by Downregulating TGF-β–Induced Foxp3 ExpressionJournal of Immunology201496
41GATA-1 regulates the generation and function of basophilsProceedings of the National Academy of Sciences of the United States of America201394
42Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine AsthmaJournal of Immunology201293
43Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor–TRAF6 signalingJournal of Experimental Medicine201593
44Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In VivoCell Metabolism202093
45Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesiaMolecular and Cellular Neurosciences201392
46B7-H6/NKp30 interaction: a mechanism of alerting NK cells against tumorsCellular and Molecular Life Sciences201191
47IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB ActivationClinical Cancer Research201690
48C-Type Lectin Receptors Differentially Induce Th17 Cells and Vaccine Immunity to the Endemic Mycosis of North AmericaJournal of Immunology201488
49Interdependence between Interleukin-1 and Tumor Necrosis Factor Regulates TNF-Dependent Control of Mycobacterium tuberculosis InfectionImmunity201587
50Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviourEMBO Journal200986