| # | Title | Journal | Year | Citations |
|---|
| 1 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 2 | Finding the missing heritability of complex diseases | Nature | 2009 | 7,490 |
| 3 | Membrane lipids: where they are and how they behave | Nature Reviews Molecular Cell Biology | 2008 | 5,565 |
| 4 | Human Genetics Shape the Gut Microbiome | Cell | 2014 | 2,523 |
| 5 | Evolution of genes and genomes on the Drosophila phylogeny | Nature | 2007 | 1,886 |
| 6 | Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters | Science | 2008 | 1,758 |
| 7 | Diversity and heritability of the maize rhizosphere microbiome under field conditions | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,594 |
| 8 | RepeatModeler2 for automated genomic discovery of transposable element families | Proceedings of the National Academy of Sciences of the United States of America | 2020 | 1,480 |
| 9 | ERM proteins and merlin: integrators at the cell cortex | Nature Reviews Molecular Cell Biology | 2002 | 1,468 |
| 10 | Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome | Nature | 2015 | 1,457 |
| 11 | Improved Bacterial 16S rRNA Gene (V4 and V4-5) and Fungal Internal Transcribed Spacer Marker Gene Primers for Microbial Community Surveys | MSystems | 2016 | 1,364 |
| 12 | Evolutionary and Biomedical Insights from the Rhesus Macaque Genome | Science | 2007 | 1,283 |
| 13 | Universally Sloppy Parameter Sensitivities in Systems Biology Models | PLoS Computational Biology | 2007 | 1,026 |
| 14 | Organizing the cell cortex: the role of ERM proteins | Nature Reviews Molecular Cell Biology | 2010 | 884 |
| 15 | Genetic Determinants of the Gut Microbiome in UK Twins | Cell Host and Microbe | 2016 | 831 |
| 16 | Ten things you should know about transposable elements | Genome Biology | 2018 | 817 |
| 17 | Evolutionary changes in cis and trans gene regulation | Nature | 2004 | 771 |
| 18 | Interactions of Mitochondrial and Nuclear Genes That Affect Male Gametophyte Development | Plant Cell | 2004 | 742 |
| 19 | The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets | Molecular Cell | 2010 | 738 |
| 20 | Insect Seminal Fluid Proteins: Identification and Function | Annual Review of Entomology | 2011 | 734 |
| 21 | Natural selection on protein-coding genes in the human genome | Nature | 2005 | 718 |
| 22 | Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal | Genes and Development | 2005 | 705 |
| 23 | Getting up to speed with transcription elongation by RNA polymerase II | Nature Reviews Molecular Cell Biology | 2015 | 692 |
| 24 | Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing | Science | 2013 | 683 |
| 25 | Proton pump inhibitors alter the composition of the gut microbiota | Gut | 2016 | 682 |
| 26 | Role of Formins in Actin Assembly: Nucleation and Barbed-End Association | Science | 2002 | 664 |
| 27 | Microbiota and Host Nutrition across Plant and Animal Kingdoms | Cell Host and Microbe | 2015 | 628 |
| 28 | Conducting a Microbiome Study | Cell | 2014 | 625 |
| 29 | Host genetic variation impacts microbiome composition across human body sites | Genome Biology | 2015 | 612 |
| 30 | Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome | PLoS Genetics | 2008 | 586 |
| 31 | The 4D nucleome project | Nature | 2017 | 579 |
| 32 | Prolyl cis-trans isomerization as a molecular timer | Nature Chemical Biology | 2007 | 574 |
| 33 | p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans | PLoS Genetics | 2006 | 573 |
| 34 | Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures | Nature | 2007 | 573 |
| 35 | Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers | Nature Genetics | 2014 | 572 |
| 36 | Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain | Cell | 2000 | 555 |
| 37 | Selection on soil microbiomes reveals reproducible impacts on plant function | ISME Journal | 2015 | 549 |
| 38 | Recent Explosive Human Population Growth Has Resulted in an Excess of Rare Genetic Variants | Science | 2012 | 489 |
| 39 | NAD+-Dependent Modulation of Chromatin Structure and Transcription by Nucleosome Binding Properties of PARP-1 | Cell | 2004 | 487 |
| 40 | Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons | ELife | 2014 | 484 |
| 41 | Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism | Cell Metabolism | 2015 | 481 |
| 42 | Genomic features of bacterial adaptation to plants | Nature Genetics | 2018 | 480 |
| 43 | PARP Goes Transcription | Cell | 2003 | 478 |
| 44 | Defining mechanisms that regulate RNA polymerase II transcription in vivo | Nature | 2009 | 476 |
| 45 | Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin | Neuron | 2010 | 465 |
| 46 | ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology | Developmental Cell | 2012 | 465 |
| 47 | A systematic RNAi screen for longevity genes in C. elegans | Genes and Development | 2005 | 464 |
| 48 | The stoichiometry of Gag protein in HIV-1 | Nature Structural and Molecular Biology | 2004 | 462 |
| 49 | m6A enhances the phase separation potential of mRNA | Nature | 2019 | 460 |
| 50 | A Rapid, Extensive, and Transient Transcriptional Response to Estrogen Signaling in Breast Cancer Cells | Cell | 2011 | 458 |
