| # | Title | Journal | Year | Citations |
|---|
| 1 | Involvement of linear polyubiquitylation of NEMO in NF-κB activation | Nature Cell Biology | 2009 | 870 |
| 2 | Directed differentiation of telencephalic precursors from embryonic stem cells | Nature Neuroscience | 2005 | 727 |
| 3 | A ubiquitin ligase complex assembles linear polyubiquitin chains | EMBO Journal | 2006 | 663 |
| 4 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness | Cell Stem Cell | 2013 | 652 |
| 5 | Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis | The Lancet Gastroenterology and Hepatology | 2019 | 616 |
| 6 | Effects of Oral Branched-Chain Amino Acid Granules on Event-Free Survival in Patients With Liver Cirrhosis | Clinical Gastroenterology and Hepatology | 2005 | 467 |
| 7 | A histone H3 methyltransferase controls epigenetic events required for meiotic prophase | Nature | 2005 | 444 |
| 8 | Diagnostic Accuracy of 11C-Methionine PET for Differentiation of Recurrent Brain Tumors from Radiation Necrosis After Radiotherapy | Journal of Nuclear Medicine | 2008 | 379 |
| 9 | E3 ubiquitin ligase that recognizes sugar chains | Nature | 2002 | 341 |
| 10 | Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan | Blood | 2010 | 303 |
| 11 | Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population | BMC Gastroenterology | 2012 | 295 |
| 12 | Discontinuation of dasatinib in patients with chronic myeloid leukaemia who have maintained deep molecular response for longer than 1 year (DADI trial): a multicentre phase 2 trial | Lancet Haematology,the | 2015 | 261 |
| 13 | Expression of the Activating Transcription Factor 3 Prevents c-Jun N-Terminal Kinase-Induced Neuronal Death by Promoting Heat Shock Protein 27 Expression and Akt Activation | Journal of Neuroscience | 2003 | 241 |
| 14 | Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells | Nature Cell Biology | 2008 | 230 |
| 15 | Mitochondria-related male infertility | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 218 |
| 16 | Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508 | Molecular Biology of the Cell | 2008 | 212 |
| 17 | MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis | Gut | 2012 | 212 |
| 18 | Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone | Cancer | 2005 | 210 |
| 19 | Mechanism of recipient cell-dependent differences in exosome uptake | BMC Cancer | 2018 | 200 |
| 20 | Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form | Neuroscience Letters | 2003 | 199 |
| 21 | Hepatocyte Growth Factor Expression in EGFR Mutant Lung Cancer with Intrinsic and Acquired Resistance to Tyrosine Kinase Inhibitors in a Japanese Cohort | Journal of Thoracic Oncology | 2011 | 196 |
| 22 | A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease | Journal of Gastroenterology | 2011 | 185 |
| 23 | Oxidative Stress in Leukocytes Is a Possible Link Between Blood Pressure, Blood Glucose, and C-Reacting Protein | Hypertension | 2002 | 183 |
| 24 | A Multi-institutional Prospective Observational Study of Stereotactic Radiosurgery for Patients With Multiple Brain Metastases (JLGK0901 Study Update): Irradiation-related Complications and Long-term Maintenance of Mini-Mental State Examination Scores | International Journal of Radiation Oncology Biology Physics | 2017 | 183 |
| 25 | Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans | Diabetes | 2008 | 177 |
| 26 | Identification of the ubiquitin–protein ligase that recognizes oxidized IRP2 | Nature Cell Biology | 2003 | 176 |
| 27 | Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype | International Journal of Obesity | 2015 | 172 |
| 28 | Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer | Gastroenterology | 2016 | 171 |
| 29 | Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 170 |
| 30 | Incidence and Management of Bile Leakage After Hepatic Resection for Malignant Hepatic Tumors | Journal of the American College of Surgeons | 2002 | 162 |
| 31 | A new Classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy | Journal of Diabetes Investigation | 2015 | 157 |
| 32 | Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice | Journal of Nutritional Biochemistry | 2017 | 155 |
| 33 | Suppression of hepatic stellate cell activation by microRNA-29b | Biochemical and Biophysical Research Communications | 2011 | 152 |
| 34 | Fibrotic disorders in the eye: Targets of gene therapy | Progress in Retinal and Eye Research | 2008 | 151 |
| 35 | Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality | Molecular and Cellular Biology | 2005 | 149 |
| 36 | Comprehensive miRNA Expression Analysis in Peripheral Blood Can Diagnose Liver Disease | PLoS ONE | 2012 | 149 |
| 37 | Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients | Clinical and Experimental Allergy | 2003 | 147 |
| 38 | Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains | Genes To Cells | 2004 | 147 |
| 39 | Erythrophagocytosis by Liver Macrophages (Kupffer Cells) Promotes Oxidative Stress, Inflammation, and Fibrosis in a Rabbit Model of Steatohepatitis | American Journal of Pathology | 2007 | 140 |
| 40 | Trophic Effect of Multiple Growth Factors in Amniotic Fluid or Human Milk on Cultured Human Fetal Small Intestinal Cells | Journal of Pediatric Gastroenterology and Nutrition | 2002 | 139 |
| 41 | Development of pharyngeal arch arteries in early mouse embryo | Journal of Anatomy | 2002 | 137 |
| 42 | Involvement of Heme Regulatory Motif in Heme-Mediated Ubiquitination and Degradation of IRP2 | Molecular Cell | 2005 | 135 |
| 43 | Prospective study of reactivation of hepatitis B virus in patients with rheumatoid arthritis who received immunosuppressive therapy: evaluation of both HBsAg-positive and HBsAg-negative cohorts | Journal of Gastroenterology | 2011 | 135 |
| 44 | Serum Phosphate and Calcium Should Be Primarily and Consistently Controlled in Prevalent Hemodialysis Patients | Therapeutic Apheresis and Dialysis | 2013 | 133 |
| 45 | Role of the Gut–Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship | Hepatology Communications | 2019 | 131 |
| 46 | Stimulation of Proliferation of Rat Hepatic Stellate Cells by Galectin-1 and Galectin-3 through Different Intracellular Signaling Pathways | Journal of Biological Chemistry | 2003 | 130 |
| 47 | Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats | Gut | 2007 | 129 |
| 48 | Possible effects of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease | American Journal of Medicine | 2003 | 128 |
| 49 | Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis | Laboratory Investigation | 2004 | 123 |
| 50 | Inflammation and fibrogenesis in steatohepatitis | Journal of Gastroenterology | 2012 | 123 |
