| # | Title | Journal | Year | Citations |
|---|
| 1 | Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons | Cell | 2012 | 3,152 |
| 2 | 5′ UTR m6A Promotes Cap-Independent Translation | Cell | 2015 | 1,414 |
| 3 | Reading, writing and erasing mRNA methylation | Nature Reviews Molecular Cell Biology | 2019 | 1,403 |
| 4 | m6A RNA methylation promotes XIST-mediated transcriptional repression | Nature | 2016 | 1,250 |
| 5 | Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior | Science | 2006 | 1,201 |
| 6 | Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome | Nature Methods | 2015 | 1,157 |
| 7 | RNA Mimics of Green Fluorescent Protein | Science | 2011 | 1,091 |
| 8 | Dynamic m6A mRNA methylation directs translational control of heat shock response | Nature | 2015 | 990 |
| 9 | Crystal Structure of the PTEN Tumor Suppressor | Cell | 1999 | 974 |
| 10 | The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells | Nature Medicine | 2017 | 971 |
| 11 | Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival | Cell | 2007 | 855 |
| 12 | Rethinking m6A Readers, Writers, and Erasers | Annual Review of Cell and Developmental Biology | 2017 | 833 |
| 13 | The dynamic epitranscriptome: N6-methyladenosine and gene expression control | Nature Reviews Molecular Cell Biology | 2014 | 812 |
| 14 | Reversible methylation of m6Am in the 5′ cap controls mRNA stability | Nature | 2017 | 797 |
| 15 | Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt | Developmental Cell | 2008 | 701 |
| 16 | The Biochemistry of Sirtuins | Annual Review of Biochemistry | 2006 | 656 |
| 17 | BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure | Science | 2002 | 645 |
| 18 | Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells | Current Biology | 1997 | 630 |
| 19 | Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 625 |
| 20 | Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation | Journal of Biological Chemistry | 1995 | 546 |
| 21 | Clinical Pharmacology of Opioids for Pain | Clinical Journal of Pain | 2002 | 498 |
| 22 | The Dbl family of oncogenes | Current Opinion in Cell Biology | 1996 | 497 |
| 23 | Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling | Nature Biotechnology | 2010 | 460 |
| 24 | m6A enhances the phase separation potential of mRNA | Nature | 2019 | 460 |
| 25 | Fluorescence Imaging of Cellular Metabolites with RNA | Science | 2012 | 451 |
| 26 | A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA | Cell | 2020 | 448 |
| 27 | Reading m6A in the Transcriptome: m6A-Binding Proteins | Trends in Cell Biology | 2018 | 445 |
| 28 | Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product | Nature | 1991 | 437 |
| 29 | Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation | Cell Metabolism | 2009 | 422 |
| 30 | The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry | Nature Neuroscience | 2013 | 414 |
| 31 | Local translation of RhoA regulates growth cone collapse | Nature | 2005 | 407 |
| 32 | Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons | Journal of Alzheimer's Disease | 2010 | 404 |
| 33 | Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity | Nature | 2014 | 387 |
| 34 | Identification of a Mouse p21Cdc42/Rac Activated Kinase | Journal of Biological Chemistry | 1995 | 383 |
| 35 | The “Soluble” Adenylyl Cyclase in Sperm Mediates Multiple Signaling Events Required for Fertilization | Developmental Cell | 2005 | 353 |
| 36 | Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. | Journal of Biological Chemistry | 1994 | 352 |
| 37 | SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 334 |
| 38 | A superfolding Spinach2 reveals the dynamic nature of trinucleotide repeat–containing RNA | Nature Methods | 2013 | 317 |
| 39 | Kinetic Properties of “Soluble” Adenylyl Cyclase | Journal of Biological Chemistry | 2003 | 316 |
| 40 | The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112 | Nucleic Acids Research | 2019 | 312 |
| 41 | Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85 | Journal of Biological Chemistry | 1994 | 311 |
| 42 | Fragile X mice develop sensory hyperreactivity to auditory stimuli | Neuroscience | 2001 | 305 |
| 43 | Structural basis for activity of highly efficient RNA mimics of green fluorescent protein | Nature Structural and Molecular Biology | 2014 | 299 |
| 44 | Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents | AAPS Journal | 2006 | 298 |
| 45 | Transcriptional Activation of the Human p21 Gene by Retinoic Acid Receptor | Journal of Biological Chemistry | 1996 | 277 |
| 46 | NAD+and Vitamin B3: From Metabolism to Therapies | Journal of Pharmacology and Experimental Therapeutics | 2008 | 273 |
| 47 | Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome | Science | 2014 | 266 |
| 48 | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1 | Nature Communications | 2018 | 261 |
| 49 | Functional expression of a rapidly inactivating neuronal calcium channel | Nature | 1993 | 257 |
| 50 | Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival | Nature Cell Biology | 2008 | 257 |
