| # | Title | Journal | Year | Citations |
|---|
| 1 | Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis | Nature | 2017 | 767 |
| 2 | Heparin prevents antiphospholipid antibody–induced fetal loss by inhibiting complement activation | Nature Medicine | 2004 | 620 |
| 3 | Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer | Clinical Cancer Research | 2007 | 608 |
| 4 | Complement C3 Activation Is Required for Antiphospholipid Antibody-induced Fetal Loss | Journal of Experimental Medicine | 2002 | 557 |
| 5 | Phase II Multicenter Study of Abiraterone Acetate Plus Prednisone Therapy in Patients With Docetaxel-Treated Castration-Resistant Prostate Cancer | Journal of Clinical Oncology | 2010 | 396 |
| 6 | Hepatitis C virus infection in USA: an estimate of true prevalence | Liver International | 2011 | 355 |
| 7 | Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo | Nature Medicine | 2003 | 352 |
| 8 | Circulating Tumor Cell Analysis in Patients with Progressive Castration-Resistant Prostate Cancer | Clinical Cancer Research | 2007 | 329 |
| 9 | Assessing illness severity: Does clinical judgment work? | Journal of Chronic Diseases | 1986 | 295 |
| 10 | Role of STAT3 in Type I Interferon Responses | Journal of Biological Chemistry | 2006 | 280 |
| 11 | Antibiotics as Part of the Management of Severe Acute Malnutrition | New England Journal of Medicine | 2013 | 279 |
| 12 | Androgens and male physiology the syndrome of 5α-reductase-2 deficiency | Molecular and Cellular Endocrinology | 2002 | 274 |
| 13 | Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome | Journal of Clinical Investigation | 2003 | 266 |
| 14 | A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo | Cancer Cell | 2010 | 263 |
| 15 | Modulation of NF-κB Activity and Apoptosis in Chronic Lymphocytic Leukemia B Cells | Journal of Immunology | 2000 | 258 |
| 16 | Small-Cell Carcinomas of the Gastrointestinal Tract: A Review | Journal of Clinical Oncology | 2004 | 256 |
| 17 | The MinK-related peptides | Neuropharmacology | 2004 | 241 |
| 18 | PCR-Based Method To Differentiate the Subspecies of the Mycobacterium tuberculosis Complex on the Basis of Genomic Deletions | Journal of Clinical Microbiology | 2003 | 237 |
| 19 | The Semiconserved Head Structure of Plasmodium falciparum Erythrocyte Membrane Protein 1 Mediates Binding to Multiple Independent Host Receptors | Journal of Experimental Medicine | 2000 | 223 |
| 20 | Targeting skeletal endothelium to ameliorate bone loss | Nature Medicine | 2018 | 218 |
| 21 | Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 217 |
| 22 | Differential Modulation of Stimulatory and Inhibitory Fcγ Receptors on Human Monocytes by Th1 and Th2 Cytokines | Journal of Immunology | 2001 | 215 |
| 23 | The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms | Immunological Reviews | 2018 | 211 |
| 24 | EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis | Cancer Cell | 2016 | 200 |
| 25 | Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial | Lancet Respiratory Medicine,the | 2017 | 200 |
| 26 | Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+CD28– cytotoxic effector clones | International Immunology | 1999 | 196 |
| 27 | Sensitization of IFN-γ Jak-STAT signaling during macrophage activation | Nature Immunology | 2002 | 194 |
| 28 | Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial | PLoS Medicine | 2017 | 194 |
| 29 | A Subset of Liver NK T Cells Is Activated during Leishmania donovani Infection by CD1d-bound Lipophosphoglycan | Journal of Experimental Medicine | 2004 | 191 |
| 30 | Sphingolipid Signaling in Metabolic Disorders | Cell Metabolism | 2012 | 190 |
| 31 | Fluorescence In situ Hybridization Analysis of Circulating Tumor Cells in Metastatic Prostate Cancer | Clinical Cancer Research | 2009 | 185 |
| 32 | Single‐cell quantification of IL‐2 response by effector and regulatory T cells reveals critical plasticity in immune response | Molecular Systems Biology | 2010 | 181 |
| 33 | Novel Genetic Polymorphisms That Further Delineate the Phylogeny of the Mycobacterium tuberculosis Complex | Journal of Bacteriology | 2006 | 176 |
| 34 | A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction | Cell | 2000 | 173 |
| 35 | TET1 is a tumor suppressor of hematopoietic malignancy | Nature Immunology | 2015 | 173 |
| 36 | Survival of leukemic B cells promoted by engagement of the antigen receptor | Blood | 2001 | 170 |
| 37 | The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation | Nature | 2014 | 168 |
| 38 | Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study | Lancet Respiratory Medicine,the | 2019 | 168 |
| 39 | Patterns and Intensity of Medical Therapy in Patients Undergoing Percutaneous Coronary Intervention | JAMA - Journal of the American Medical Association | 2011 | 165 |
| 40 | Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies | American Journal of Obstetrics and Gynecology | 2007 | 163 |
| 41 | Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma | Blood | 2004 | 159 |
| 42 | Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 156 |
| 43 | Morbidity during hospitalization: Can we predict it? | Journal of Chronic Diseases | 1987 | 154 |
| 44 | The transcription factor XBP1 is selectively required for eosinophil differentiation | Nature Immunology | 2015 | 154 |
| 45 | POST-CHEMOTHERAPY SURGERY IN PATIENTS WITH UNRESECTABLE OR REGIONALLY METASTATIC BLADDER CANCER | Journal of Urology | 2001 | 141 |
| 46 | Novel Antibiotic Combinations against Infections with Almost Completely Resistant Pseudomonas aeruginosa and Acinetobacter Species | Clinical Infectious Diseases | 2006 | 136 |
| 47 | Reprogramming of IL-10 Activity and Signaling by IFN-γ | Journal of Immunology | 2003 | 134 |
| 48 | EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop | Nature Communications | 2017 | 132 |
| 49 | Prognostic factors for survival of patients with advanced urothelial tumors treated with methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy | Cancer | 1991 | 131 |
| 50 | Identifying Vulnerable Older Adults with Cancer: Integrating Geriatric Assessment into Oncology Practice | Journal of the American Geriatrics Society | 2007 | 131 |
