| # | Title | Journal | Year | Citations |
|---|
| 1 | Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome | Nature | 2003 | 1,925 |
| 2 | Cellular Senescence in Aging Primates | Science | 2006 | 910 |
| 3 | Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP | Nature | 1999 | 808 |
| 4 | Bypass of Senescence After Disruption of p21CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts | Science | 1997 | 767 |
| 5 | Initiation of Mammalian Liver Development from Endoderm by Fibroblast Growth Factors | Science | 1999 | 660 |
| 6 | Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm | Genes and Development | 2001 | 573 |
| 7 | A bipotential precursor population for pancreas and liver within the embryonic endoderm | Development (Cambridge) | 2001 | 523 |
| 8 | Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control. | Genes and Development | 1996 | 515 |
| 9 | Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation | Molecular and Cellular Biology | 2001 | 368 |
| 10 | Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein | Molecular and Cellular Biology | 2000 | 357 |
| 11 | Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome | EMBO Journal | 1998 | 339 |
| 12 | Molecular Biology, Epidemiology, and Pathogenesis of Progressive Multifocal Leukoencephalopathy, the JC Virus-Induced Demyelinating Disease of the Human Brain | Clinical Microbiology Reviews | 2012 | 337 |
| 13 | Penetration of the Stigma and Style Elicits a Novel Transcriptome in Pollen Tubes, Pointing to Genes Critical for Growth in a Pistil | PLoS Genetics | 2009 | 319 |
| 14 | c-Myc Regulates Cyclin D-Cdk4 and -Cdk6 Activity but Affects Cell Cycle Progression at Multiple Independent Points | Molecular and Cellular Biology | 1999 | 296 |
| 15 | Genetic and Chemical Reductions in Protein Phosphatase Activity Alter Auxin Transport, Gravity Response, and Lateral Root Growth | Plant Cell | 2001 | 264 |
| 16 | An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila | PLoS Genetics | 2013 | 239 |
| 17 | Transcriptional landscape of repetitive elements in normal and cancer human cells | BMC Genomics | 2014 | 233 |
| 18 | Fertilization Mechanisms in Flowering Plants | Current Biology | 2016 | 229 |
| 19 | Role of p14 ARF in Replicative and Induced Senescence of Human Fibroblasts | Molecular and Cellular Biology | 2001 | 220 |
| 20 | An Early Developmental Transcription Factor Complex that Is More Stable on Nucleosome Core Particles Than on Free DNA | Molecular Cell | 1999 | 219 |
| 21 | Evidence for DNA-PK-Dependent and -Independent DNA Double-Strand Break Repair Pathways in Mammalian Cells as a Function of the Cell Cycle | Molecular and Cellular Biology | 1997 | 217 |
| 22 | A Xenopus Protein Related to hnRNP I Has a Role in Cytoplasmic RNA Localization | Molecular Cell | 1999 | 216 |
| 23 | A Sequential Two-Step Mechanism for the Production of the Mature p17:p12 Form of Caspase-3 in Vitro | Journal of Biological Chemistry | 1997 | 211 |
| 24 | Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with Camptothecin | Journal of Biological Chemistry | 2002 | 206 |
| 25 | RKIP Sensitizes Prostate and Breast Cancer Cells to Drug-induced Apoptosis | Journal of Biological Chemistry | 2004 | 203 |
| 26 | Developmental Competence of the Gut Endoderm: Genetic Potentiation by GATA and HNF3/Fork Head Proteins | Developmental Biology | 1999 | 202 |
| 27 | The number of p16INK4a positive cells in human skin reflects biological age | Aging Cell | 2012 | 200 |
| 28 | A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns | Journal of Biological Chemistry | 2003 | 194 |
| 29 | Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice | Cell Metabolism | 2011 | 193 |
| 30 | Disruption of a Guard Cell–Expressed Protein Phosphatase 2A Regulatory Subunit, RCN1, Confers Abscisic Acid Insensitivity in Arabidopsis | Plant Cell | 2002 | 192 |
| 31 | Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis | Cell Metabolism | 2019 | 192 |
| 32 | p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress | Molecular Biology of the Cell | 2004 | 183 |
| 33 | Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination | Cell Growth & Differentiation: the Molecular Biology Journal of the American Association for Cancer Research | 1997 | 183 |
| 34 | Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation | Science | 2018 | 180 |
| 35 | A bipotential precursor population for pancreas and liver within the embryonic endoderm | Development (Cambridge) | 2001 | 179 |
| 36 | A Fruitful Journey: Pollen Tube Navigation from Germination to Fertilization | Annual Review of Plant Biology | 2019 | 176 |
| 37 | Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 175 |
| 38 | GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein–protein interactions | Blood Cells, Molecules, and Diseases | 2004 | 174 |
| 39 | Ku86 is essential in human somatic cells | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 172 |
| 40 | Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila | Proceedings of the National Academy of Sciences of the United States of America | 2016 | 169 |
| 41 | Dynamic response of RNA editing to temperature in Drosophila | BMC Biology | 2015 | 168 |
| 42 | Genome-wide siRNA screen identifies the retromer as a cellular entry factor for human papillomavirus | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 165 |
| 43 | Loss of Raf Kinase Inhibitor Protein Promotes Cell Proliferation and Migration of Human Hepatoma Cells | Gastroenterology | 2006 | 163 |
| 44 | Pollen Tubes Lacking a Pair of K+ Transporters Fail to Target Ovules inArabidopsis | Plant Cell | 2011 | 148 |
| 45 | Localization of RNAs to the Mitochondrial Cloud in Xenopus Oocytes through Entrapment and Association with Endoplasmic Reticulum | Molecular Biology of the Cell | 2004 | 145 |
| 46 | PIWI proteins and PIWI-interacting RNAs function in Hydra somatic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 140 |
| 47 | The prion hypothesis: from biological anomaly to basic regulatory mechanism | Nature Reviews Molecular Cell Biology | 2010 | 137 |
| 48 | Protein Phosphatase 2A Controls Ethylene Biosynthesis by Differentially Regulating the Turnover of ACC Synthase Isoforms | PLoS Genetics | 2011 | 134 |
| 49 | Age‐associated increase in heterochromatic marks in murine and primate tissues | Aging Cell | 2011 | 131 |
| 50 | Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria | Molecular and Cellular Biology | 2001 | 126 |
