| # | Title | Journal | Year | Citations |
|---|
| 1 | ESPEN Guidelines on Enteral Nutrition: Intensive care | Clinical Nutrition | 2006 | 1,241 |
| 2 | Systematic review of enhanced recovery programmes in colonic surgery | British Journal of Surgery | 2006 | 624 |
| 3 | Bile acid receptors as targets for drug development | Nature Reviews Gastroenterology and Hepatology | 2014 | 565 |
| 4 | Hypoxia, Hypoxia-Inducible Transcription Factor, and Macrophages in Human Atherosclerotic Plaques Are Correlated With Intraplaque Angiogenesis | Journal of the American College of Cardiology | 2008 | 395 |
| 5 | Evidence for endocytosis of E-selectin in human endothelial cells | European Journal of Immunology | 1992 | 375 |
| 6 | E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro | Immunology | 1992 | 375 |
| 7 | Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase | Journal of Biological Chemistry | 1996 | 363 |
| 8 | Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension | Gastroenterology | 2004 | 252 |
| 9 | Tryptophan depletion in normal volunteers produces selective impairment in memory consolidation | Psychopharmacology | 1999 | 248 |
| 10 | Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages. | Journal of Immunology | 1993 | 243 |
| 11 | Rapid routine determination of amino acids in plasma by high-performance liquid chromatography with a 2–3 μm Spherisorb ODS II column | Biomedical Applications | 1993 | 237 |
| 12 | The ascending pathophysiology of cholestatic liver disease | Hepatology | 2017 | 236 |
| 13 | Differential regulatory effects of adenosine on cytokine release by activated human monocytes. | Journal of Immunology | 1994 | 227 |
| 14 | Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages | Journal of Immunology | 1993 | 226 |
| 15 | Renal metabolism of amino acids: its role in interorgan amino acid exchange | American Journal of Clinical Nutrition | 2004 | 205 |
| 16 | Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression | PLoS Genetics | 2012 | 194 |
| 17 | Monoclonal antibody to TN F in severe septic shock | Lancet, The | 1990 | 192 |
| 18 | Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow | Journal of Hepatology | 2004 | 189 |
| 19 | Differential regulatory effects of adenosine on cytokine release by activated human monocytes | Journal of Immunology | 1994 | 189 |
| 20 | Beyond diversity: functional microbiomics of the human colon | Trends in Microbiology | 2006 | 187 |
| 21 | Interorgan ammonia and amino acid metabolism in metabolically stable patients with cirrhosis and a TIPSS | Hepatology | 2002 | 183 |
| 22 | Review of 404 Patients with Gastrointestinal Fistulas Impact of Parenteral Nutrition | Annals of Surgery | 1979 | 181 |
| 23 | Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells | American Journal of Physiology - Cell Physiology | 1996 | 181 |
| 24 | Cytokines tumor necrosis factor and interleukin-6 in experimental biliary obstruction in mice | Hepatology | 1992 | 179 |
| 25 | Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria | European Journal of Immunology | 1997 | 166 |
| 26 | Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study | PLoS ONE | 2017 | 163 |
| 27 | An implanted neuromuscular stimulator for fecal continence following previously implanted gracilis muscle | Diseases of the Colon and Rectum | 1988 | 149 |
| 28 | Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration | Cancer | 2005 | 145 |
| 29 | Interorgan ammonia metabolism in liver failure | Neurochemistry International | 2002 | 136 |
| 30 | Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors. | Journal of Immunology | 1997 | 135 |
| 31 | Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation | American Journal of Physiology - Endocrinology and Metabolism | 2012 | 132 |
| 32 | Intestinal and hepatic metabolism of glutamine and citrulline in humans | Journal of Physiology | 2007 | 129 |
| 33 | The evolutionary benefit of insulin resistance | Clinical Nutrition | 2012 | 128 |
| 34 | Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA | Free Radical Biology and Medicine | 1998 | 127 |
| 35 | Genetic and epigenetic regulation of gene expression in fetal and adult human livers | BMC Genomics | 2014 | 124 |
| 36 | Lipopolysaccharide Toxicity-Regulating Proteins in Bacteremia | Journal of Infectious Diseases | 1995 | 123 |
| 37 | Adenosine inhibits neutrophil degranulation in activated human whole blood: involvement of adenosine A2 and A3 receptors | Journal of Immunology | 1997 | 120 |
| 38 | Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells | Journal of Immunology | 1998 | 118 |
| 39 | Influence of nephrectomy on tumor necrosis factor clearance in a murine model. | Journal of Immunology | 1993 | 118 |
| 40 | Gut Permeability, Intestinal Morphology, and Nutritional Depletion | Nutrition | 1998 | 114 |
| 41 | Slow release of soluble TNF receptors by monocytes in vitro. | Journal of Immunology | 1994 | 114 |
| 42 | Plasma citrulline concentration: A surrogate end point for radiation-induced mucosal atrophy of the small bowel. A feasibility study in 23 patients | International Journal of Radiation Oncology Biology Physics | 2004 | 113 |
| 43 | EVIDENCE FOR INTESTINAL AND LIVER EPITHELIAL CELL INJURY IN THE EARLY PHASE OF SEPSIS | Shock | 2007 | 113 |
| 44 | Lymphokine dependence of in vivo expression of MHC class II antigens by endothelium | Nature | 1985 | 112 |
| 45 | Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia | Hepatology | 2001 | 112 |
| 46 | Suppression of cellular immunity in obstructive jaundice is caused by endotoxins: A study with germ-free rats | Gastroenterology | 1990 | 110 |
| 47 | The kidney plays a major role in the hyperammonemia seen after simulated or actual GI bleeding in patients with cirrhosis | Hepatology | 2003 | 108 |
| 48 | Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions. Functional activation of Fc gamma RII by treatment with proteases or neuraminidase | Journal of Immunology | 1990 | 108 |
| 49 | Influence of nephrectomy on tumor necrosis factor clearance in a murine model | Journal of Immunology | 1993 | 107 |
| 50 | Cross-linking of both Fc gamma RI and Fc gamma RII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-Fc gamma R interactions. Functional activation of Fc gamma RII by treatment with proteases or neuraminidase. | Journal of Immunology | 1990 | 107 |
