| # | Title | Journal | Year | Citations |
|---|
| 1 | Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers | Nature Medicine | 2020 | 736 |
| 2 | The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5 | Journal of Clinical Investigation | 2010 | 675 |
| 3 | MEXPRESS update 2019 | Nucleic Acids Research | 2019 | 179 |
| 4 | Low skeletal muscle radiation attenuation and visceral adiposity are associated with overall survival and surgical site infections in patients with pancreatic cancer | Journal of Cachexia, Sarcopenia and Muscle | 2017 | 176 |
| 5 | Loss of skeletal muscle during neoadjuvant chemotherapy is related to decreased survival in ovarian cancer patients | Journal of Cachexia, Sarcopenia and Muscle | 2016 | 161 |
| 6 | Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies | Thyroid | 2016 | 148 |
| 7 | Psoas muscle area is not representative of total skeletal muscle area in the assessment of sarcopenia in ovarian cancer | Journal of Cachexia, Sarcopenia and Muscle | 2017 | 144 |
| 8 | Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study | BMC Cancer | 2014 | 143 |
| 9 | Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop | Regulatory Toxicology and Pharmacology | 2017 | 102 |
| 10 | International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer | Nature Reviews Clinical Oncology | 2021 | 93 |
| 11 | Lifestyle, Diet, and Colorectal Cancer Risk According to (Epi)genetic Instability: Current Evidence and Future Directions of Molecular Pathological Epidemiology | Current Colorectal Cancer Reports | 2017 | 91 |
| 12 | Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer | Carcinogenesis | 2008 | 89 |
| 13 | Dietary Flavonoid Intake, Black Tea Consumption, and Risk of Overall and Advanced Stage Prostate Cancer | American Journal of Epidemiology | 2013 | 86 |
| 14 | Preimplantation genetic screening 2.0: the theory | Molecular Human Reproduction | 2016 | 85 |
| 15 | Dietary Folate, Methionine, Riboflavin, and Vitamin B-6 and Risk of Sporadic Colorectal Cancer | Journal of Nutrition | 2008 | 80 |
| 16 | A Single-Nucleotide Deletion in the POMP 5′ UTR Causes a Transcriptional Switch and Altered Epidermal Proteasome Distribution in KLICK Genodermatosis | American Journal of Human Genetics | 2010 | 79 |
| 17 | Psychiatric illness in a cohort of adults with Prader-Willi syndrome | Research in Developmental Disabilities | 2011 | 78 |
| 18 | Consumption of red and processed meat and breast cancer incidence: A systematic review and meta‐analysis of prospective studies | International Journal of Cancer | 2018 | 73 |
| 19 | Porokeratotic Eccrine Nevus May Be Caused by Somatic Connexin26 Mutations | Journal of Investigative Dermatology | 2012 | 71 |
| 20 | Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma | Toxicology | 2016 | 69 |
| 21 | Variants of the FADS1 FADS2 Gene Cluster, Blood Levels of Polyunsaturated Fatty Acids and Eczema in Children within the First 2 Years of Life | PLoS ONE | 2010 | 65 |
| 22 | Body Size, Physical Activity and Risk of Colorectal Cancer with or without the CpG Island Methylator Phenotype (CIMP) | PLoS ONE | 2011 | 64 |
| 23 | Diffusion-weighted MRI to assess response to chemoradiotherapy in rectal cancer: main interpretation pitfalls and their use for teaching | European Radiology | 2017 | 63 |
| 24 | Moving Breast Cancer Therapy up a Notch | Frontiers in Oncology | 2018 | 63 |
| 25 | The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution | Environment International | 2018 | 60 |
| 26 | Associations of sedentary time and patterns of sedentary time accumulation with health-related quality of life in colorectal cancer survivors | Preventive Medicine Reports | 2016 | 58 |
| 27 | Statin Use in Relation to Prostate Cancer Outcomes in a Population-based Patient Cohort Study | Prostate | 2013 | 57 |
| 28 | MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events | Annals of Oncology | 2009 | 56 |
| 29 | Toxicity testing of pesticides in zebrafish—a systematic review on chemicals and associated toxicological endpoints | Environmental Science and Pollution Research | 2020 | 55 |
| 30 | Dietary Acrylamide Intake Is Not Associated with Gastrointestinal Cancer Risk | Journal of Nutrition | 2008 | 53 |
| 31 | A Pattern-Based Approach Combining Tumor Morphology on MRI With Distinct Signal Patterns on Diffusion-Weighted Imaging to Assess Response of Rectal Tumors After Chemoradiotherapy | Diseases of the Colon and Rectum | 2018 | 53 |
| 32 | Contralateral lymph node recurrence in breast cancer: Regional event rather than distant metastatic disease. A systematic review of the literature | European Journal of Surgical Oncology | 2015 | 51 |
| 33 | Introducing the fit-criteria assessment plot – A visualisation tool to assist class enumeration in group-based trajectory modelling | Statistical Methods in Medical Research | 2017 | 51 |
| 34 | ROS networks: designs, aging, Parkinson’s disease and precision therapies | Npj Systems Biology and Applications | 2020 | 50 |
| 35 | Talking to chromatin: post-translational modulation of polycomb group function | Epigenetics and Chromatin | 2009 | 47 |
| 36 | Vegetarianism, low meat consumption and the risk of colorectal cancer in a population based cohort study | Scientific Reports | 2015 | 46 |
| 37 | Timing to achieve the highest rate of pCR after preoperative radiochemotherapy in rectal cancer: a pooled analysis of 3085 patients from 7 randomized trials | Radiotherapy and Oncology | 2021 | 45 |
| 38 | Development of novel tools for thein vitroinvestigation of drug-induced liver injury | Expert Opinion on Drug Metabolism and Toxicology | 2015 | 43 |
| 39 | Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium | Journal of the National Cancer Institute | 2019 | 43 |
| 40 | Radiomics performs comparable to morphologic assessment by expert radiologists for prediction of response to neoadjuvant chemoradiotherapy on baseline staging MRI in rectal cancer | Abdominal Radiology | 2020 | 42 |
| 41 | Light Physical Activity Is Associated with Quality of Life after Colorectal Cancer | Medicine and Science in Sports and Exercise | 2015 | 40 |
| 42 | Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies | Environmental Pollution | 2018 | 40 |
| 43 | Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components | PLoS ONE | 2012 | 38 |
| 44 | Efficacy of Nutritional Intervention in Elderly After Hip Fracture: A Multicenter Randomized Controlled Trial | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2018 | 38 |
| 45 | Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies | Journal of the National Cancer Institute | 2016 | 37 |
| 46 | Adherence to the World Cancer Research Fund/American Institute for Cancer Research lifestyle recommendations in colorectal cancer survivors: results of the PROFILES registry | Cancer Medicine | 2016 | 37 |
| 47 | The association between three major physiological stress systems and oxidative DNA and lipid damage | Psychoneuroendocrinology | 2017 | 37 |
| 48 | Clinical performance of high-risk HPV testing on self-samples versus clinician samples in routine primary HPV screening in the Netherlands: An observational study | Lancet Regional Health - Europe, The | 2021 | 36 |
| 49 | Sleep disturbances and behavioural problems in adults with Prader–Willi syndrome | Journal of Intellectual Disability Research | 2010 | 35 |
| 50 | Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors | Clinical Epigenetics | 2015 | 35 |
