# | Title | Journal | Year | Citations |
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1 | Site-directed mutagenesis by overlap extension using the polymerase chain reaction | Gene | 1989 | 7,939 |
2 | Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension | Gene | 1989 | 2,982 |
3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
4 | Receptor downregulation and multivesicular-body sorting | Nature Reviews Molecular Cell Biology | 2002 | 1,089 |
5 | Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction | BioTechniques | 1990 | 1,047 |
6 | In vivo genome editing using a high-efficiency TALEN system | Nature | 2012 | 849 |
7 | Senescent intimal foam cells are deleterious at all stages of atherosclerosis | Science | 2016 | 824 |
8 | Cellular senescence in ageing: from mechanisms to therapeutic opportunities | Nature Reviews Molecular Cell Biology | 2021 | 812 |
9 | Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map | Nature | 2007 | 806 |
10 | Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline | Nature | 2018 | 803 |
11 | Biological properties of “naked” metal nanoparticles☆ | Advanced Drug Delivery Reviews | 2008 | 771 |
12 | PredictSNP: Robust and Accurate Consensus Classifier for Prediction of Disease-Related Mutations | PLoS Computational Biology | 2014 | 593 |
13 | Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase | Journal of Experimental Medicine | 2002 | 565 |
14 | Foot and mouth: podosomes, invadopodia and circular dorsal ruffles | Nature Reviews Molecular Cell Biology | 2004 | 525 |
15 | Gene Splicing by Overlap Extension: Tailor-Made Genes Using the Polymerase Chain Reaction | BioTechniques | 2013 | 496 |
16 | Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 454 |
17 | Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination | Nature Structural and Molecular Biology | 2013 | 440 |
18 | Gold nanoparticles: opportunities and challenges in nanomedicine | Expert Opinion on Drug Delivery | 2010 | 437 |
19 | Identification of androgen receptors in normal human osteoblast-like cells. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 427 |
20 | Development and characterization of a conditionally immortalized human fetal osteoblastic cell line | Journal of Bone and Mineral Research | 1995 | 411 |
21 | Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma | Nature Medicine | 2014 | 411 |
22 | Acetylation of Histone H3 Lysine 56 Regulates Replication-Coupled Nucleosome Assembly | Cell | 2008 | 406 |
23 | Spectral and photophysical studies of benzo[c]xanthene dyes: Dual emission pH sensors | Analytical Biochemistry | 1991 | 394 |
24 | A Primer for Morpholino Use in Zebrafish | Zebrafish | 2009 | 388 |
25 | Dynamin and its partners: a progress report | Current Opinion in Cell Biology | 1998 | 381 |
26 | Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer | Advanced Drug Delivery Reviews | 2010 | 376 |
27 | Avian osteoclasts as estrogen target cells. | Proceedings of the National Academy of Sciences of the United States of America | 1991 | 361 |
28 | Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape | Journal of Cell Biology | 2000 | 356 |
29 | Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23 | Science | 1996 | 354 |
30 | Mutations in GANAB , Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease | American Journal of Human Genetics | 2016 | 345 |
31 | Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent | Cancer Research | 2008 | 332 |
32 | A Novel Human Prostate-Specific, Androgen-Regulated Homeobox Gene (NKX3.1) That Maps to 8p21, a Region Frequently Deleted in Prostate Cancer | Genomics | 1997 | 331 |
33 | The Ah receptor and the mechanism of dioxin toxicity | Biochemical Journal | 1991 | 323 |
34 | Inorganic Nanoparticles in Cancer Therapy | Pharmaceutical Research | 2011 | 323 |
35 | Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity | Journal of Clinical Investigation | 2012 | 321 |
36 | Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2–ErbB3 receptors | Nature Medicine | 2002 | 298 |
37 | Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy | Nature Genetics | 2010 | 295 |
38 | A Role for Fis1 in Both Mitochondrial and Peroxisomal Fission in Mammalian Cells | Molecular Biology of the Cell | 2005 | 288 |
39 | Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs | Journal of Comparative Neurology | 1994 | 283 |
40 | Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes | Cell Metabolism | 2019 | 277 |
41 | Modulation of Transforming Growth Factor-βProduction in Normal Human Osteoblast-Like Cells by 17β-Estradiol and Parathyroid Hormone | Endocrinology | 1991 | 270 |
42 | The dynamins: Redundant or distinct functions for an expanding family of related GTPases? | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 270 |
43 | Complete primary structure of a human plasma membrane Ca2+ pump | Journal of Biological Chemistry | 1988 | 269 |
44 | Mammalian Dynamin-like Protein DLP1 Tubulates Membranes | Molecular Biology of the Cell | 2001 | 268 |
45 | Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis | Journal of Hepatology | 2021 | 264 |
46 | Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism | Nature | 2015 | 263 |
47 | Temporal and Distinct TGFβ Ligand Requirements during Mouse and Avian Endocardial Cushion Morphogenesis | Developmental Biology | 2002 | 262 |
48 | New insights into pancreatic cancer-induced paraneoplastic diabetes | Nature Reviews Gastroenterology and Hepatology | 2013 | 259 |
49 | ThT 101: a primer on the use of thioflavin T to investigate amyloid formation | Amyloid: the International Journal of Experimental and Clinical Investigation: the Official Journal of the International Society of Amyloidosis | 2017 | 257 |
50 | Dynamin 2 Is Required for Phagocytosis in Macrophages | Journal of Experimental Medicine | 1999 | 252 |