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Department of Molecular Pharmacology and Experimental Therapeutics
›
top-articles
Department of Molecular Pharmacology and Experimental Therapeutics
819
(top 1%)
papers
33.8K
(top 1%)
citations
90
(top 0.1%)
h
-index
147
(top 0.1%)
g
-index
898
all documents
37.0K
doc citations
4.2K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
PARP inhibition: PARP1 and beyond
Nature Reviews Cancer
2010
1,166
2
Pharmacokinetics of Intravitreal Bevacizumab (Avastin)
Ophthalmology
2007
636
3
Genomics and Drug Response
New England Journal of Medicine
2011
552
4
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Nature Neuroscience
2018
490
5
Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
Proceedings of the National Academy of Sciences of the United States of America
2011
475
6
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex
Nature
2017
424
7
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
Blood
2019
408
8
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update
Clinical Pharmacology and Therapeutics
2018
407
9
An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function
Molecular Cell
2007
382
10
Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
Neuroscience
2007
377
11
Methylphenidate: Its Pharmacology and Uses
Mayo Clinic Proceedings
2000
368
12
Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention
JACC: Cardiovascular Interventions
2019
366
13
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
Nature
2011
361
14
ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
Nature Genetics
2004
342
15
Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS
Nature Neuroscience
2015
330
16
The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome
Journal of the American College of Cardiology
2009
303
17
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Nature Genetics
2014
281
18
Ethnic Differences in Cardiac Potassium Channel Variants: Implications for Genetic Susceptibility to Sudden Cardiac Death and Genetic Testing for Congenital Long QT Syndrome
Mayo Clinic Proceedings
2003
273
19
Distinguishing Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia–Associated Mutations From Background Genetic Noise
Journal of the American College of Cardiology
2011
269
20
Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention
JAMA - Journal of the American Medical Association
2020
257
21
Methylphenidate: Its Pharmacology and Uses
Mayo Clinic Proceedings
2000
253
22
Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time—Using Genomic Data to Individualize Treatment Protocol
Mayo Clinic Proceedings
2014
250
23
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for
CYP2D6
and Tamoxifen Therapy
Clinical Pharmacology and Therapeutics
2018
244
24
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
Nature Medicine
2017
240
25
Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ
Journal of Biological Chemistry
2002
239
26
Cardiopoietic programming of embryonic stem cells for tumor-free heart repair
Journal of Experimental Medicine
2007
229
27
Transient outward current (Ito) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome
Heart Rhythm
2011
226
28
Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3
Heart Rhythm
2007
213
29
Histone Deacetylase Inhibitors
Drugs
2009
213
30
Prevalence and Spectrum of Thin Filament Mutations in an Outpatient Referral Population With Hypertrophic Cardiomyopathy
Circulation
2003
210
31
Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas
Blood
2012
208
32
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
Proceedings of the National Academy of Sciences of the United States of America
2013
203
33
Measure transcript integrity using RNA-seq data
BMC Bioinformatics
2016
187
34
Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex
Neurobiology of Aging
2003
185
35
Pharmacometabolomics: Implications for Clinical Pharmacology and Systems Pharmacology
Clinical Pharmacology and Therapeutics
2014
174
36
Prevalence and Severity of “Benign” Mutations in the β-Myosin Heavy Chain, Cardiac Troponin T, and α-Tropomyosin Genes in Hypertrophic Cardiomyopathy
Circulation
2002
173
37
G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cells
Journal of Clinical Investigation
2002
173
38
Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient mice
Journal of Cell Biology
2006
168
39
Molecular and Functional Characterization of Novel Glycerol-3-Phosphate Dehydrogenase 1–Like Gene (
GPD1-L
) Mutations in Sudden Infant Death Syndrome
Circulation
2007
162
40
Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells
Cell
2015
162
41
The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases
International Journal of Molecular Sciences
2018
161
42
ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
Cancer Research
2013
160
43
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion
Oncogene
2008
159
44
Pharmacogenomics: Precision Medicine and Drug Response
Mayo Clinic Proceedings
2017
156
45
Gemcitabine and Cytosine Arabinoside Cytotoxicity: Association with Lymphoblastoid Cell Expression
Cancer Research
2008
155
46
Beta-Poisson model for single-cell RNA-seq data analyses
Bioinformatics
2016
151
47
The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
Immunity
2019
148
48
Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymes
Molecular Psychiatry
2004
146
49
Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed Pharmacogenomics
Clinical Pharmacology and Therapeutics
2011
146
50
Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine
Clinical Pharmacology and Therapeutics
2015
145
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