819(top 1%)
papers
33.8K(top 1%)
citations
90(top 0.1%)
h-index
147(top 0.1%)
g-index
898
all documents
37.0K
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4.2K
citing journals

Top Articles

#TitleJournalYearCitations
1PARP inhibition: PARP1 and beyondNature Reviews Cancer20101,166
2Pharmacokinetics of Intravitreal Bevacizumab (Avastin)Ophthalmology2007636
3Genomics and Drug ResponseNew England Journal of Medicine2011552
4Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disordersNature Neuroscience2018490
5Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cellsProceedings of the National Academy of Sciences of the United States of America2011475
6Phase-plate cryo-EM structure of a class B GPCR–G-protein complexNature2017424
7GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenograftsBlood2019408
8Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 UpdateClinical Pharmacology and Therapeutics2018407
9An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone FunctionMolecular Cell2007382
10Oxidative stress and mitochondrial dysfunction in neurodegenerative diseasesNeuroscience2007377
11Methylphenidate: Its Pharmacology and UsesMayo Clinic Proceedings2000368
12Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary InterventionJACC: Cardiovascular Interventions2019366
13MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sitesNature2011361
14ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gatingNature Genetics2004342
15Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALSNature Neuroscience2015330
16The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT SyndromeJournal of the American College of Cardiology2009303
17Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarizationNature Genetics2014281
18Ethnic Differences in Cardiac Potassium Channel Variants: Implications for Genetic Susceptibility to Sudden Cardiac Death and Genetic Testing for Congenital Long QT SyndromeMayo Clinic Proceedings2003273
19Distinguishing Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia–Associated Mutations From Background Genetic NoiseJournal of the American College of Cardiology2011269
20Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary InterventionJAMA - Journal of the American Medical Association2020257
21Methylphenidate: Its Pharmacology and UsesMayo Clinic Proceedings2000253
22Preemptive Genotyping for Personalized Medicine: Design of the Right Drug, Right Dose, Right Time—Using Genomic Data to Individualize Treatment ProtocolMayo Clinic Proceedings2014250
23Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen TherapyClinical Pharmacology and Therapeutics2018244
24Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4Nature Medicine2017240
25Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in SituJournal of Biological Chemistry2002239
26Cardiopoietic programming of embryonic stem cells for tumor-free heart repairJournal of Experimental Medicine2007229
27Transient outward current (Ito) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndromeHeart Rhythm2011226
28Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3Heart Rhythm2007213
29Histone Deacetylase InhibitorsDrugs2009213
30Prevalence and Spectrum of Thin Filament Mutations in an Outpatient Referral Population With Hypertrophic CardiomyopathyCirculation2003210
31Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomasBlood2012208
32Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformationsProceedings of the National Academy of Sciences of the United States of America2013203
33Measure transcript integrity using RNA-seq dataBMC Bioinformatics2016187
34Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortexNeurobiology of Aging2003185
35Pharmacometabolomics: Implications for Clinical Pharmacology and Systems PharmacologyClinical Pharmacology and Therapeutics2014174
36Prevalence and Severity of “Benign” Mutations in the β-Myosin Heavy Chain, Cardiac Troponin T, and α-Tropomyosin Genes in Hypertrophic CardiomyopathyCirculation2002173
37G1 and G2 cell-cycle arrest following microtubule depolymerization in human breast cancer cellsJournal of Clinical Investigation2002173
38Early aging–associated phenotypes in Bub3/Rae1 haploinsufficient miceJournal of Cell Biology2006168
39Molecular and Functional Characterization of Novel Glycerol-3-Phosphate Dehydrogenase 1–Like Gene ( GPD1-L ) Mutations in Sudden Infant Death SyndromeCirculation2007162
40Systematic Identification of Factors for Provirus Silencing in Embryonic Stem CellsCell2015162
41The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory DiseasesInternational Journal of Molecular Sciences2018161
42ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA StatusCancer Research2013160
43A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasionOncogene2008159
44Pharmacogenomics: Precision Medicine and Drug ResponseMayo Clinic Proceedings2017156
45Gemcitabine and Cytosine Arabinoside Cytotoxicity: Association with Lymphoblastoid Cell ExpressionCancer Research2008155
46Beta-Poisson model for single-cell RNA-seq data analysesBioinformatics2016151
47The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and FunctionalityImmunity2019148
48Human catechol O-methyltransferase genetic variation: gene resequencing and functional characterization of variant allozymesMolecular Psychiatry2004146
49Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-Informed PharmacogenomicsClinical Pharmacology and Therapeutics2011146
50Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision MedicineClinical Pharmacology and Therapeutics2015145