| # | Title | Journal | Year | Citations |
|---|
| 1 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 2 | Changes in Burnout and Satisfaction With Work-Life Balance in Physicians and the General US Working Population Between 2011 and 2014 | Mayo Clinic Proceedings | 2015 | 1,982 |
| 3 | iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics | Lancet Oncology, The | 2017 | 1,612 |
| 4 | Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer | Journal of Clinical Oncology | 2010 | 1,352 |
| 5 | RECIST 1.1—Update and clarification: From the RECIST committee | European Journal of Cancer | 2016 | 1,143 |
| 6 | Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States | Gastroenterology | 2011 | 1,006 |
| 7 | Characterization of human plasma-derived exosomal RNAs by deep sequencing | BMC Genomics | 2013 | 860 |
| 8 | Genome partitioning of genetic variation for complex traits using common SNPs | Nature Genetics | 2011 | 834 |
| 9 | GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment | Science | 2013 | 750 |
| 10 | Relationship Between Clerical Burden and Characteristics of the Electronic Environment With Physician Burnout and Professional Satisfaction | Mayo Clinic Proceedings | 2016 | 739 |
| 11 | New loci associated with kidney function and chronic kidney disease | Nature Genetics | 2010 | 710 |
| 12 | History of the Rochester Epidemiology Project: Half a Century of Medical Records Linkage in a US Population | Mayo Clinic Proceedings | 2012 | 684 |
| 13 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 14 | From genome-wide associations to candidate causal variants by statistical fine-mapping | Nature Reviews Genetics | 2018 | 611 |
| 15 | Risk Factors Associated With Progression to Intestinal Complications of Crohn's Disease in a Population-Based Cohort | Gastroenterology | 2010 | 597 |
| 16 | Premature menopause or early menopause: Long-term health consequences | Maturitas | 2010 | 596 |
| 17 | An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis | Genome Medicine | 2016 | 596 |
| 18 | Intervention to Promote Physician Well-being, Job Satisfaction, and Professionalism | JAMA Internal Medicine | 2014 | 559 |
| 19 | Generalizability of Epidemiological Findings and Public Health Decisions: An Illustration From the Rochester Epidemiology Project | Mayo Clinic Proceedings | 2012 | 556 |
| 20 | Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations Based on Individual Patient Data From 20,898 Patients on 18 Randomized Trials | Journal of Clinical Oncology | 2009 | 539 |
| 21 | Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer | European Urology | 2015 | 533 |
| 22 | Detectable clonal mosaicism from birth to old age and its relationship to cancer | Nature Genetics | 2012 | 511 |
| 23 | Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients | American Journal of Transplantation | 2011 | 507 |
| 24 | Single Item Measures of Emotional Exhaustion and Depersonalization Are Useful for Assessing Burnout in Medical Professionals | Journal of General Internal Medicine | 2009 | 504 |
| 25 | Clinical information extraction applications: A literature review | Journal of Biomedical Informatics | 2018 | 502 |
| 26 | Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer | Nature Genetics | 2013 | 493 |
| 27 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array | Nature Genetics | 2013 | 492 |
| 28 | 40-Year Follow-Up After the Fontan Operation | Journal of the American College of Cardiology | 2015 | 484 |
| 29 | Natural History of Wild-Type Transthyretin Cardiac Amyloidosis and Risk Stratification Using a Novel Staging System | Journal of the American College of Cardiology | 2016 | 460 |
| 30 | Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database | Lancet Oncology, The | 2016 | 442 |
| 31 | Physician Satisfaction and Burnout at Different Career Stages | Mayo Clinic Proceedings | 2013 | 426 |
| 32 | Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors | Mayo Clinic Proceedings | 2018 | 416 |
| 33 | Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function | Nature Communications | 2016 | 412 |
| 34 | Prognostic Value of Flow‐Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta‐Analysis | Journal of the American Heart Association | 2015 | 391 |
| 35 | Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study | Lancet Oncology, The | 2010 | 390 |
| 36 | A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function | Gastroenterology | 2013 | 386 |
| 37 | Plasma phospho‐tau181 increases with Alzheimer's disease clinical severity and is associated with tau‐ and amyloid‐positron emission tomography | Alzheimer's and Dementia | 2018 | 386 |
| 38 | Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans | Cell Metabolism | 2017 | 381 |
| 39 | Concurrent Validity of Single-Item Measures of Emotional Exhaustion and Depersonalization in Burnout Assessment | Journal of General Internal Medicine | 2012 | 371 |
| 40 | Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer | Nature Genetics | 2017 | 356 |
| 41 | A clinical text classification paradigm using weak supervision and deep representation | BMC Medical Informatics and Decision Making | 2019 | 348 |
| 42 | Standards and Guidelines for Validating Next-Generation Sequencing Bioinformatics Pipelines | Journal of Molecular Diagnostics | 2018 | 341 |
| 43 | Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study | Lancet Neurology, The | 2013 | 335 |
| 44 | GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer | Nature Genetics | 2013 | 326 |
| 45 | Incidence of Hidradenitis Suppurativa and Associated Factors: A Population-Based Study of Olmsted County, Minnesota | Journal of Investigative Dermatology | 2013 | 321 |
| 46 | Association of Clinical Specialty With Symptoms of Burnout and Career Choice Regret Among US Resident Physicians | JAMA - Journal of the American Medical Association | 2018 | 305 |
| 47 | PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study | Lancet Diabetes and Endocrinology,the | 2017 | 298 |
| 48 | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer | Nature Genetics | 2014 | 294 |
| 49 | Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia | JAMA Neurology | 2016 | 294 |
| 50 | A Phase II Trial of Neoadjuvant Chemoradiation and Local Excision for T2N0 Rectal Cancer: Preliminary Results of the ACOSOG Z6041 Trial | Annals of Surgical Oncology | 2012 | 291 |
