| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers | Lancet Neurology, The | 2013 | 3,528 |
| 2 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,758 |
| 3 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,178 |
| 4 | Changes in Burnout and Satisfaction With Work-Life Balance in Physicians and the General US Working Population Between 2011 and 2014 | Mayo Clinic Proceedings | 2015 | 2,055 |
| 5 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,756 |
| 6 | iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics | Lancet Oncology, The | 2017 | 1,733 |
| 7 | Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with aFLT3Mutation | New England Journal of Medicine | 2017 | 1,715 |
| 8 | Interventions to prevent and reduce physician burnout: a systematic review and meta-analysis | Lancet, The | 2016 | 1,598 |
| 9 | International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study | Lancet, The | 2018 | 1,570 |
| 10 | Burnout Among U.S. Medical Students, Residents, and Early Career Physicians Relative to the General U.S. Population | Academic Medicine | 2014 | 1,498 |
| 11 | Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases | Cancer | 1986 | 1,436 |
| 12 | Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer | Journal of Clinical Oncology | 2010 | 1,398 |
| 13 | Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases | JAMA - Journal of the American Medical Association | 2016 | 1,296 |
| 14 | RECIST 1.1—Update and clarification: From the RECIST committee | European Journal of Cancer | 2016 | 1,251 |
| 15 | Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States | Gastroenterology | 2011 | 1,020 |
| 16 | The Epidemiology of Epilepsy in Rochester, Minnesota, 1935 Through 1967 | Epilepsia | 1975 | 979 |
| 17 | Mean Amplitude of Glycemic Excursions, a Measure of Diabetic Instability | Diabetes | 1970 | 970 |
| 18 | Effect of Laparoscopic-Assisted Resection vs Open Resection of Stage II or III Rectal Cancer on Pathologic Outcomes | JAMA - Journal of the American Medical Association | 2015 | 933 |
| 19 | Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial | Lancet Oncology, The | 2017 | 902 |
| 20 | Characterization of human plasma-derived exosomal RNAs by deep sequencing | BMC Genomics | 2013 | 899 |
| 21 | Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data | Nature Biotechnology | 2013 | 883 |
| 22 | Genome partitioning of genetic variation for complex traits using common SNPs | Nature Genetics | 2011 | 855 |
| 23 | Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma | New England Journal of Medicine | 2016 | 853 |
| 24 | Grading of astrocytomas: A simple and reproducible method | Cancer | 1988 | 843 |
| 25 | Relationship Between Clerical Burden and Characteristics of the Electronic Environment With Physician Burnout and Professional Satisfaction | Mayo Clinic Proceedings | 2016 | 778 |
| 26 | Clinical Features, Management, and Prognosis of Spontaneous Coronary Artery Dissection | Circulation | 2012 | 760 |
| 27 | Duration of Adjuvant Chemotherapy for Stage III Colon Cancer | New England Journal of Medicine | 2018 | 750 |
| 28 | Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL | New England Journal of Medicine | 2018 | 742 |
| 29 | New loci associated with kidney function and chronic kidney disease | Nature Genetics | 2010 | 722 |
| 30 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 706 |
| 31 | Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls | Scientific Reports | 2016 | 701 |
| 32 | Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer | JAMA - Journal of the American Medical Association | 2017 | 699 |
| 33 | Increased Prevalence and Mortality in Undiagnosed Celiac Disease | Gastroenterology | 2009 | 687 |
| 34 | CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set | Cancer Research | 2012 | 687 |
| 35 | From genome-wide associations to candidate causal variants by statistical fine-mapping | Nature Reviews Genetics | 2018 | 678 |
| 36 | Screening for Lung Cancer with Low-Dose Spiral Computed Tomography | American Journal of Respiratory and Critical Care Medicine | 2002 | 651 |
| 37 | An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis | Genome Medicine | 2016 | 628 |
| 38 | The eMERGE Network: A consortium of biorepositories linked to electronic medical records data for conducting genomic studies | BMC Medical Genomics | 2011 | 624 |
| 39 | Risk Factors Associated With Progression to Intestinal Complications of Crohn's Disease in a Population-Based Cohort | Gastroenterology | 2010 | 623 |
| 40 | Premature menopause or early menopause: Long-term health consequences | Maturitas | 2010 | 617 |
| 41 | Prevalence of mild cognitive impairment is higher in men | Neurology | 2010 | 616 |
| 42 | Remission of Seizures and Relapse in Patients with Epilepsy | Epilepsia | 1979 | 605 |
| 43 | Intervention to Promote Physician Well-being, Job Satisfaction, and Professionalism | JAMA Internal Medicine | 2014 | 572 |
| 44 | Generalizability of Epidemiological Findings and Public Health Decisions: An Illustration From the Rochester Epidemiology Project | Mayo Clinic Proceedings | 2012 | 564 |
| 45 | Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer | European Urology | 2015 | 564 |
| 46 | Evidence for Cure by Adjuvant Therapy in Colon Cancer: Observations Based on Individual Patient Data From 20,898 Patients on 18 Randomized Trials | Journal of Clinical Oncology | 2009 | 556 |
| 47 | Clinical information extraction applications: A literature review | Journal of Biomedical Informatics | 2018 | 546 |
| 48 | Nivolumab with or without ipilimumab treatment for metastatic sarcoma (Alliance A091401): two open-label, non-comparative, randomised, phase 2 trials | Lancet Oncology, The | 2018 | 542 |
| 49 | Data Resource Profile: The Rochester Epidemiology Project (REP) medical records-linkage system | International Journal of Epidemiology | 2012 | 536 |
| 50 | An operational approach to National Institute on Aging–Alzheimer's Association criteria for preclinical Alzheimer disease | Annals of Neurology | 2012 | 530 |
