| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2007 WHO Classification of Tumours of the Central Nervous System | Acta Neuropathologica | 2007 | 9,898 |
| 2 | Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion | Nature Medicine | 2002 | 4,217 |
| 3 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 4 | Detection and localization of surgically resectable cancers with a multi-analyte blood test | Science | 2018 | 1,872 |
| 5 | Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease | Nature Genetics | 2011 | 1,676 |
| 6 | REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants | American Journal of Human Genetics | 2016 | 1,555 |
| 7 | The New WHO Classification of Brain Tumours | Brain Pathology | 1993 | 1,480 |
| 8 | Senolytics improve physical function and increase lifespan in old age | Nature Medicine | 2018 | 1,384 |
| 9 | Real-Time PCR in Clinical Microbiology: Applications for Routine Laboratory Testing | Clinical Microbiology Reviews | 2006 | 1,109 |
| 10 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 11 | Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex | Nature Genetics | 2000 | 1,091 |
| 12 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 13 | An Update on Terminology and Reporting | American Journal of Surgical Pathology | 1995 | 988 |
| 14 | Large-scale genotyping identifies 41 new loci associated with breast cancer risk | Nature Genetics | 2013 | 960 |
| 15 | Comparisons of Outcome and Prognostic Features Among Histologic Subtypes of Renal Cell Carcinoma | American Journal of Surgical Pathology | 2003 | 952 |
| 16 | Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers | Nature | 2008 | 934 |
| 17 | Characterization of human plasma-derived exosomal RNAs by deep sequencing | BMC Genomics | 2013 | 860 |
| 18 | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Cancer Cell | 2017 | 836 |
| 19 | von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)1 | Haemophilia | 2008 | 815 |
| 20 | The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell–mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials | American Journal of Transplantation | 2018 | 813 |
| 21 | Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology | Journal of Thoracic Oncology | 2013 | 792 |
| 22 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 23 | Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient | PLoS Medicine | 2009 | 780 |
| 24 | Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies | PLoS Medicine | 2010 | 764 |
| 25 | Classification of amyloidosis by laser microdissection and mass spectrometry–based proteomic analysis in clinical biopsy specimens | Blood | 2009 | 746 |
| 26 | Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors | Clinical Pharmacology and Therapeutics | 2015 | 739 |
| 27 | Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes | American Journal of Human Genetics | 2019 | 711 |
| 28 | Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization | Cell Host and Microbe | 2021 | 700 |
| 29 | Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group | Blood | 2016 | 686 |
| 30 | The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein | Nature Genetics | 2002 | 683 |
| 31 | Increased Prevalence and Mortality in Undiagnosed Celiac Disease | Gastroenterology | 2009 | 675 |
| 32 | Papillary Thyroid Carcinoma Managed at the Mayo Clinic during Six Decades (1940-1999): Temporal Trends in Initial Therapy and Long-term Outcome in 2444 Consecutively Treated Patients | World Journal of Surgery | 2002 | 663 |
| 33 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 34 | Screening for Lung Cancer with Low-Dose Spiral Computed Tomography | American Journal of Respiratory and Critical Care Medicine | 2002 | 649 |
| 35 | Deployment of convalescent plasma for the prevention and treatment of COVID-19 | Journal of Clinical Investigation | 2020 | 649 |
| 36 | Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry: a Fundamental Shift in the Routine Practice of Clinical Microbiology | Clinical Microbiology Reviews | 2013 | 644 |
| 37 | The Epidemiology of Venous Thromboembolism in the Community | Arteriosclerosis, Thrombosis, and Vascular Biology | 2008 | 636 |
| 38 | Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability | Cancer Research | 1998 | 630 |
| 39 | Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology | Nature Genetics | 2021 | 629 |
| 40 | Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections | Nature Reviews Microbiology | 2021 | 617 |
| 41 | The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex | Nature Genetics | 2013 | 601 |
| 42 | cIMPACT-NOW update 3: recommended diagnostic criteria for “Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV” | Acta Neuropathologica | 2018 | 599 |
| 43 | Radical Nephrectomy for pT1a Renal Masses May be Associated With Decreased Overall Survival Compared With Partial Nephrectomy | Journal of Urology | 2008 | 589 |
| 44 | Newborn Screening for Severe Combined Immunodeficiency in 11 Screening Programs in the United States | JAMA - Journal of the American Medical Association | 2014 | 586 |
| 45 | Analysis of Circulating MicroRNA: Preanalytical and Analytical Challenges | Clinical Chemistry | 2011 | 577 |
| 46 | Idiopathic Chronic Pancreatitis With Periductal Lymphoplasmacytic Infiltration | American Journal of Surgical Pathology | 2003 | 552 |
| 47 | The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology | American Journal of Transplantation | 2017 | 551 |
| 48 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche | Nature | 2014 | 548 |
| 49 | Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection | Ophthalmology | 2003 | 541 |
| 50 | Exosomal miR-1290 and miR-375 as Prognostic Markers in Castration-resistant Prostate Cancer | European Urology | 2015 | 533 |
