| # | Title | Journal | Year | Citations |
|---|
| 1 | NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines | Annual Review of Immunology | 1999 | 1,879 |
| 2 | Two networks of electrically coupled inhibitory neurons in neocortex | Nature | 1999 | 1,314 |
| 3 | Intrinsic firing patterns of diverse neocortical neurons | Trends in Neurosciences | 1990 | 1,269 |
| 4 | TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection | Immunity | 2003 | 1,037 |
| 5 | Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology | Nature Immunology | 2001 | 912 |
| 6 | Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body | Nature | 2004 | 873 |
| 7 | Biologically erodable microspheres as potential oral drug delivery systems | Nature | 1997 | 808 |
| 8 | Type 1 Interferons and the Virus-Host Relationship: A Lesson in Detente | Science | 2006 | 765 |
| 9 | Empirical estimation of protein-induced DNA bending angles: applications to λ site-specific recombination complexes | Nucleic Acids Research | 1988 | 723 |
| 10 | The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions | Brain Research Reviews | 1997 | 714 |
| 11 | Targeting natural killer cells and natural killer T cells in cancer | Nature Reviews Immunology | 2012 | 707 |
| 12 | Thalamocortical responses of mouse somatosensory (barrel) cortexin vitro | Neuroscience | 1991 | 658 |
| 13 | T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells | Immunity | 2004 | 649 |
| 14 | Interferons α and β as Immune Regulators—A New Look | Immunity | 2001 | 634 |
| 15 | Dynamic, Structural, and Regulatory Aspects of lambda Site-Specific Recombination | Annual Review of Biochemistry | 1989 | 628 |
| 16 | Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A | Cell | 1990 | 628 |
| 17 | Intrinsic oscillations of neocortex generated by layer 5 pyramidal neurons | Science | 1991 | 615 |
| 18 | Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation | Science | 1992 | 606 |
| 19 | Two Dynamically Distinct Inhibitory Networks in Layer 4 of the Neocortex | Journal of Neurophysiology | 2003 | 530 |
| 20 | Dual Function of the Damselfly Penis: Sperm Removal and Transfer | Science | 1979 | 514 |
| 21 | Neural Discharge and Local Field Potential Oscillations in Primate Motor Cortex During Voluntary Movements | Journal of Neurophysiology | 1998 | 496 |
| 22 | RAPID SCREENING METHOD TO DETECT POTENTIAL BIPARENTAL INHERITANCE OF PLASTID DNA AND RESULTS FOR OVER 200 ANGIOSPERM SPECIES | American Journal of Botany | 1988 | 471 |
| 23 | Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-gamma Response to Viral Infection | Science | 2002 | 443 |
| 24 | Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. | Journal of Experimental Medicine | 1995 | 441 |
| 25 | Shared neural substrates controlling hand movements in human motor cortex | Science | 1995 | 439 |
| 26 | Similarities and differences among 105 members of the Int family of site-specific recombinases | Nucleic Acids Research | 1998 | 429 |
| 27 | Hormonal pleiotropy and the juvenile hormone regulation ofDrosophila development and life history | BioEssays | 2005 | 422 |
| 28 | Interferon α/β and Interleukin 12 Responses to Viral Infections | Journal of Experimental Medicine | 2002 | 421 |
| 29 | Enzymes of chlorophyll biosynthesis | Photosynthesis Research | 1999 | 418 |
| 30 | Immune Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis during Viral Infection | Viral Immunology | 2005 | 399 |
| 31 | Selective Release of Multiple DNA Oligonucleotides from Gold Nanorods | ACS Nano | 2009 | 395 |
| 32 | The Evolutionary Genetics of Canalization | Quarterly Review of Biology | 2005 | 382 |
| 33 | Is there a molecular key to the level of “biological species” in eukaryotes? A DNA guide | Molecular Phylogenetics and Evolution | 2009 | 368 |
| 34 | A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain | Brain Research | 1990 | 366 |
| 35 | Electrical Synapses in the Thalamic Reticular Nucleus | Journal of Neuroscience | 2002 | 366 |
| 36 | ON THE MEANS WHEREBY MAMMALS ACHIEVE INCREASED FUNCTIONAL DURABILITY OF THEIR DENTITIONS, WITH SPECIAL REFERENCE TO LIMITING FACTORS | Biological Reviews | 1988 | 365 |
| 37 | Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex | Journal of Neurophysiology | 1989 | 361 |
| 38 | Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways | Journal of Experimental Medicine | 1998 | 357 |
| 39 | mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function | Journal of Immunology | 2014 | 355 |
| 40 | Regulation of cyclin-Cdk activity in mammalian cells | Cellular and Molecular Life Sciences | 2002 | 347 |
| 41 | Evolution of hybrid dysgenesis determinants in Drosophila melanogaster | Proceedings of the National Academy of Sciences of the United States of America | 1983 | 346 |
| 42 | Pan-eukaryote ITS2 homologies revealed by RNA secondary structure | Nucleic Acids Research | 2007 | 338 |
| 43 | Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection. | Journal of Immunology | 1996 | 337 |
| 44 | Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages | Journal of Experimental Medicine | 2006 | 332 |
| 45 | Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study | Gut | 2013 | 330 |
| 46 | Dendritic Cell Responses to Early Murine Cytomegalovirus Infection | Journal of Experimental Medicine | 2003 | 316 |
| 47 | Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection | Journal of Immunology | 1996 | 314 |
| 48 | Viral integration and excision: structure of the lambda att sites | Science | 1977 | 311 |
| 49 | Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection | Journal of Experimental Medicine | 2001 | 311 |
| 50 | Efficacy of Thalamocortical and Intracortical Synaptic Connections | Neuron | 1999 | 310 |
