| # | Title | Journal | Year | Citations |
|---|
| 1 | Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity | Journal of Clinical Investigation | 1999 | 1,063 |
| 2 | Tissue-Engineered Lungs for in Vivo Implantation | Science | 2010 | 1,062 |
| 3 | Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document | Journal of Hepatology | 2000 | 838 |
| 4 | The Patient Who Falls | JAMA - Journal of the American Medical Association | 2010 | 767 |
| 5 | Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study | Lancet Psychiatry,the | 2018 | 658 |
| 6 | IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine | Nature | 2012 | 641 |
| 7 | Expression of heme oxygenase-1 can determine cardiac xenograft survival | Nature Medicine | 1998 | 601 |
| 8 | Visualizing structure and transitions in high-dimensional biological data | Nature Biotechnology | 2019 | 597 |
| 9 | Alu sequences are processed 7SL RNA genes | Nature | 1984 | 579 |
| 10 | Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus | Science | 1981 | 571 |
| 11 | Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes | Cell | 2015 | 547 |
| 12 | Variability in Radiologists' Interpretations of Mammograms | New England Journal of Medicine | 1994 | 542 |
| 13 | An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore | Proceedings of the National Academy of Sciences of the United States of America | 2014 | 502 |
| 14 | Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo. | Proceedings of the National Academy of Sciences of the United States of America | 1993 | 495 |
| 15 | Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2020 | 481 |
| 16 | Change in Disability After Hospitalization or Restricted Activity in Older Persons | JAMA - Journal of the American Medical Association | 2010 | 422 |
| 17 | Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors | Diabetes | 2018 | 386 |
| 18 | Assembly of the tight junction: the role of diacylglycerol. | Journal of Cell Biology | 1993 | 377 |
| 19 | Humoral Hypercalcemia of Cancer | New England Journal of Medicine | 1988 | 357 |
| 20 | Cardiovascular disease in neurofibromatosis 1: Report of the NF1 Cardiovascular Task Force | Genetics in Medicine | 2002 | 330 |
| 21 | Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases | Hepatology | 2021 | 311 |
| 22 | Gut Microbiota of the Tick Vector Ixodes scapularis Modulate Colonization of the Lyme Disease Spirochete | Cell Host and Microbe | 2014 | 299 |
| 23 | Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases | Hepatology | 2021 | 295 |
| 24 | Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon | Gastroenterology | 1989 | 285 |
| 25 | Cholangiocyte pathobiology | Nature Reviews Gastroenterology and Hepatology | 2019 | 285 |
| 26 | Adherence in AIDS clinical trials: A framework for clinical research and clinical care | Journal of Clinical Epidemiology | 1997 | 273 |
| 27 | Insulin secretion: Combined effects of phorbol ester and A23187 | Biochemical and Biophysical Research Communications | 1983 | 263 |
| 28 | Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia | Gastroenterology | 1987 | 261 |
| 29 | A Role of the Lowe Syndrome Protein OCRL in Early Steps of the Endocytic Pathway | Developmental Cell | 2007 | 258 |
| 30 | Drug Interactions of Clinical Importance among the Opioids, Methadone and Buprenorphine, and Other Frequently Prescribed Medications: A Review | American Journal on Addictions | 2010 | 258 |
| 31 | Tick microbiome: the force within | Trends in Parasitology | 2015 | 258 |
| 32 | Extracellular metabolites in the cortex and hippocampus of epileptic patients | Annals of Neurology | 2005 | 255 |
| 33 | Outcomes of COVID-19 in patients with CLL: a multicenter international experience | Blood | 2020 | 248 |
| 34 | Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase | Nature Cell Biology | 2011 | 245 |
| 35 | Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis | Development (Cambridge) | 2004 | 243 |
| 36 | The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide Resolution | PLoS Pathogens | 2010 | 243 |
| 37 | Effect of Bile Salts and Fatty Acids on the Colonic Absorption of Oxalate | Gastroenterology | 1976 | 238 |
| 38 | Nonsense mutations in the human beta-globin gene affect mRNA metabolism. | Proceedings of the National Academy of Sciences of the United States of America | 1988 | 234 |
| 39 | Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity | Circulation | 2013 | 231 |
| 40 | A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe | Lancet, The | 2013 | 224 |
| 41 | The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases | Journal of the American Geriatrics Society | 2015 | 224 |
| 42 | Abnormal Liver Function Tests in Patients With COVID‐19: Relevance and Potential Pathogenesis | Hepatology | 2020 | 221 |
| 43 | Macrophages in Renal Injury and Repair | Annual Review of Physiology | 2017 | 220 |
| 44 | Frailty and Subsequent Disability and Mortality among Patients with Critical Illness | American Journal of Respiratory and Critical Care Medicine | 2017 | 219 |
| 45 | Expression of Messenger Ribonucleic Acids Encoding a Parathyroid Hormone-Like Peptide in Normal Human and Animal Tissues with Abnormal Expression in Human Parathyroid Adenomas | Molecular Endocrinology | 1988 | 217 |
| 46 | The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer | Journal of Thoracic Oncology | 2016 | 211 |
| 47 | Self-efficacy, Physical Decline, and Change in Functioning in Community-Living Elders: A Prospective Study | Journals of Gerontology - Series B Psychological Sciences and Social Sciences | 1996 | 209 |
| 48 | Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity | Journal of Cell Biology | 2016 | 205 |
| 49 | Bcl-xL increases mitochondrial fission, fusion, and biomass in neurons | Journal of Cell Biology | 2009 | 203 |
| 50 | On the dark rim artifact in dynamic contrast-enhanced MRI myocardial perfusion studies | Magnetic Resonance in Medicine | 2005 | 201 |
