| # | Title | Journal | Year | Citations |
|---|
| 1 | CYTOCHEMISTRY AND ELECTRON MICROSCOPY | Journal of Cell Biology | 1963 | 4,101 |
| 2 | Social class and mental illness: Community study. | | 1958 | 3,297 |
| 3 | X-Tile | Clinical Cancer Research | 2004 | 2,925 |
| 4 | A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury | New England Journal of Medicine | 1990 | 2,680 |
| 5 | Neonatal Outcomes of Extremely Preterm Infants From the NICHD Neonatal Research Network | Pediatrics | 2010 | 2,252 |
| 6 | Single-channel currents recorded from membrane of denervated frog muscle fibres | Nature | 1976 | 2,196 |
| 7 | Three types of neuronal calcium channel with different calcium agonist sensitivity | Nature | 1985 | 2,140 |
| 8 | Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU | Critical Care Medicine | 2018 | 2,074 |
| 9 | Two Shorter Forms of the CES-D Depression Symptoms Index | Journal of Aging and Health | 1993 | 1,864 |
| 10 | Regulation of Adaptive Immunity by the Innate Immune System | Science | 2010 | 1,762 |
| 11 | Children's Yale-Brown Obsessive Compulsive Scale: Reliability and Validity | Journal of the American Academy of Child and Adolescent Psychiatry | 1997 | 1,725 |
| 12 | High resolution of human evolutionary trees with polymorphic microsatellites | Nature | 1994 | 1,700 |
| 13 | The Stabilizing System of the Spine. Part I. Function, Dysfunction, Adaptation, and Enhancement | Journal of Spinal Disorders | 1992 | 1,684 |
| 14 | Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms | Nature Reviews Cancer | 2013 | 1,497 |
| 15 | The crystal structure of the bacterial chaperonln GroEL at 2.8 Å | Nature | 1994 | 1,363 |
| 16 | Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists | Nature | 1984 | 1,307 |
| 17 | The Stabilizing System of the Spine. Part II. Neutral Zone and Instability Hypothesis | Journal of Spinal Disorders | 1992 | 1,279 |
| 18 | Mutation detection and single-molecule counting using isothermal rolling-circle amplification | Nature Genetics | 1998 | 1,273 |
| 19 | Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 1,257 |
| 20 | Expanded encyclopaedias of DNA elements in the human and mouse genomes | Nature | 2020 | 1,252 |
| 21 | Liver from bone marrow in humans | Hepatology | 2000 | 1,185 |
| 22 | New regulators of NF-κB in inflammation | Nature Reviews Immunology | 2008 | 1,163 |
| 23 | A cyclic nucleotide-gated conductance in olfactory receptor cilia | Nature | 1987 | 1,123 |
| 24 | Mitochondria in innate immune responses | Nature Reviews Immunology | 2011 | 1,062 |
| 25 | REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity | American Journal of Reproductive Immunology | 2010 | 1,059 |
| 26 | Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma | Nature Genetics | 2012 | 1,052 |
| 27 | Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase | Nature | 2014 | 989 |
| 28 | Voltage Dependent Charge Movement in Skeletal Muscle: a Possible Step in Excitation–Contraction Coupling | Nature | 1973 | 955 |
| 29 | Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation | Hepatology | 2000 | 945 |
| 30 | Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms | Journal of Neurophysiology | 1991 | 940 |
| 31 | Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia | NeuroImage: Clinical | 2014 | 925 |
| 32 | Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis | Journal of Experimental Medicine | 2000 | 910 |
| 33 | Developmental history of the transient subplate zone in the visual and somatosensory cortex of the macaque monkey and human brain | Journal of Comparative Neurology | 1990 | 889 |
| 34 | Protein blotting: Principles and applications | Analytical Biochemistry | 1983 | 886 |
| 35 | Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies | Lancet, The | 2018 | 858 |
| 36 | Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells | Nature | 1983 | 851 |
| 37 | Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial | Lancet Oncology, The | 2016 | 846 |
| 38 | Expression cloning of a mammalian proton-coupled oligopeptide transporter | Nature | 1994 | 838 |
| 39 | Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain | Lancet, The | 1993 | 836 |
| 40 | Analysis of Transcription Factor HY5 Genomic Binding Sites Revealed Its Hierarchical Role in Light Regulation of Development | Plant Cell | 2007 | 829 |
| 41 | Inflammation and pregnancy: the role of the immune system at the implantation site | Annals of the New York Academy of Sciences | 2011 | 825 |
| 42 | Mechanism of ion permeation through calcium channels | Nature | 1984 | 821 |
| 43 | A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle | Nature | 1987 | 797 |
| 44 | Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes | Nature Genetics | 2002 | 784 |
| 45 | A novel type of cardiac calcium channel in ventricular cells | Nature | 1985 | 735 |
| 46 | Microarray analysis of microRNA expression in the developing mammalian brain | Genome Biology | 2004 | 710 |
| 47 | Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters† | Nature | 1976 | 705 |
| 48 | Outcomes of epilepsy surgery in adults and children | Lancet Neurology, The | 2008 | 704 |
| 49 | Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells | Nature Medicine | 2013 | 700 |
| 50 | ACR Guidance Document for Safe MR Practices: 2007 | American Journal of Roentgenology | 2007 | 699 |
