| # | Title | Journal | Year | Citations |
|---|
| 1 | Hepatocellular carcinoma | Nature Reviews Disease Primers | 2021 | 2,757 |
| 2 | Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update | Hepatology International | 2017 | 1,537 |
| 3 | Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas | Pancreatology | 2017 | 1,208 |
| 4 | Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan | Annals of Internal Medicine | 1999 | 1,038 |
| 5 | Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma | Hepatology International | 2010 | 944 |
| 6 | A Randomized Controlled Trial of Radiofrequency Ablation With Ethanol Injection for Small Hepatocellular Carcinoma | Gastroenterology | 2005 | 831 |
| 7 | Percutaneous radiofrequency ablation for hepatocellular carcinoma | Cancer | 2005 | 756 |
| 8 | Prospective Cohort Study of Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma in 8510 Patients | Gastroenterology | 2006 | 733 |
| 9 | Radiofrequency Ablation for Hepatocellular Carcinoma: 10-Year Outcome and Prognostic Factors | American Journal of Gastroenterology | 2012 | 604 |
| 10 | A prospective randomised study of "covered" versus "uncovered" diamond stents for the management of distal malignant biliary obstruction | Gut | 2004 | 545 |
| 11 | Application of artificial intelligence using a convolutional neural network for detecting gastric cancer in endoscopic images | Gastric Cancer | 2018 | 539 |
| 12 | Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma | Journal of Hepatology | 2015 | 538 |
| 13 | A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt | Liver International | 2011 | 481 |
| 14 | Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma | Nature Genetics | 2014 | 436 |
| 15 | Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey | Cancer | 2004 | 420 |
| 16 | ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development | Cancer Cell | 2014 | 412 |
| 17 | Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell neoplasms | Gastrointestinal Endoscopy | 2009 | 403 |
| 18 | A Comparison of the Immunochemical Fecal Occult Blood Test and Total Colonoscopy in the Asymptomatic Population | Gastroenterology | 2005 | 396 |
| 19 | A Comparison of the Immunochemical Fecal Occult Blood Test and Total Colonoscopy in the Asymptomatic Population | Gastroenterology | 2005 | 392 |
| 20 | Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling | Cell | 2013 | 384 |
| 21 | Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography | Hepatology | 2009 | 363 |
| 22 | Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling | Nature Medicine | 2002 | 362 |
| 23 | Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma | Clinical Gastroenterology and Hepatology | 2011 | 358 |
| 24 | p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells | Cancer Cell | 2016 | 353 |
| 25 | Hepatocellular carcinoma with extrahepatic metastasis | Cancer | 2011 | 350 |
| 26 | Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases | Clinical Gastroenterology and Hepatology | 2007 | 348 |
| 27 | Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study | Gut | 2005 | 347 |
| 28 | Endoscopic Submucosal Dissection of Esophageal Squamous Cell Neoplasms | Clinical Gastroenterology and Hepatology | 2006 | 339 |
| 29 | Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma | Nature Genetics | 2011 | 332 |
| 30 | Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling | Cancer Cell | 2017 | 332 |
| 31 | Predictors of postoperative stricture after esophageal endoscopic submucosal dissection for superficial squamous cell neoplasms | Endoscopy | 2009 | 317 |
| 32 | Diagnostic outcomes of esophageal cancer by artificial intelligence using convolutional neural networks | Gastrointestinal Endoscopy | 2019 | 314 |
| 33 | Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update | Liver International | 2005 | 313 |
| 34 | Clinical diagnostic criteria of IgG4‐related sclerosing cholangitis 2012 | Journal of Hepato-Biliary-Pancreatic Sciences | 2012 | 309 |
| 35 | Des-?-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma | Cancer | 2001 | 295 |
| 36 | Radiofrequency ablation for hepatocellular carcinoma in so-called high-risk locations | Hepatology | 2006 | 288 |
| 37 | Comparison of Various Submucosal Injection Solutions for Maintaining Mucosal Elevation During Endoscopic Mucosal Resection | Endoscopy | 2004 | 287 |
| 38 | Development of evidence‐based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan | Hepatology Research | 2008 | 279 |
| 39 | NEDD8 recruits E2-ubiquitin to SCF E3 ligase | EMBO Journal | 2001 | 278 |
| 40 | A Mouse Model of Vascular Injury that Induces Rapid Onset of Medial Cell Apoptosis Followed by Reproducible Neointimal Hyperplasia | Journal of Molecular and Cellular Cardiology | 2000 | 277 |
| 41 | Rising incidence of early-onset colorectal cancer — a call to action | Nature Reviews Clinical Oncology | 2021 | 276 |
| 42 | Virulence Factors of Helicobacter pylori Responsible for Gastric Diseases in Mongolian Gerbil | Journal of Experimental Medicine | 2000 | 269 |
| 43 | Interferon Therapy after Tumor Ablation Improves Prognosis in Patients with Hepatocellular Carcinoma Associated with Hepatitis C Virus | Annals of Internal Medicine | 2003 | 264 |
| 44 | The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance | Journal of Clinical Investigation | 2001 | 255 |
| 45 | Successful outcomes of a novel endoscopic treatment for GI tumors: endoscopic submucosal dissection with a mixture of high-molecular-weight hyaluronic acid, glycerin, and sugar | Gastrointestinal Endoscopy | 2006 | 248 |
| 46 | Long-term prognosis of autoimmune pancreatitis with and without corticosteroid treatment | Gut | 2007 | 248 |
| 47 | Combination therapy of intraarterial 5-fluorouracil and systemic interferon-alpha for advanced hepatocellular carcinoma with portal venous invasion | Cancer | 2006 | 244 |
| 48 | Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation | Cancer Science | 2012 | 241 |
| 49 | Proposal of a new prognostic model for hepatocellular carcinoma: an analysis of 403 patients | Gut | 2005 | 237 |
| 50 | Risk assessment for delayed hemorrhagic complication of colonic polypectomy: polyp-related factors and patient-related factors | Gastrointestinal Endoscopy | 2006 | 233 |
