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Top Articles

#TitleJournalYearCitations
1Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 studyBlood2017418
2Anti‐high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in ratsFASEB Journal2007335
3Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ ActivationHypertension2009176
4Sarcopenic obesity in aging population: current status and future directions for researchEndocrine2014144
5Efficacy of primary treatment with immunoglobulin plus ciclosporin for prevention of coronary artery abnormalities in patients with Kawasaki disease predicted to be at increased risk of non-response to intravenous immunoglobulin (KAICA): a randomised controlled, open-label, blinded-endpoints, phase 3 trialLancet, The2019142
6Usefulness of the Kyoto criteria as expanded selection criteria for liver transplantation for hepatocellular carcinomaSurgery2013134
7Etiology of liver cirrhosis in Japan: a nationwide surveyJournal of Gastroenterology2010130
8HLA Class I Binding of HBZ Determines Outcome in HTLV-1 InfectionPLoS Pathogens2010127
9Safety and persistence of WT1-specific T-cell receptor gene−transduced lymphocytes in patients with AML and MDSBlood2017127
10Clinical Interaction between Brain and Kidney in Small Vessel DiseaseCardiology Research and Practice2011125
11Telmisartan prevented cognitive decline partly due to PPAR-γ activationBiochemical and Biophysical Research Communications2008124
12Nocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS)Diabetologia2010114
13Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte SocietyJournal of Allergy and Clinical Immunology: in Practice2018112
14Reinforce the antitumor activity of CD8+ T cells via glutamine restrictionCancer Science2018109
15Neurovascular Coupling in Cognitive Impairment Associated With Diabetes MellitusCirculation Journal2011107
16A Highly Photostable Near‐Infrared Labeling Agent Based on a Phospha‐rhodamine for Long‐Term and Deep ImagingAngewandte Chemie - International Edition2018107
17Antibodies to CD11b, CD68, and lectin label neutrophils rather than microglia in traumatic and ischemic brain lesionsJournal of Neuroscience Research2007106
18Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescenceCardiovascular Research200795
19Percutaneous ultrasound-guided radiofrequency ablation of hepatocellular carcinoma with artificially induced pleural effusion and ascitesJournal of Gastroenterology200795
20Peroxisome Proliferator-Activated Receptor-γ Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic MiceHypertension201291
21Phagocytic elimination of synapses by microglia during sleepGlia202088
22Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T CellsJournal of Immunology200887
23Mental health among young adult survivors of childhood cancer and their siblings including posttraumatic growthJournal of Cancer Survivorship201085
24Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiationNature Communications201585
25The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasisNature Communications201482
26Raising concerns about the Sepsis-3 definitionsWorld Journal of Emergency Surgery201881
27Regulation of angiotensin II receptors beyond the classical pathwayClinical Science201279
28Signaling mechanisms of angiotensin II in regulating vascular senescenceAgeing Research Reviews200978
29Accumulation of Macrophage-Like Cells Expressing NG2 Proteoglycan and Iba1 in Ischemic Core of Rat Brain after Transient Middle Cerebral Artery OcclusionJournal of Cerebral Blood Flow and Metabolism200876
30Emerging Concepts of Regulation of Angiotensin II ReceptorsArteriosclerosis, Thrombosis, and Vascular Biology200774
31Association between cystatin C and inflammation in patients with essential hypertensionClinical and Experimental Nephrology201074
32Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loopNature Communications201673
33Microglial metabolic disturbances and neuroinflammation in cerebral infarctionJournal of Pharmacological Sciences202172
34Possible Role of Angiotensin-Converting Enzyme 2 and Activation of Angiotensin II Type 2 Receptor by Angiotensin-(1–7) in Improvement of Vascular Remodeling by Angiotensin II Type 1 Receptor BlockadeHypertension201471
35Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless micePhytomedicine200968
36Iba1+/NG2+ Macrophage-Like Cells Expressing a Variety of Neuroprotective Factors Ameliorate Ischemic Damage of the BrainJournal of Cerebral Blood Flow and Metabolism201068
37Dietary intake of saturated fatty acids and incident stroke and coronary heart disease in Japanese communities: the JPHC StudyEuropean Heart Journal201366
38Comparison of breast cancer detection by diffusion-weighted magnetic resonance imaging and mammographyRadiation Medicine200764
39TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure MaintenanceCell Metabolism201164
40Direct Angiotensin II Type 2 Receptor Stimulation Ameliorates Insulin Resistance in Type 2 Diabetes Mice with PPARγ ActivationPLoS ONE201264
41Span 80 vesicles have a more fluid, flexible and “wet” surface than phospholipid liposomesColloids and Surfaces B: Biointerfaces201161
42Deficiency of angiotensin-converting enzyme 2 causes deterioration of cognitive functionNpj Aging and Mechanisms of Disease201660
43Nonalcoholic Steatohepatitis in Donors for Living Donor Liver TransplantationTransplantation200759
44Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndromeCardiovascular Diabetology201258
45Frequency and Clinical Characteristics of Early-Onset Dementia in Consecutive Patients in a Memory ClinicDementia and Geriatric Cognitive Disorders200756
46Quantification of the myocardial area at risk using coronary CT angiography and Voronoi algorithm-based myocardial segmentationEuropean Radiology201556
47Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damageBritish Journal of Pharmacology201155
48Activated microglia in a rat stroke model express NG2 proteoglycan in peri‐infarct tissue through the involvement of TGF‐β1Glia201455
49Systemic Glucoregulation by Glucose-Sensing Neurons in the Ventromedial Hypothalamic Nucleus (VMH)Journal of the Endocrine Society201755
50Administration of bovine casein-derived peptide prevents cognitive decline in Alzheimer disease model micePLoS ONE201755