| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Exon-intron circular RNAs regulate transcription in the nucleus | Nature Structural and Molecular Biology | 2015 | 2,330 |
| 3 | Functional exhaustion of antiviral lymphocytes in COVID-19 patients | Cellular and Molecular Immunology | 2020 | 1,450 |
| 4 | Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery | Journal of the American Chemical Society | 2011 | 1,063 |
| 5 | Ultrathin Black Phosphorus Nanosheets for Efficient Singlet Oxygen Generation | Journal of the American Chemical Society | 2015 | 891 |
| 6 | Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts | Stem Cell Reports | 2014 | 854 |
| 7 | Liver: An organ with predominant innate immunity | Hepatology | 2008 | 794 |
| 8 | Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs | Nature Communications | 2014 | 772 |
| 9 | Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells | ACS Nano | 2011 | 722 |
| 10 | In Vitro and In Vivo Near‐Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles | Advanced Materials | 2012 | 684 |
| 11 | Glucose–TOR signalling reprograms the transcriptome and activates meristems | Nature | 2013 | 649 |
| 12 | Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains | Nature Communications | 2017 | 649 |
| 13 | CSS-Palm 2.0: an updated software for palmitoylation sites prediction | Protein Engineering, Design and Selection | 2008 | 511 |
| 14 | Single‐Layered Graphitic‐C3N4 Quantum Dots for Two‐Photon Fluorescence Imaging of Cellular Nucleus | Advanced Materials | 2014 | 501 |
| 15 | Liver-resident NK cells confer adaptive immunity in skin-contact inflammation | Journal of Clinical Investigation | 2013 | 470 |
| 16 | Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor | Advanced Materials | 2012 | 461 |
| 17 | A Tumor‐Acidity‐Activated Charge‐Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral‐Cell Uptake and Drug Delivery | Angewandte Chemie - International Edition | 2010 | 459 |
| 18 | Cholesterol metabolism and homeostasis in the brain | Protein and Cell | 2015 | 458 |
| 19 | Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity | Nature Communications | 2018 | 448 |
| 20 | Red Emission B, N, S-co-Doped Carbon Dots for Colorimetric and Fluorescent Dual Mode Detection of Fe3+ Ions in Complex Biological Fluids and Living Cells | ACS Applied Materials & Interfaces | 2017 | 437 |
| 21 | Bridging Biological and Artificial Neural Networks with Emerging Neuromorphic Devices: Fundamentals, Progress, and Challenges | Advanced Materials | 2019 | 418 |
| 22 | Polyethylene Glycol and Polyethylenimine Dual‐Functionalized Nano‐Graphene Oxide for Photothermally Enhanced Gene Delivery | Small | 2013 | 378 |
| 23 | Cryo-EM structure of the mature dengue virus at 3.5-Å resolution | Nature Structural and Molecular Biology | 2013 | 372 |
| 24 | Regulation of the pentose phosphate pathway in cancer | Protein and Cell | 2014 | 363 |
| 25 | Sequentially Responsive Shell‐Stacked Nanoparticles for Deep Penetration into Solid Tumors | Advanced Materials | 2017 | 360 |
| 26 | Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor | Nature Communications | 2020 | 339 |
| 27 | Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis | Journal of Biological Chemistry | 2003 | 329 |
| 28 | Activated Expression of anArabidopsisHD-START Protein Confers Drought Tolerance with Improved Root System and Reduced Stomatal Density | Plant Cell | 2008 | 329 |
| 29 | The lncRNA Neat1 promotes activation of inflammasomes in macrophages | Nature Communications | 2019 | 323 |
| 30 | Long Non-coding RNAs in the Cytoplasm | Genomics, Proteomics and Bioinformatics | 2016 | 300 |
| 31 | A Mesoporous Nanoenzyme Derived from Metal–Organic Frameworks with Endogenous Oxygen Generation to Alleviate Tumor Hypoxia for Significantly Enhanced Photodynamic Therapy | Advanced Materials | 2019 | 282 |
| 32 | YTH Domain: A Family of N 6 -methyladenosine (m 6 A) Readers | Genomics, Proteomics and Bioinformatics | 2018 | 277 |
| 33 | Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery | ACS Nano | 2012 | 265 |
| 34 | Computational Redesign of a PETase for Plastic Biodegradation under Ambient Condition by the GRAPE Strategy | ACS Catalysis | 2021 | 263 |
| 35 | Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery | Advanced Materials | 2012 | 256 |
| 36 | Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy | ACS Nano | 2019 | 251 |
| 37 | MicroRNA-224 Is Involved in Transforming Growth Factor-β-Mediated Mouse Granulosa Cell Proliferation and Granulosa Cell Function by Targeting Smad4 | Molecular Endocrinology | 2010 | 249 |
| 38 | Ratiometric Detection of Intracellular Lysine and pH with One-Pot Synthesized Dual Emissive Carbon Dots | Analytical Chemistry | 2017 | 247 |
| 39 | Controllable synthesis of dual-MOFs nanostructures for pH-responsive artemisinin delivery, magnetic resonance and optical dual-model imaging-guided chemo/photothermal combinational cancer therapy | Biomaterials | 2016 | 245 |
| 40 | Ultrafast Two-Photon Imaging of a High-Gain Voltage Indicator in Awake Behaving Mice | Cell | 2019 | 242 |
| 41 | Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect | Biochimica Et Biophysica Acta: Reviews on Cancer | 2018 | 241 |
| 42 | GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability | Nature Cell Biology | 2018 | 239 |
| 43 | Natural killer cells in liver disease | Hepatology | 2013 | 237 |
| 44 | Arabidopsis ERF109 mediates cross-talk between jasmonic acid and auxin biosynthesis during lateral root formation | Nature Communications | 2014 | 237 |
| 45 | Rapid whole brain imaging of neural activity in freely behaving larval zebrafish (Danio rerio) | ELife | 2017 | 237 |
| 46 | Spatiotemporal manipulation of auxin biosynthesis in cotton ovule epidermal cells enhances fiber yield and quality | Nature Biotechnology | 2011 | 236 |
| 47 | Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation | Biochemical and Biophysical Research Communications | 2002 | 235 |
| 48 | HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production | Journal of Hepatology | 2017 | 232 |
| 49 | Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery | Biomaterials | 2008 | 227 |
| 50 | Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy | Journal of Controlled Release | 2011 | 223 |
