| # | Title | Journal | Year | Citations |
|---|
| 1 | General Cardiovascular Risk Profile for Use in Primary Care | Circulation | 2008 | 5,601 |
| 2 | Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond | Statistics in Medicine | 2008 | 5,331 |
| 3 | Assessing the Performance of Prediction Models | Epidemiology | 2010 | 3,387 |
| 4 | Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers | Statistics in Medicine | 2011 | 1,989 |
| 5 | Validation of the Framingham Coronary Heart Disease Prediction Scores | JAMA - Journal of the American Medical Association | 2001 | 1,798 |
| 6 | Comments on ‘Integrated discrimination and net reclassification improvements—Practical advice’ | Statistics in Medicine | 2008 | 1,299 |
| 7 | OverallC as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation | Statistics in Medicine | 2004 | 1,264 |
| 8 | Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial | Lancet, The | 2018 | 1,179 |
| 9 | On the C‐statistics for evaluating overall adequacy of risk prediction procedures with censored survival data | Statistics in Medicine | 2011 | 972 |
| 10 | DGM: A deep learning algorithm for solving partial differential equations | Journal of Computational Physics | 2018 | 966 |
| 11 | Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study | Lancet, The | 2009 | 883 |
| 12 | The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination | American Journal of Epidemiology | 2007 | 752 |
| 13 | Electroencephalogram signatures of loss and recovery of consciousness from propofol | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 679 |
| 14 | Application of New Cholesterol Guidelines to a Population-Based Sample | New England Journal of Medicine | 2014 | 571 |
| 15 | The influence of gender and age on disability following ischemic stroke: the Framingham study | Journal of Stroke and Cerebrovascular Diseases | 2003 | 566 |
| 16 | Atrial Fibrillation Begets Heart Failure and Vice Versa | Circulation | 2016 | 561 |
| 17 | Tropical forests are a net carbon source based on aboveground measurements of gain and loss | Science | 2017 | 539 |
| 18 | Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection | Nature Immunology | 2022 | 486 |
| 19 | Age-Related Changes in 1/fNeural Electrophysiological Noise | Journal of Neuroscience | 2015 | 479 |
| 20 | Physical distancing interventions and incidence of coronavirus disease 2019: natural experiment in 149 countries | BMJ, The | 2020 | 427 |
| 21 | Epilepsy as a Disorder of Cortical Network Organization | Neuroscientist | 2012 | 426 |
| 22 | Rhizosphere processes are quantitatively important components of terrestrial carbon and nutrient cycles | Global Change Biology | 2015 | 424 |
| 23 | Genome-wide association study of PR interval | Nature Genetics | 2010 | 400 |
| 24 | LDL particle number and risk of future cardiovascular disease in the Framingham Offspring Study—Implications for LDL management | Journal of Clinical Lipidology | 2007 | 365 |
| 25 | Overweight, Obesity, and the Development of Stage 3 CKD: The Framingham Heart Study | American Journal of Kidney Diseases | 2008 | 321 |
| 26 | Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data | Prenatal Diagnosis | 2002 | 318 |
| 27 | Beyond the Connectome: The Dynome | Neuron | 2014 | 315 |
| 28 | Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 313 |
| 29 | A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study | BMC Medical Genetics | 2007 | 289 |
| 30 | Evaluating Discrimination of Risk Prediction Models | JAMA - Journal of the American Medical Association | 2015 | 268 |
| 31 | Striatal origin of the pathologic beta oscillations in Parkinson's disease | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 267 |
| 32 | Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure | Blood | 2016 | 255 |
| 33 | Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models | Statistics in Medicine | 2012 | 250 |
| 34 | A neurophysiological–metabolic model for burst suppression | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 241 |
| 35 | Emergent network topology at seizure onset in humans | Epilepsy Research | 2008 | 233 |
| 36 | Predicting Heart Failure With Preserved and Reduced Ejection Fraction | Circulation: Heart Failure | 2016 | 227 |
| 37 | Coalescence and Fragmentation of Cortical Networks during Focal Seizures | Journal of Neuroscience | 2010 | 225 |
| 38 | Framingham Stroke Risk Profile and Lowered Cognitive Performance | Stroke | 2004 | 223 |
| 39 | Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease | Nature Communications | 2018 | 221 |
| 40 | Marital Status, Marital Strain, and Risk of Coronary Heart Disease or Total Mortality: The Framingham Offspring Study | Psychosomatic Medicine | 2007 | 199 |
| 41 | Association of Oxidative Stress, Insulin Resistance, and Diabetes Risk Phenotypes | Diabetes Care | 2007 | 198 |
| 42 | Stoichiometry constrains microbial response to root exudation- insights from a model and a field experiment in a temperate forest | Biogeosciences | 2013 | 197 |
| 43 | Misuse of DeLong test to compare AUCs for nested models | Statistics in Medicine | 2012 | 192 |
| 44 | Protein Biomarkers of Cardiovascular Disease and Mortality in the Community | Journal of the American Heart Association | 2018 | 188 |
| 45 | Introduction to Hamiltonian Dynamical Systems and the N-Body Problem | Applied Mathematical Sciences (Switzerland) | 2009 | 187 |
| 46 | Neurosystems: brain rhythms and cognitive processing | European Journal of Neuroscience | 2014 | 186 |
| 47 | Wolbachia Enhance Drosophila Stem Cell Proliferation and Target the Germline Stem Cell Niche | Science | 2011 | 183 |
| 48 | Human seizures self-terminate across spatial scales via a critical transition | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 182 |
| 49 | Modeling GABA Alterations in Schizophrenia: A Link Between Impaired Inhibition and Altered Gamma and Beta Range Auditory Entrainment | Journal of Neurophysiology | 2008 | 180 |
| 50 | Systemic Inflammation and COPD | Chest | 2008 | 178 |
