| # | Title | Journal | Year | Citations |
|---|
| 1 | Cancer classification using the Immunoscore: a worldwide task force | Journal of Translational Medicine | 2012 | 676 |
| 2 | G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane | Biochemical and Biophysical Research Communications | 2006 | 313 |
| 3 | Abnormal asymmetries in subcortical brain volume in schizophrenia | Molecular Psychiatry | 2016 | 300 |
| 4 | Directionally tunable and mechanically deformable ferroelectric crystals from rotating polar globular ionic molecules | Nature Chemistry | 2016 | 278 |
| 5 | Japanese Clinical Practice Guideline for Diabetes 2019 | Diabetology International | 2020 | 266 |
| 6 | Second-Harmonic Imaging Microscopy of Normal Human and Keratoconus Cornea | | 2007 | 253 |
| 7 | Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia. Primary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT). | Circulation Journal | 2002 | 243 |
| 8 | A robust automatic crack detection method from noisy concrete surfaces | Machine Vision and Applications | 2011 | 211 |
| 9 | Structural basis of starvation-induced assembly of the autophagy initiation complex | Nature Structural and Molecular Biology | 2014 | 180 |
| 10 | Altered gene expression of histone deacetylases in mood disorder patients | Journal of Psychiatric Research | 2010 | 163 |
| 11 | Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses | Biotechnology for Biofuels | 2015 | 159 |
| 12 | Japanese Clinical Practice Guideline for Diabetes 2019 | Journal of Diabetes Investigation | 2020 | 159 |
| 13 | Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells | Blood | 2005 | 157 |
| 14 | Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosis | World Journal of Urology | 2010 | 156 |
| 15 | Volatile 1-octen-3-ol induces a defensive response in Arabidopsis thaliana | Journal of General Plant Pathology | 2007 | 135 |
| 16 | Stretching Actin Filaments within Cells Enhances their Affinity for the Myosin II Motor Domain | PLoS ONE | 2011 | 135 |
| 17 | Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia and Coronary Heart Disease. Secondary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT). | Circulation Journal | 2002 | 131 |
| 18 | Growth and ethanol fermentation ability on hexose and pentose sugars and glucose effect under various conditions in thermotolerant yeast Kluyveromyces marxianus | Applied Microbiology and Biotechnology | 2011 | 130 |
| 19 | Development of Definitive and Reliable Grading Scales for Meibomian Gland Dysfunction | American Journal of Ophthalmology | 2016 | 118 |
| 20 | An Efficient Method To Depolymerize Polyamide Plastics: A New Use of Ionic Liquids | Organic Letters | 2007 | 117 |
| 21 | Li+ Solvation and Ionic Transport in Lithium Solvate Ionic Liquids Diluted by Molecular Solvents | Journal of Physical Chemistry C | 2016 | 114 |
| 22 | Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation | PLoS ONE | 2012 | 108 |
| 23 | Direct fungicidal activities of C6-aldehydes are important constituents for defense responses in Arabidopsis against Botrytis cinerea | Phytochemistry | 2008 | 105 |
| 24 | Evaluation of the Long-Term Efficacy and Safety of Infliximab Treatment for Uveitis in Behçet's Disease | Ophthalmology | 2014 | 103 |
| 25 | Hydrothermal preparation of tailored hydroxyapatite | Journal of Materials Science | 2006 | 100 |
| 26 | Prediction of postoperative delirium after abdominal surgery in the elderly | Journal of Anesthesia | 2009 | 98 |
| 27 | Effects of Stent Structure on Stent Flexibility Measurements | Annals of Biomedical Engineering | 2005 | 89 |
| 28 | Protocol and standard operating procedures for common use in a worldwide multicenter study on reference values | Clinical Chemistry and Laboratory Medicine | 2013 | 89 |
| 29 | Usefulness of Sonazoid contrast-enhanced ultrasonography for hepatocellular carcinoma: comparison with pathological diagnosis and superparamagnetic iron oxide magnetic resonance images | Journal of Gastroenterology | 2009 | 85 |
| 30 | Li+ Local Structure in Hydrofluoroether Diluted Li-Glyme Solvate Ionic Liquid | Journal of Physical Chemistry B | 2016 | 81 |
| 31 | Selection and characterization of a newly isolated thermotolerant Pichia kudriavzevii strain for ethanol production at high temperature from cassava starch hydrolysate | Antonie Van Leeuwenhoek | 2013 | 79 |
| 32 | Nonequilibrium Energetics of Molecular Motor Kinesin | Physical Review Letters | 2018 | 78 |
| 33 | Inhibition of protein phosphatase 1 by inhibitor‐2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy | FASEB Journal | 2006 | 77 |
| 34 | Cytometric Analysis of DNA Damage: Phosphorylation of Histone H2AX as a Marker of DNA Double-Strand Breaks (DSBs) | Methods in Molecular Biology | 2009 | 77 |
| 35 | Sustained Reduction of Serum Cholesterol in Low-Dose 6-Year Simvastatin Treatment With Minimum Side Effects in 51,321 Japanese Hypercholesterolemic Patients. Implication of the J-LIT Study, a Large Scale Nationwide Cohort Study. | Circulation Journal | 2003 | 75 |
| 36 | Application of second harmonic imaging microscopy to assess structural changes in optic nerve head structure ex vivo | Journal of Biomedical Optics | 2007 | 75 |
| 37 | Carotenoid, Tocopherol, and Fatty Acid Biomarkers and Dietary Intake Estimated by Using a Brief Self-Administered Diet History Questionnaire for Older Japanese Children and Adolescents | Journal of Nutritional Science and Vitaminology | 2009 | 74 |
| 38 | Biomarker-based detection of asthma–COPD overlap syndrome in COPD populations | International Journal of COPD | 2015 | 74 |
| 39 | Molecular Strategy for Survival at a Critical High Temperature in Eschierichia coli | PLoS ONE | 2011 | 73 |
| 40 | Texture analysis on 18F-FDG PET/CT images to differentiate malignant and benign bone and soft-tissue lesions | Annals of Nuclear Medicine | 2014 | 73 |
| 41 | ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia | Haematologica | 2016 | 72 |
| 42 | Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture | International Journal of Molecular Sciences | 2018 | 72 |
| 43 | FABP3 Protein Promotes α-Synuclein Oligomerization Associated with 1-Methyl-1,2,3,6-tetrahydropiridine-induced Neurotoxicity | Journal of Biological Chemistry | 2014 | 71 |
| 44 | Beneficial effects of Waon therapy on patients with chronic heart failure: Results of a prospective multicenter study | Journal of Cardiology | 2008 | 70 |
| 45 | A novel pyrene-based two-photon active fluorescent dye efficiently excited and emitting in the ‘tissue optical window (650–1100 nm)’ | Journal of Materials Chemistry B | 2015 | 70 |
| 46 | Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6 | Blood | 2002 | 69 |
| 47 | Actin-based propulsive forces and myosin-II-based contractile forces in migratingDictyosteliumcells | Journal of Cell Science | 2008 | 69 |
| 48 | Roles of reactive oxygen species in the corpus luteum | Animal Science Journal | 2006 | 68 |
| 49 | The Histone Chaperone Facilitates Chromatin Transcription (FACT) Protein Maintains Normal Replication Fork Rates | Journal of Biological Chemistry | 2011 | 68 |
| 50 | Effect of zinc on liver cirrhosis with hyperammonemia: A preliminary randomized, placebo-controlled double-blind trial | Nutrition | 2014 | 67 |
