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Biotechnology Process Engineering Center
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top-articles
Biotechnology Process Engineering Center
91
(top 1%)
papers
5.3K
(top 1%)
citations
33
(top 1%)
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-index
68
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94
all documents
5.5K
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1.1K
citing journals
Top Articles
#
Title
Journal
Year
Citations
1
Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems
Biotechnology and Bioengineering
2002
321
2
Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds
Differentiation
2003
310
3
Specific aggregation of partially folded polypeptide chains: The molecular basis of inclusion body composition
Nature Biotechnology
1996
301
4
Effects of substratum morphology on cell physiology
Biotechnology and Bioengineering
1994
282
5
Functional Behavior of Primary Rat Liver Cells in a Three-Dimensional Perfused Microarray Bioreactor
Tissue Engineering
2002
221
6
Modeling of Isotope Distributions and Intracellular Fluxes in Metabolic Networks Using Atom Mapping Matrixes
Biotechnology Progress
1994
179
7
Intracellular flux analysis in hybridomas using mass balances and in vitro13C nmr
Biotechnology and Bioengineering
1995
174
8
Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes
Gene Therapy
2005
173
9
Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies
Biotechnology and Bioengineering
1994
161
10
Improvement of interferon-γ sialylation in Chinese hamster ovary cell culture by feeding ofN-acetylmannosamine
Biotechnology and Bioengineering
1998
139
11
Polyethylene Glycol Enhanced Protein Refolding
Nature Biotechnology
1992
137
12
Metabolic flux analysis of hybridoma continuous culture steady state multiplicity
1999
133
13
A liquid emulsion membrane process for the separation of amino acids
Biotechnology and Bioengineering
1990
129
14
Stoichiometric analysis of animal cell growth and its application in medium design
Biotechnology and Bioengineering
1994
114
15
Model of oxygen transport limitations in hollow fiber bioreactors
Biotechnology and Bioengineering
1991
113
16
Metabolic effects on recombinant interferon-? glycosylation in continuous culture of Chinese hamster ovary cells
1999
111
17
Quantitative description of ultrafiltration in a rotating filtration device
AICHE Journal
1991
102
18
Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas
Applied Microbiology and Biotechnology
1995
96
19
Design and evalution of control strategies for high cell density fermentations
Biotechnology and Bioengineering
1992
94
20
Cosolvent Assisted Protein Refolding
Nature Biotechnology
1990
87
21
Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation
Biotechnology and Bioengineering
2000
87
22
High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor
2000
86
23
Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6
Stem Cells
2002
85
24
α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development
Journal of Cell Biology
2007
84
25
Polymerization mechanism of polypeptide chain aggregation
1997
83
26
Multimeric intermediates in the pathway to the aggregated inclusion body state for P22 tailspike polypeptide chains
Protein Science
1995
81
27
Effects of Oxygen on Recombinant Protein Expression
Biotechnology Progress
1998
73
28
Mammalian cell and protein distributions in ultrafiltration hollow fiber bioreactors
Biotechnology and Bioengineering
1990
72
29
Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK)
Biotechnology and Bioengineering
2003
64
30
Material balance studies on animal cell metabolism using a stoichiometrically based reaction network
2000
63
31
Water transport mechanism in liquid emulsion membrane process for the separation of amino acids
Journal of Membrane Science
1990
62
32
Effects of paddle impeller geometry on power input and mass transfer in small-scale animal cell culture vessels
Biotechnology and Bioengineering
1989
60
33
A fiber-bed bioreactor for anchorage-dependent animal cell cultures: Part I. Bioreactor design and operations
Biotechnology and Bioengineering
1991
59
34
Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector
New Biotechnology
2001
56
35
Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network
2000
55
36
Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions
1997
54
37
Rapid Monitoring of Site-Specific Glycosylation Microheterogeneity of Recombinant Human Interferon-γ
Analytical Chemistry
1996
51
38
Quantitative analysis and process monitoring of site-specific glycosylation microheterogeneity in recombinant human interferon-γ from Chinese hamster ovary cell culture by hydrophilic interaction chromatography
Biomedical Applications
1998
47
39
Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis
Biotechnology and Bioengineering
2003
45
40
High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor
1996
45
41
Nutrient and metabolite gradients in mammalian cell hollow fiber bioreactors
Canadian Journal of Chemical Engineering
1991
36
42
Site- and branch-specific sialylation of recombinant human interferon-γ in Chinese hamster ovary cell culture
1997
36
43
Artificial intelligence in the development and design of biochemical processes
Trends in Biotechnology
1986
35
44
Influence of Primatone RL supplementation on sialylation of recombinant human interferon-γ produced by Chinese hamster ovary cell culture using serum-free media
1997
35
45
Determination of monoclonal antibody production in cell culture using novel microfluidic and traditional assays
Electrophoresis
2002
32
46
In-situ removal of ammonium and lactate through electrical means for hybridoma cultures
Biotechnology and Bioengineering
1995
30
47
Transient association of the first intermediate during the refolding of bovine carbonic anhydrase B
Biotechnology Progress
1992
29
48
Improvement of interferon-gamma sialylation in Chinese hamster ovary cell culture by feeding of N-acetylmannosamine
Biotechnology and Bioengineering
1998
29
49
Immobilized mammalian cell cultivation in hollow fiber bioreactors
Biotechnology Advances
1990
28
50
Recovery of Antigens From Immunoadsorbents Using High Pressure
Nature Biotechnology
1989
27
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