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#	Title	Journal	Year	Citations
1	Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems	Biotechnology and Bioengineering	2002	321
2	Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds	Differentiation	2003	310
3	Specific aggregation of partially folded polypeptide chains: The molecular basis of inclusion body composition	Nature Biotechnology	1996	301
4	Effects of substratum morphology on cell physiology	Biotechnology and Bioengineering	1994	282
5	Functional Behavior of Primary Rat Liver Cells in a Three-Dimensional Perfused Microarray Bioreactor	Tissue Engineering	2002	221
6	Modeling of Isotope Distributions and Intracellular Fluxes in Metabolic Networks Using Atom Mapping Matrixes	Biotechnology Progress	1994	179
7	Intracellular flux analysis in hybridomas using mass balances and in vitro13C nmr	Biotechnology and Bioengineering	1995	174
8	Quantitative comparison of polyethylenimine formulations and adenoviral vectors in terms of intracellular gene delivery processes	Gene Therapy	2005	173
9	Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies	Biotechnology and Bioengineering	1994	161
10	Improvement of interferon-γ sialylation in Chinese hamster ovary cell culture by feeding ofN-acetylmannosamine	Biotechnology and Bioengineering	1998	139
11	Polyethylene Glycol Enhanced Protein Refolding	Nature Biotechnology	1992	137
12	Metabolic flux analysis of hybridoma continuous culture steady state multiplicity		1999	133
13	A liquid emulsion membrane process for the separation of amino acids	Biotechnology and Bioengineering	1990	129
14	Stoichiometric analysis of animal cell growth and its application in medium design	Biotechnology and Bioengineering	1994	114
15	Model of oxygen transport limitations in hollow fiber bioreactors	Biotechnology and Bioengineering	1991	113
16	Metabolic effects on recombinant interferon-? glycosylation in continuous culture of Chinese hamster ovary cells		1999	111
17	Quantitative description of ultrafiltration in a rotating filtration device	AICHE Journal	1991	102
18	Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas	Applied Microbiology and Biotechnology	1995	96
19	Design and evalution of control strategies for high cell density fermentations	Biotechnology and Bioengineering	1992	94
20	Cosolvent Assisted Protein Refolding	Nature Biotechnology	1990	87
21	Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation	Biotechnology and Bioengineering	2000	87
22	High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor		2000	86
23	Ligand/Receptor Signaling Threshold (LIST) Model Accounts for gp130-Mediated Embryonic Stem Cell Self-Renewal Responses to LIF and HIL-6	Stem Cells	2002	85
24	α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development	Journal of Cell Biology	2007	84
25	Polymerization mechanism of polypeptide chain aggregation		1997	83
26	Multimeric intermediates in the pathway to the aggregated inclusion body state for P22 tailspike polypeptide chains	Protein Science	1995	81
27	Effects of Oxygen on Recombinant Protein Expression	Biotechnology Progress	1998	73
28	Mammalian cell and protein distributions in ultrafiltration hollow fiber bioreactors	Biotechnology and Bioengineering	1990	72
29	Clonal expansion of adult rat hepatic stem cell lines by suppression of asymmetric cell kinetics (SACK)	Biotechnology and Bioengineering	2003	64
30	Material balance studies on animal cell metabolism using a stoichiometrically based reaction network		2000	63
31	Water transport mechanism in liquid emulsion membrane process for the separation of amino acids	Journal of Membrane Science	1990	62
32	Effects of paddle impeller geometry on power input and mass transfer in small-scale animal cell culture vessels	Biotechnology and Bioengineering	1989	60
33	A fiber-bed bioreactor for anchorage-dependent animal cell cultures: Part I. Bioreactor design and operations	Biotechnology and Bioengineering	1991	59
34	Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector	New Biotechnology	2001	56
35	Energy metabolism and ATP balance in animal cell cultivation using a stoichiometrically based reaction network		2000	55
36	Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions		1997	54
37	Rapid Monitoring of Site-Specific Glycosylation Microheterogeneity of Recombinant Human Interferon-γ	Analytical Chemistry	1996	51
38	Quantitative analysis and process monitoring of site-specific glycosylation microheterogeneity in recombinant human interferon-γ from Chinese hamster ovary cell culture by hydrophilic interaction chromatography	Biomedical Applications	1998	47
39	Supplementation-dependent differences in the rates of embryonic stem cell self-renewal, differentiation, and apoptosis	Biotechnology and Bioengineering	2003	45
40	High cell density and high monoclonal antibody production through medium design and rational control in a bioreactor		1996	45
41	Nutrient and metabolite gradients in mammalian cell hollow fiber bioreactors	Canadian Journal of Chemical Engineering	1991	36
42	Site- and branch-specific sialylation of recombinant human interferon-γ in Chinese hamster ovary cell culture		1997	36
43	Artificial intelligence in the development and design of biochemical processes	Trends in Biotechnology	1986	35
44	Influence of Primatone RL supplementation on sialylation of recombinant human interferon-γ produced by Chinese hamster ovary cell culture using serum-free media		1997	35
45	Determination of monoclonal antibody production in cell culture using novel microfluidic and traditional assays	Electrophoresis	2002	32
46	In-situ removal of ammonium and lactate through electrical means for hybridoma cultures	Biotechnology and Bioengineering	1995	30
47	Transient association of the first intermediate during the refolding of bovine carbonic anhydrase B	Biotechnology Progress	1992	29
48	Improvement of interferon-gamma sialylation in Chinese hamster ovary cell culture by feeding of N-acetylmannosamine	Biotechnology and Bioengineering	1998	29
49	Immobilized mammalian cell cultivation in hollow fiber bioreactors	Biotechnology Advances	1990	28
50	Recovery of Antigens From Immunoadsorbents Using High Pressure	Nature Biotechnology	1989	27

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