| # | Title | Journal | Year | Citations |
|---|
| 1 | Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily | Pharmacogenetics and Genomics | 2005 | 708 |
| 2 | Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics | Nature Communications | 2017 | 507 |
| 3 | Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease | Journal of Neuropathology and Experimental Neurology | 2009 | 392 |
| 4 | Pharmacogenomics of human UDP-glucuronosyltransferase enzymes | Pharmacogenomics Journal | 2003 | 386 |
| 5 | Common Human UGT1A Polymorphisms and the Altered Metabolism of Irinotecan Active Metabolite 7-Ethyl-10-hydroxycamptothecin (SN-38) | Molecular Pharmacology | 2002 | 338 |
| 6 | High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model | Neurobiology of Aging | 2010 | 241 |
| 7 | Hypertriglyceridemic waist: A useful screening phenotype in preventive cardiology? | Canadian Journal of Cardiology | 2007 | 230 |
| 8 | Leptin Gene Epigenetic Adaptation to Impaired Glucose Metabolism During Pregnancy | Diabetes Care | 2010 | 218 |
| 9 | Emerging understanding of the protein corona at the nano-bio interfaces | Nano Today | 2016 | 205 |
| 10 | Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice | Gut | 2019 | 200 |
| 11 | Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer’s Disease | Cell Stem Cell | 2015 | 192 |
| 12 | Identification of common polymorphisms in the promoter of the UGT1A9 gene | Pharmacogenetics and Genomics | 2004 | 191 |
| 13 | Increased adenosine A2A receptors in the brain of Parkinson's disease patients with dyskinesias | Brain | 2004 | 189 |
| 14 | Placental Adiponectin Gene DNA Methylation Levels Are Associated With Mothers’ Blood Glucose Concentration | Diabetes | 2012 | 188 |
| 15 | Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and Flavopiridol Anticancer Drugs | Journal of Pharmacology and Experimental Therapeutics | 2003 | 185 |
| 16 | Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation | Cell Metabolism | 2020 | 185 |
| 17 | Block of the Rapid Component of the Delayed Rectifier Potassium Current by the Prokinetic Agent Cisapride Underlies Drug-Related Lengthening of the QT Interval | Circulation | 1998 | 173 |
| 18 | Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents | Carcinogenesis | 1998 | 171 |
| 19 | Neuroprotective properties of 17β‐estradiol, progesterone, and raloxifene in MPTP C57Bl/6 mice | Synapse | 2001 | 170 |
| 20 | Defective dentate nucleus GABA receptors in essential tremor | Brain | 2012 | 163 |
| 21 | Contribution of estrogen receptors alpha and beta to the effects of estradiol in the brain | Journal of Steroid Biochemistry and Molecular Biology | 2008 | 158 |
| 22 | The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers | Clinical Pharmacology and Therapeutics | 2007 | 146 |
| 23 | Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors | Brain Research Reviews | 2001 | 144 |
| 24 | Visceral obesity and the heart | International Journal of Biochemistry and Cell Biology | 2008 | 142 |
| 25 | Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398 | Cancer Research | 1998 | 141 |
| 26 | Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications | Progress in Neurobiology | 2007 | 136 |
| 27 | Desire for euthanasia or physician-assisted suicide in palliative cancer care. | Health Psychology | 2007 | 136 |
| 28 | Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine | Drug Metabolism and Disposition | 2009 | 134 |
| 29 | Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity | Clinical Pharmacology and Therapeutics | 2000 | 130 |
| 30 | UGT genomic diversity: beyond gene duplication | Drug Metabolism Reviews | 2010 | 124 |
| 31 | Metabolomic profiling of 17 bile acids in serum from patients with primary biliary cirrhosis and primary sclerosing cholangitis: A pilot study | Digestive and Liver Disease | 2012 | 118 |
| 32 | Tissue-specific, Inducible, and Hormonal Control of the Human UDP-Glucuronosyltransferase-1 (UGT1) Locus | Journal of Biological Chemistry | 2005 | 113 |
| 33 | Elevated levels of ΔFosB and RGS9 in striatum in Parkinson’s disease | Biological Psychiatry | 2001 | 107 |
| 34 | Associations of outdoor fine particulate air pollution and cardiovascular disease in 157 436 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study | Lancet Planetary Health, The | 2020 | 106 |
| 35 | Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver | Hepatology | 2006 | 105 |
| 36 | Changes of GABA receptors and dopamine turnover in the postmortem brains of parkinsonians with levodopa-induced motor complications | Movement Disorders | 2003 | 102 |
| 37 | Reduced Incidence of Vagally Induced Atrial Fibrillation and Expression Levels of Connexins by n-3 Polyunsaturated Fatty Acids in Dogs | Journal of the American College of Cardiology | 2007 | 102 |
| 38 | Nonsteroidal anti‐inflammatory drug use and the risk of cognitive impairment and Alzheimer's disease | Alzheimer's and Dementia | 2012 | 102 |
| 39 | Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates | Pharmacogenetics and Genomics | 2000 | 101 |
| 40 | Molecular links between aging and adipose tissue | International Journal of Obesity | 2005 | 100 |
| 41 | Characterization of Common UGT1A8, UGT1A9, and UGT2B7 Variants with Different Capacities to Inactivate Mutagenic 4-Hydroxylated Metabolites of Estradiol and Estrone | Cancer Research | 2006 | 100 |
| 42 | Differential Regulation of Striatal Preproenkephalin and Preprotachykinin mRNA Levels in MPTP-Lesioned Monkeys Chronically Treated with Dopamine D1 or D2 Receptor Agonists | Journal of Neurochemistry | 1999 | 96 |
| 43 | The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in l-Dopa-treated parkinsonian monkeys | Parkinsonism and Related Disorders | 2011 | 96 |
| 44 | Anti-polyethylene glycol antibodies alter the protein corona deposited on nanoparticles and the physiological pathways regulating their fate in vivo | Journal of Controlled Release | 2018 | 96 |
| 45 | ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier | Journal of Alzheimer's Disease | 2012 | 95 |
| 46 | Serotonin Toxicity Associated with Concomitant Use of Linezolid | Annals of Pharmacotherapy | 2005 | 94 |
| 47 | Low doses of sarizotan reduce dyskinesias and maintain antiparkinsonian efficacy of l-Dopa in parkinsonian monkeys | Parkinsonism and Related Disorders | 2009 | 94 |
| 48 | Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11) | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 94 |
| 49 | Regulation of the UGT1A1 bilirubin-conjugating pathway: Role of a new splicing event at the UGT1A locus | Hepatology | 2007 | 90 |
| 50 | Rhythmic pattern in pain and their chronotherapy | Advanced Drug Delivery Reviews | 2007 | 88 |
