| # | Title | Journal | Year | Citations |
|---|
| 1 | Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review | Gastroenterology | 2012 | 4,013 |
| 2 | Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial | Gastroenterology | 2007 | 1,986 |
| 3 | New ICD-10 version of the Charlson comorbidity index predicted in-hospital mortality | Journal of Clinical Epidemiology | 2004 | 1,818 |
| 4 | Chronic kidney disease and cardiovascular risk: epidemiology, mechanisms, and prevention | Lancet, The | 2013 | 1,613 |
| 5 | Physician wellness: a missing quality indicator | Lancet, The | 2009 | 1,202 |
| 6 | Sleep monitoring in the intensive care unit: comparison of nurse assessment, actigraphy and polysomnography | Intensive Care Medicine | 2008 | 1,130 |
| 7 | Methotrexate for the Treatment of Crohn's Disease | New England Journal of Medicine | 1995 | 920 |
| 8 | 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary] | Cmaj | 2007 | 878 |
| 9 | Relation Between Kidney Function, Proteinuria, and Adverse Outcomes | JAMA - Journal of the American Medical Association | 2010 | 876 |
| 10 | The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response | Nature | 2008 | 838 |
| 11 | Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer | Gut and Liver | 2012 | 801 |
| 12 | Understanding and Preventing the Global Increase of Inflammatory Bowel Disease | Gastroenterology | 2017 | 777 |
| 13 | Adipokines: molecular links between obesity and atheroslcerosis | American Journal of Physiology - Heart and Circulatory Physiology | 2005 | 752 |
| 14 | Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis | Journal of Hepatology | 2017 | 734 |
| 15 | Gallbladder cancer: epidemiology and outcome | Clinical Epidemiology | 2014 | 679 |
| 16 | Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies | Gastroenterology | 2013 | 670 |
| 17 | Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy | Lancet, The | 2017 | 662 |
| 18 | The inflammasome: a danger sensing complex triggering innate immunity | Current Opinion in Immunology | 2007 | 640 |
| 19 | Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial | Lancet, The | 2017 | 633 |
| 20 | The safety of vedolizumab for ulcerative colitis and Crohn's disease | Gut | 2017 | 630 |
| 21 | Estimated glomerular filtration rate and albuminuria for prediction of cardiovascular outcomes: a collaborative meta-analysis of individual participant data | Lancet Diabetes and Endocrinology,the | 2015 | 604 |
| 22 | Effect of Frequent Nocturnal Hemodialysis vs Conventional Hemodialysis on Left Ventricular Mass and Quality of Life | JAMA - Journal of the American Medical Association | 2007 | 603 |
| 23 | Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study | Lancet, The | 2012 | 601 |
| 24 | Drug treatments for covid-19: living systematic review and network meta-analysis | BMJ, The | 2020 | 592 |
| 25 | Natalizumab for the Treatment of Active Crohn’s Disease: Results of the ENCORE Trial | Gastroenterology | 2007 | 586 |
| 26 | Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis | Lancet Planetary Health, The | 2017 | 569 |
| 27 | Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease | Clinical Gastroenterology and Hepatology | 2013 | 564 |
| 28 | Associations between Hemodialysis Access Type and Clinical Outcomes | Journal of the American Society of Nephrology: JASN | 2013 | 560 |
| 29 | Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients | Seminars in Arthritis and Rheumatism | 2004 | 549 |
| 30 | Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies | BMJ, The | 2013 | 537 |
| 31 | Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factorα Signaling during Peripheral Organ Inflammation | Journal of Neuroscience | 2009 | 535 |
| 32 | Hydrogen and Methane-Based Breath Testing in Gastrointestinal Disorders: The North American Consensus | American Journal of Gastroenterology | 2017 | 525 |
| 33 | Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia | Nature Genetics | 2011 | 524 |
| 34 | Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens | Nature Genetics | 2014 | 505 |
| 35 | The global burden of kidney disease and the sustainable development goals | Bulletin of the World Health Organization | 2018 | 504 |
| 36 | Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial | Lancet Neurology, The | 2007 | 495 |
| 37 | Early recognition and prevention of chronic kidney disease | Lancet, The | 2010 | 494 |
| 38 | The four epidemiological stages in the global evolution of inflammatory bowel disease | Nature Reviews Gastroenterology and Hepatology | 2021 | 492 |
| 39 | Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease | Annals of the Rheumatic Diseases | 2013 | 484 |
| 40 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 41 | Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial | Lancet, The | 2017 | 469 |
| 42 | Double blind, placebo controlled trial of metronidazole in Crohn's disease. | Gut | 1991 | 459 |
| 43 | Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects | Journal of Applied Physiology | 1997 | 459 |
| 44 | The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD | Journal of the American Society of Nephrology: JASN | 2010 | 456 |
| 45 | Effect of Oral Capsule– vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection | JAMA - Journal of the American Medical Association | 2017 | 446 |
| 46 | Bleeding and Perforation After Outpatient Colonoscopy and Their Risk Factors in Usual Clinical Practice | Gastroenterology | 2008 | 445 |
| 47 | Advances in the GRADE approach to rate the certainty in estimates from a network meta-analysis | Journal of Clinical Epidemiology | 2018 | 433 |
| 48 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 49 | ACG and CAG Clinical Guideline: Management of Dyspepsia | American Journal of Gastroenterology | 2017 | 431 |
| 50 | Feasibility and diagnostic performance of the FibroScan XL probe for liver stiffness measurement in overweight and obese patients | Hepatology | 2012 | 418 |
