| # | Title | Journal | Year | Citations |
|---|
| 1 | Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics | Nature Reviews Gastroenterology and Hepatology | 2017 | 3,192 |
| 2 | Canadian 24-Hour Movement Guidelines for Children and Youth: An Integration of Physical Activity, Sedentary Behaviour, and Sleep | Applied Physiology, Nutrition and Metabolism | 2016 | 1,099 |
| 3 | 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus | Arthritis and Rheumatology | 2019 | 1,098 |
| 4 | Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016 | Brain Stimulation | 2016 | 971 |
| 5 | An emerging role for neutrophil extracellular traps in noninfectious disease | Nature Medicine | 2017 | 868 |
| 6 | Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group | Molecular Psychiatry | 2016 | 850 |
| 7 | The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics | Nature Reviews Gastroenterology and Hepatology | 2020 | 826 |
| 8 | 2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult | Canadian Journal of Cardiology | 2016 | 775 |
| 9 | 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 759 |
| 10 | Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial | Lancet Respiratory Medicine,the | 2016 | 754 |
| 11 | Impact of COVID-19 pandemic on utilisation of healthcare services: a systematic review | BMJ Open | 2021 | 671 |
| 12 | Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy | Science | 2020 | 635 |
| 13 | Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis | Lancet Planetary Health, The | 2017 | 569 |
| 14 | Chronic kidney disease | Nature Reviews Disease Primers | 2017 | 558 |
| 15 | Endocannabinoid signaling at the periphery: 50 years after THC | Trends in Pharmacological Sciences | 2015 | 524 |
| 16 | How to practice person‐centred care: A conceptual framework | Health Expectations | 2018 | 478 |
| 17 | Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2018 | 474 |
| 18 | Advances in the GRADE approach to rate the certainty in estimates from a network meta-analysis | Journal of Clinical Epidemiology | 2018 | 433 |
| 19 | Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis | Journal of Allergy and Clinical Immunology | 2020 | 419 |
| 20 | Expanding antigen-specific regulatory networks to treat autoimmunity | Nature | 2016 | 409 |
| 21 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 22 | Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas | Cancer Cell | 2018 | 396 |
| 23 | TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure | Nature Communications | 2018 | 388 |
| 24 | 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults | Canadian Journal of Cardiology | 2021 | 367 |
| 25 | Variable selection strategies and its importance in clinical prediction modelling | Family Medicine and Community Health | 2020 | 356 |
| 26 | Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages | Clinical Microbiology Reviews | 2019 | 346 |
| 27 | Prevalence of Depression in Patients With Mild Cognitive Impairment | JAMA Psychiatry | 2017 | 342 |
| 28 | Effect of Dapagliflozin on Worsening Heart Failure and Cardiovascular Death in Patients With Heart Failure With and Without Diabetes | JAMA - Journal of the American Medical Association | 2020 | 340 |
| 29 | Salt Reduction Initiatives around the World – A Systematic Review of Progress towards the Global Target | PLoS ONE | 2015 | 338 |
| 30 | Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta‐analysis of European, North American and Australian cohorts | BJOG: an International Journal of Obstetrics and Gynaecology | 2019 | 327 |
| 31 | Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases | Kidney International | 2021 | 325 |
| 32 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 33 | Core principles of assessment in competency-based medical education | Medical Teacher | 2017 | 322 |
| 34 | Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials | BMJ, The | 2021 | 322 |
| 35 | Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline | Experimental Gerontology | 2017 | 302 |
| 36 | Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis | PLoS Medicine | 2019 | 291 |
| 37 | Imaging features and safety and efficacy of endovascular stroke treatment: a meta-analysis of individual patient-level data | Lancet Neurology, The | 2018 | 281 |
| 38 | Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data | Lancet Neurology, The | 2019 | 276 |
| 39 | Sympathy, empathy, and compassion: A grounded theory study of palliative care patients’ understandings, experiences, and preferences | Palliative Medicine | 2017 | 272 |
| 40 | American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism | Blood Advances | 2018 | 271 |
| 41 | Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema | Cell | 2020 | 271 |
| 42 | Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014–2015 | Frontiers in Immunology | 2015 | 270 |
| 43 | Complications of Shoulder Arthroplasty | Journal of Bone and Joint Surgery - Series A | 2017 | 270 |
| 44 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 45 | Compassion: a scoping review of the healthcare literature | BMC Palliative Care | 2016 | 268 |
| 46 | World guidelines for falls prevention and management for older adults: a global initiative | Age and Ageing | 2022 | 263 |
| 47 | Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer | JAMA Oncology | 2017 | 260 |
| 48 | The incidence of concussion in youth sports: a systematic review and meta-analysis | British Journal of Sports Medicine | 2016 | 259 |
| 49 | Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer | Nature Medicine | 2019 | 259 |
| 50 | Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia | Nature Medicine | 2018 | 258 |
