| # | Title | Journal | Year | Citations |
|---|
| 1 | The Systems Biology Graphical Notation | Nature Biotechnology | 2009 | 828 |
| 2 | BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models | BMC Systems Biology | 2010 | 467 |
| 3 | The Glycolytic Flux in Escherichia coli Is Controlled by the Demand for ATP | Journal of Bacteriology | 2002 | 315 |
| 4 | Web-based kinetic modelling using JWS Online | Bioinformatics | 2004 | 295 |
| 5 | South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides—A review | Journal of Ethnopharmacology | 2008 | 269 |
| 6 | Defining and measuring autophagosome flux—concept and reality | Autophagy | 2014 | 225 |
| 7 | Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review | Journal of Steroid Biochemistry and Molecular Biology | 2019 | 225 |
| 8 | A new subfamilial and tribal classification of the pantropical flowering plant family Annonaceae informed by molecular phylogenetics | Botanical Journal of the Linnean Society | 2012 | 222 |
| 9 | Origin and diversification of the Greater Cape flora: Ancient species repository, hot-bed of recent radiation, or both? | Molecular Phylogenetics and Evolution | 2009 | 198 |
| 10 | Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception | Steroids | 2011 | 198 |
| 11 | 11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome | Journal of Clinical Endocrinology and Metabolism | 2017 | 192 |
| 12 | Improvements in the isolation of igy from the yolks of eggs laid by immunized hens | Immunological Investigations | 1985 | 186 |
| 13 | Regulating the cellular economy of supply and demand | FEBS Letters | 2000 | 184 |
| 14 | Early evolutionary history of the flowering plant family Annonaceae: steady diversification and boreotropical geodispersal | Journal of Biogeography | 2011 | 184 |
| 15 | Metabolic engineering of for the synthesis of the wine-related antioxidant resveratrol | FEMS Yeast Research | 2003 | 175 |
| 16 | High-level resistance to class IIa bacteriocins is associated with one general mechanism in Listeria monocytogenes | Microbiology (United Kingdom) | 2002 | 173 |
| 17 | Atomic Force Microscopy Study of the Effect of Antimicrobial Peptides on the Cell Envelope of Escherichia coli | Antimicrobial Agents and Chemotherapy | 2005 | 161 |
| 18 | Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis | Plant Physiology | 2014 | 154 |
| 19 | Metabolic control analysis of moiety‐conserved cycles | FEBS Journal | 1986 | 152 |
| 20 | Antifungal peptides: To be or not to be membrane active | Biochimie | 2016 | 152 |
| 21 | 11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: A putative role in castration resistant prostate cancer? | Molecular and Cellular Endocrinology | 2013 | 148 |
| 22 | Minimum Information About a Simulation Experiment (MIASE) | PLoS Computational Biology | 2011 | 133 |
| 23 | Analysis of sucrose accumulation in the sugar cane culm on the basis of in vitro kinetic data | Biochemical Journal | 2001 | 132 |
| 24 | Synthetic progestins used in HRT have different glucocorticoid agonist properties | Molecular and Cellular Endocrinology | 2005 | 132 |
| 25 | Network Analysis of Enzyme Activities and Metabolite Levels and Their Relationship to Biomass in a Large Panel ofArabidopsisAccessions | Plant Cell | 2010 | 131 |
| 26 | Quantitative assessment of regulation in metabolic systems | FEBS Journal | 1991 | 126 |
| 27 | Understanding Glucose Transport by the Bacterial Phosphoenolpyruvate:Glycose Phosphotransferase System on the Basis of Kinetic Measurements in Vitro | Journal of Biological Chemistry | 2000 | 115 |
| 28 | 11-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored | PLoS ONE | 2016 | 113 |
| 29 | Extinction Risk and Diversification Are Linked in a Plant Biodiversity Hotspot | PLoS Biology | 2011 | 112 |
| 30 | A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids | Molecular and Cellular Endocrinology | 2017 | 112 |
| 31 | Ligand-selective transactivation and transrepression via the glucocorticoid receptor: Role of cofactor interaction | Molecular and Cellular Endocrinology | 2009 | 109 |
| 32 | Characterisation and antimicrobial activity of biosurfactant extracts produced by Bacillus amyloliquefaciens and Pseudomonas aeruginosa isolated from a wastewater treatment plant | AMB Express | 2017 | 108 |
| 33 | Metabolic Control Analysis of Glycerol Synthesis in Saccharomyces cerevisiae | Applied and Environmental Microbiology | 2002 | 107 |
| 34 | Role of Hexose Transport in Control of Glycolytic Flux in Saccharomyces cerevisiae | Applied and Environmental Microbiology | 2004 | 107 |
| 35 | Towards building the silicon cell: A modular approach | BioSystems | 2006 | 107 |
| 36 | Inhibition of tumour promotion in mouse skin by extracts of rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia), unique South African herbal teas | Cancer Letters | 2005 | 106 |
| 37 | Molecular phylogenetics of Vandeae (Orchidaceae) and the evolution of leaflessness | American Journal of Botany | 2006 | 106 |
| 38 | Kinetic model of sucrose accumulation in maturing sugarcane culm tissue | Phytochemistry | 2007 | 103 |
| 39 | Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver | Food and Chemical Toxicology | 2009 | 103 |
| 40 | Cell-surface alterations in class IIa bacteriocin-resistant Listeria monocytogenes strains | Microbiology (United Kingdom) | 2004 | 99 |
| 41 | FAIRDOMHub: a repository and collaboration environment for sharing systems biology research | Nucleic Acids Research | 2017 | 98 |
| 42 | A broader model for C 4 photosynthesis evolution in plants inferred from the goosefoot family (Chenopodiaceae s.s.) | Proceedings of the Royal Society B: Biological Sciences | 2012 | 96 |
| 43 | Feed-water pretreatment: methods to reduce membrane fouling by natural organic matter | Journal of Membrane Science | 1999 | 95 |
| 44 | Expression of mptC of Listeria monocytogenes induces sensitivity to class IIa bacteriocins in Lactococcus lactis | Microbiology (United Kingdom) | 2004 | 95 |
| 45 | Analysis of sucrose accumulation in the sugar cane culm on the basis of in vitro kinetic data | Biochemical Journal | 2001 | 89 |
| 46 | Effect of fruit maturity and growing location on the postharvest contents of flavonoids, phenolic acids, vitamin C and antioxidant activity of pomegranate juice (cv. Wonderful) | Scientia Horticulturae | 2014 | 89 |
| 47 | Kinetic modelling of plant metabolic pathways | Journal of Experimental Botany | 2012 | 87 |
| 48 | A sensitive standardised micro-gel well diffusion assay for the determination of antimicrobial activity | Journal of Microbiological Methods | 2000 | 85 |
| 49 | Estimating the age of fire in the Cape flora of South Africa from an orchid phylogeny | Proceedings of the Royal Society B: Biological Sciences | 2011 | 85 |
| 50 | Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism | Endocrine Reviews | 2019 | 84 |
