Harvard Medical School

103(top 1%)

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16.3K(top 1%)

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54(top 1%)

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91(top 1%)

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131

all documents

17.7K

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3.2K

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216

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Top Articles

#	Title	Journal	Year	Citations
1	Identification and characterization of essential genes in the human genome	Science	2015	1,461
2	Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways	Cancer Research	2008	1,298
3	Behavior, Purpose and Teleology	Philosophy of Science	1943	1,296
4	Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix	Science	2004	1,236
5	Ensemble quantum computing by NMR spectroscopy	Proceedings of the National Academy of Sciences of the United States of America	1997	824
6	Multiple neural spike train data analysis: state-of-the-art and future challenges	Nature Neuroscience	2004	734
7	Ribosome Profiling Provides Evidence that Large Noncoding RNAs Do Not Encode Proteins	Cell	2013	678
8	Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks	Cell	2012	621
9	Functional Neuroimaging of Attention-Deficit/Hyperactivity Disorder: A Review and Suggested Future Directions	Biological Psychiatry	2005	607
10	Physicochemical modelling of cell signalling pathways	Nature Cell Biology	2006	558
11	Systems biology and combination therapy in the quest for clinical efficacy	Nature Chemical Biology	2006	505
12	Automated segmentation of hippocampal subfields from ultra‐high resolution in vivo MRI	Hippocampus	2009	381
13	Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells	Molecular Cell	2008	357
14	Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence	Cell	2019	347
15	Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges	PLoS ONE	2010	337
16	Homology of a yeast actin-binding protein to signal transduction proteins and myosin-I	Nature	1990	313
17	Logic-Based Models for the Analysis of Cell Signaling Networks	Biochemistry	2010	306
18	Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis	Nature	2005	303
19	A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors	Nature Genetics	2017	290
20	Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death	PLoS Biology	2008	252
21	Informatics and Quantitative Analysis in Biological Imaging	Science	2003	249
22	Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling	Proceedings of the National Academy of Sciences of the United States of America	2010	236
23	A Comparison of Machine Learning Methods for the Diagnosis of Pigmented Skin Lesions	Journal of Biomedical Informatics	2001	229
24	Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion	Proceedings of the National Academy of Sciences of the United States of America	2011	228
25	Chlorination by a Long-Lived Intermediate in the Mechanism of Flavin-Dependent Halogenases†,‖	Biochemistry	2007	209
26	The Logic of EGFR/ErbB Signaling: Theoretical Properties and Analysis of High-Throughput Data	PLoS Computational Biology	2009	164
27	Predictors of disease relapse in IgG4-related disease following rituximab	Rheumatology	2016	151
28	NMR Structural Investigation of the Mitochondrial Outer Membrane Protein VDAC and Its Interaction with Antiapoptotic Bcl-xL†	Biochemistry	2007	148
29	STRUCTURAL AND CHEMICAL STUDIES ON THE CONNECTIVE TISSUE OF MARINE SPONGES	Journal of Histochemistry and Cytochemistry	1956	138
30	Gray Matter Alterations in Adults with Attention-Deficit/Hyperactivity Disorder Identified by Voxel Based Morphometry	Biological Psychiatry	2011	137
31	Comparing Three-class Diagnostic Tests by Three-way ROC Analysis	Medical Decision Making	2000	135
32	Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models	Cancer Research	2011	132
33	Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding	Molecular Cell	2011	118
34	Mps1 at kinetochores is essential for female mouse meiosis I	Development (Cambridge)	2011	114
35	Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data	PLoS Computational Biology	2009	112
36	Changing Mad2 Levels Affects Chromosome Segregation and Spindle Assembly Checkpoint Control in Female Mouse Meiosis I	PLoS ONE	2007	104
37	Modeling Medical Prognosis: Survival Analysis Techniques	Journal of Biomedical Informatics	2001	102
38	Collecting and organizing systematic sets of protein data	Nature Reviews Molecular Cell Biology	2006	98
39	Targeting CXCR4-dependent immunosuppressive Ly6C ^low monocytes improves antiangiogenic therapy in colorectal cancer	Proceedings of the National Academy of Sciences of the United States of America	2017	97
40	A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling	Nature Cell Biology	2007	95
41	Networks Inferred from Biochemical Data Reveal Profound Differences in Toll-like Receptor and Inflammatory Signaling between Normal and Transformed Hepatocytes	Molecular and Cellular Proteomics	2010	95
42	Staying in the Loop: Relational Agency and Identity in Next-Generation DBS for Psychiatry	AJOB Neuroscience	2017	92
43	A complex network of factors with overlapping affinities represses splicing through intronic elements	Nature Structural and Molecular Biology	2013	90
44	Retinal imaging in Alzheimer's and neurodegenerative diseases	Alzheimer's and Dementia	2021	89
45	Laminar Analysis of Human Neocortical Interictal Spike Generation and Propagation: Current Source Density and Multiunit Analysis In Vivo	Epilepsia	2004	83
46	Magic Angle Spinning NMR Investigation of Influenza A M2₁₈₋₆₀: Support for an Allosteric Mechanism of Inhibition	Journal of the American Chemical Society	2010	82
47	Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function	Genome Biology	2008	78
48	Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3	Journal of the American Chemical Society	2009	76
49	Molecular Diagnosis of Central Nervous System Opportunistic Infections in HIV-Infected Zambian Adults	Clinical Infectious Diseases	2014	70
50	Fundamental Considerations in Designing Auditory Implants	Acta Oto-Laryngologica	1979	67

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