| # | Title | Journal | Year | Citations |
|---|
| 1 | NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells | Blood | 2002 | 1,322 |
| 2 | Ubiquitin ligases: cell-cycle control and cancer | Nature Reviews Cancer | 2006 | 1,259 |
| 3 | Influenza virus receptors in the human airway | Nature | 2006 | 1,222 |
| 4 | Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer | International Journal of Clinical Oncology | 2018 | 1,187 |
| 5 | The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis | Physiological Reviews | 2018 | 1,067 |
| 6 | Heart failure: preventing disease and death worldwide | ESC Heart Failure | 2014 | 921 |
| 7 | Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool | Cell Stem Cell | 2007 | 780 |
| 8 | Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort | Lancet Diabetes and Endocrinology,the | 2017 | 595 |
| 9 | International standardization of diagnostic criteria for microvascular angina | International Journal of Cardiology | 2018 | 494 |
| 10 | Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial | Lancet, The | 2016 | 445 |
| 11 | Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence | Nature Cell Biology | 2006 | 439 |
| 12 | Unique multipotent cells in adult human mesenchymal cell populations | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 428 |
| 13 | The Mechanisms of UV Mutagenesis | Journal of Radiation Research | 2011 | 419 |
| 14 | Asian diagnostic criteria for autoimmune pancreatitis: consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis | Journal of Gastroenterology | 2008 | 418 |
| 15 | MG53 nucleates assembly of cell membrane repair machinery | Nature Cell Biology | 2009 | 396 |
| 16 | Intelligent Image-Activated Cell Sorting | Cell | 2018 | 395 |
| 17 | The KEAP1–NRF2 System in Cancer | Frontiers in Oncology | 2017 | 370 |
| 18 | JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome | Circulation Journal | 2019 | 324 |
| 19 | AUTACs: Cargo-Specific Degraders Using Selective Autophagy | Molecular Cell | 2019 | 319 |
| 20 | Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart | Journal of Cell Biology | 2005 | 310 |
| 21 | Thermo‐triggered Release of CRISPR‐Cas9 System by Lipid‐Encapsulated Gold Nanoparticles for Tumor Therapy | Angewandte Chemie - International Edition | 2018 | 306 |
| 22 | A Randomized, Observer-Blind, Controlled Trial of the Traditional Chinese Medicine Yi-Gan San for Improvement of Behavioral and Psychological Symptoms and Activities of Daily Living in Dementia Patients | Journal of Clinical Psychiatry | 2005 | 300 |
| 23 | 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease | Brain | 2011 | 299 |
| 24 | Anesthetics, immune cells, and immune responses | Journal of Anesthesia | 2008 | 298 |
| 25 | Percutaneous Transluminal Pulmonary Angioplasty Markedly Improves Pulmonary Hemodynamics and Long-Term Prognosis in Patients With Chronic Thromboembolic Pulmonary Hypertension | Circulation Journal | 2012 | 290 |
| 26 | p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells | Cell Stem Cell | 2011 | 268 |
| 27 | Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on Item Response Theory | Sleep Medicine | 2009 | 256 |
| 28 | p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70 | Cell Stem Cell | 2011 | 247 |
| 29 | Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer | Nature Communications | 2017 | 246 |
| 30 | Increased [18F]Fluorodeoxyglucose Accumulation in Right Ventricular Free Wall in Patients With Pulmonary Hypertension and the Effect of Epoprostenol | Journal of the American College of Cardiology | 2005 | 241 |
| 31 | Development of Azo‐Based Fluorescent Probes to Detect Different Levels of Hypoxia | Angewandte Chemie - International Edition | 2013 | 241 |
| 32 | The Tohoku Medical Megabank Project: Design and Mission | Journal of Epidemiology | 2016 | 236 |
| 33 | An Association Between Long-Term Exposure to Ambient Air Pollution and Mortality From Lung Cancer and Respiratory Diseases in Japan | Journal of Epidemiology | 2011 | 223 |
| 34 | Enzymatic biofuel cells designed for direct power generation from biofluids in living organisms | Energy and Environmental Science | 2011 | 221 |
| 35 | Behavioral Characterization of Mice Lacking Histamine H3 Receptors | Molecular Pharmacology | 2002 | 215 |
| 36 | Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis | Journal of Gastroenterology | 2014 | 207 |
| 37 | Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease | Nature Genetics | 2020 | 206 |
| 38 | Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds | Wound Repair and Regeneration | 2017 | 204 |
| 39 | DNER acts as a neuron-specific Notch ligand during Bergmann glial development | Nature Neuroscience | 2005 | 200 |
| 40 | JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis | Journal of Hepato-Biliary-Pancreatic Surgery | 2006 | 190 |
| 41 | Rho Kinase Inhibition by Fasudil Ameliorates Diabetes-Induced Microvascular Damage | Diabetes | 2009 | 188 |
| 42 | Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus Guidelines From the Guidelines Committee of Idiopathic Normal Pressure Hydrocephalus, the Japanese Society of Normal Pressure Hydrocephalus | Neurologia Medico-Chirurgica | 2008 | 185 |
| 43 | Signal transduction in pancreatic stellate cells | Journal of Gastroenterology | 2009 | 185 |
| 44 | The Great East Japan Earthquake Disaster and cardiovascular diseases | European Heart Journal | 2012 | 183 |
| 45 | Role of TGF-β in proliferative vitreoretinal diseases and ROCK as a therapeutic target | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 177 |
| 46 | Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan: Report From the MIYAGI-AMI Registry Study | Circulation Journal | 2010 | 176 |
| 47 | Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy | British Journal of Surgery | 2012 | 176 |
| 48 | Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model | Molecular Therapy | 2011 | 174 |
| 49 | The Brainstem Noradrenergic Systems in Stress, Anxiety and Depression | Journal of Neuroendocrinology | 2010 | 173 |
| 50 | Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development | Development (Cambridge) | 2006 | 169 |
