| # | Title | Journal | Year | Citations |
|---|
| 1 | Multiplex Genome Engineering Using CRISPR/Cas Systems | Science | 2013 | 12,725 |
| 2 | Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons | Proteins: Structure, Function and Bioinformatics | 1991 | 5,360 |
| 3 | A novel multigene family may encode odorant receptors: A molecular basis for odor recognition | Cell | 1991 | 4,469 |
| 4 | Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody | Nature | 1998 | 2,788 |
| 5 | Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus | BMC Developmental Biology | 2001 | 2,753 |
| 6 | Classical electrostatics in biology and chemistry | Science | 1995 | 2,743 |
| 7 | The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain | Cell | 1986 | 2,240 |
| 8 | Neuronal specification in the spinal cord: inductive signals and transcriptional codes | Nature Reviews Genetics | 2000 | 1,878 |
| 9 | A hierarchical approach to all-atom protein loop prediction | Proteins: Structure, Function and Bioinformatics | 2004 | 1,874 |
| 10 | Visualizing an Olfactory Sensory Map | Cell | 1996 | 1,825 |
| 11 | Directed Differentiation of Embryonic Stem Cells into Motor Neurons | Cell | 2002 | 1,622 |
| 12 | DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 | Nature | 2014 | 1,573 |
| 13 | Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters | Nature | 2005 | 1,564 |
| 14 | Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex | Structure | 1993 | 1,283 |
| 15 | Electrostatic Interactions in Macromolecules: Theory and Applications | Annual Review of Biophysics and Biophysical Chemistry | 1990 | 1,268 |
| 16 | The PredictProtein server | Nucleic Acids Research | 2004 | 1,246 |
| 17 | Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK | Science | 1996 | 1,209 |
| 18 | A rapid finite difference algorithm, utilizing successive over-relaxation to solve the Poisson-Boltzmann equation | Journal of Computational Chemistry | 1991 | 1,194 |
| 19 | Topographic organization of sensory projections to the olfactory bulb | Cell | 1994 | 1,172 |
| 20 | The antigenic structure of the HIV gp120 envelope glycoprotein | Nature | 1998 | 1,152 |
| 21 | Determination of macromolecular structures from anomalous diffraction of synchrotron radiation | Science | 1991 | 1,150 |
| 22 | Structural basis of cell-cell adhesion by cadherins | Nature | 1995 | 1,124 |
| 23 | Crystal structure of the tyrosine kinase domain of the human insulin receptor | Nature | 1994 | 1,105 |
| 24 | A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube | Cell | 2000 | 1,065 |
| 25 | Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons | Nature Neuroscience | 2007 | 1,065 |
| 26 | Calculating the electrostatic potential of molecules in solution: Method and error assessment | Journal of Computational Chemistry | 1988 | 1,017 |
| 27 | On the Role of the Crystal Environment in Determining Protein Side-chain Conformations | Journal of Molecular Biology | 2002 | 1,002 |
| 28 | Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm | Cell | 1995 | 989 |
| 29 | Allelic inactivation regulates olfactory receptor gene expression | Cell | 1994 | 985 |
| 30 | Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus | Nature | 2013 | 961 |
| 31 | Structure of a C-type mannose-binding protein complexed with an oligosaccharide | Nature | 1992 | 953 |
| 32 | Backbone Dynamics ofEscherichia coliRibonuclease HI: Correlations with Structure and Function in an Active Enzyme | Journal of Molecular Biology | 1995 | 948 |
| 33 | Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes | Cell | 1994 | 942 |
| 34 | Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling | Cell | 1997 | 939 |
| 35 | Catalytic specificity of protein-tyrosine kinases is critical for selective signalling | Nature | 1995 | 932 |
| 36 | Two distinct classes of carbohydrate-recognition domains in animal lectins | Journal of Biological Chemistry | 1988 | 928 |
| 37 | A novel family of genes encoding putative pheromone receptors in mammals | Cell | 1995 | 927 |
| 38 | The role of DNA shape in protein–DNA recognition | Nature | 2009 | 918 |
| 39 | Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor | Neuron | 2000 | 874 |
| 40 | Emerging structure of the Nicotinic Acetylcholine receptors | Nature Reviews Neuroscience | 2002 | 834 |
| 41 | Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord | Cell | 1994 | 833 |
| 42 | HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites | Nature | 2002 | 832 |
| 43 | Nuclear Magnetic Resonance Methods for Quantifying Microsecond-to-Millisecond Motions in Biological Macromolecules | Methods in Enzymology | 2001 | 823 |
| 44 | Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity | Cell | 1996 | 818 |
| 45 | Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium | Cell | 1993 | 811 |
| 46 | Calculation of the total electrostatic energy of a macromolecular system: Solvation energies, binding energies, and conformational analysis | Proteins: Structure, Function and Bioinformatics | 1988 | 794 |
| 47 | Origins of Specificity in Protein-DNA Recognition | Annual Review of Biochemistry | 2010 | 791 |
| 48 | NMR Characterization of the Dynamics of Biomacromolecules | Chemical Reviews | 2004 | 774 |
| 49 | Structure of a glutamate transporter homologue from Pyrococcus horikoshii | Nature | 2004 | 758 |
| 50 | Two-Photon Calcium Imaging Reveals an Odor-Evoked Map of Activity in the Fly Brain | Cell | 2003 | 752 |
