| # | Title | Journal | Year | Citations |
|---|
| 1 | Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial | Lancet, The | 2002 | 2,331 |
| 2 | TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis | Nature Genetics | 2008 | 1,371 |
| 3 | Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects | Journal of Allergy and Clinical Immunology | 2018 | 344 |
| 4 | ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells | Stem Cells and Development | 2009 | 298 |
| 5 | SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations | Journal of Medical Genetics | 2010 | 266 |
| 6 | Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer | Nature Medicine | 2022 | 225 |
| 7 | Interstitial lung diseases induced or exacerbated by DMARDS and biologic agents in rheumatoid arthritis: A systematic literature review | Seminars in Arthritis and Rheumatism | 2014 | 223 |
| 8 | Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts | American Journal of Human Genetics | 2010 | 222 |
| 9 | Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial | Nature Medicine | 2021 | 206 |
| 10 | The STOP-NIDDM Trial: An international study on the efficacy of an -glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data | Diabetes Care | 1998 | 179 |
| 11 | Use of Mycophenolate Mofetil or Azathioprine for the Management of Chronic Hypersensitivity Pneumonitis | Chest | 2017 | 177 |
| 12 | Buparlisib and paclitaxel in patients with platinum-pretreated recurrent or metastatic squamous cell carcinoma of the head and neck (BERIL-1): a randomised, double-blind, placebo-controlled phase 2 trial | Lancet Oncology, The | 2017 | 173 |
| 13 | Oxytocin is a cardiovascular hormone | Brazilian Journal of Medical and Biological Research | 2000 | 169 |
| 14 | ACTH-independent macronodular adrenal hyperplasia | Best Practice and Research in Clinical Endocrinology and Metabolism | 2009 | 169 |
| 15 | Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report | PLoS ONE | 2013 | 156 |
| 16 | Frataxin knockin mouse | FEBS Letters | 2002 | 155 |
| 17 | Treatment of Patients with a History of Penicillin Allergy in a Large Tertiary-Care Academic Hospital | Journal of Allergy and Clinical Immunology: in Practice | 2013 | 153 |
| 18 | Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes | Osteoarthritis and Cartilage | 2008 | 151 |
| 19 | How Effective Are Supplementary Doses of Opioids for Dyspnea in Terminally Ill Cancer Patients? A Randomized Continuous Sequential Clinical Trial | Journal of Pain and Symptom Management | 1999 | 147 |
| 20 | Head-to-head comparison of certolizumab pegol versus adalimumab in rheumatoid arthritis: 2-year efficacy and safety results from the randomised EXXELERATE study | Lancet, The | 2016 | 144 |
| 21 | Update on the Pharmacological Treatment of Alzheimers Disease | Current Neuropharmacology | 2010 | 129 |
| 22 | Common polymorphisms of the PPAR-?2 (Pro12Ala) and PGC-1? (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial | Diabetologia | 2004 | 120 |
| 23 | Frequent mutations of β‐catenin gene in sporadic secreting adrenocortical adenomas* | Clinical Endocrinology | 2008 | 100 |
| 24 | Methotrexate Drug Interactions in the Treatment of Rheumatoid Arthritis: A Systematic Review | Journal of Rheumatology | 2010 | 100 |
| 25 | Acarbose for the Prevention of Diabetes, Hypertension, and Cardiovascular Disease in Subjects with Impaired Glucose Tolerance: The Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (Stop-Niddm) Trial | Endocrine Practice | 2006 | 95 |
| 26 | Pasireotide treatment significantly improves clinical signs and symptoms in patients with Cushing's disease: results from a Phase III study | Clinical Endocrinology | 2014 | 95 |
| 27 | Ramipril versus placebo in kidney transplant patients with proteinuria: a multicentre, double-blind, randomised controlled trial | Lancet Diabetes and Endocrinology,the | 2016 | 93 |
| 28 | Association Between Gut Microbiota and CD4 Recovery in HIV-1 Infected Patients | Frontiers in Microbiology | 2018 | 90 |
| 29 | Mapping of a Gene Determining Familial Partial Epilepsy with Variable Foci to Chromosome 22q11-q12 | American Journal of Human Genetics | 1999 | 89 |
| 30 | Association of Sex with Risk of Kidney Graft Failure Differs by Age | Journal of the American Society of Nephrology: JASN | 2017 | 85 |
| 31 | The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation | Frontiers in Immunology | 2020 | 84 |
| 32 | Microbiota-Centered Interventions: The Next Breakthrough in Immuno-Oncology? | Cancer Discovery | 2021 | 81 |
| 33 | Adenosine 5′-Monophosphate-Activated Protein Kinase and p38 Mitogen-Activated Protein Kinase Participate in the Stimulation of Glucose Uptake by Dinitrophenol in Adult Cardiomyocytes | Endocrinology | 2005 | 78 |
| 34 | Patients receiving frequent hemodialysis have better health-related quality of life compared to patients receiving conventional hemodialysis | Kidney International | 2017 | 78 |
| 35 | Adrenocortical Overexpression of Gastric Inhibitory Polypeptide Receptor Underlies Food-Dependent Cushing’s Syndrome1 | Journal of Clinical Endocrinology and Metabolism | 1998 | 76 |
| 36 | Corticosteroid therapy for sepsis: a clinical practice guideline | BMJ: British Medical Journal | 2018 | 76 |
| 37 | “Hook Effect” in Calcitonin Immunoradiometric Assay in Patients with Metastatic Medullary Thyroid Carcinoma: Case Report and Review of the Literature | Journal of Clinical Endocrinology and Metabolism | 2006 | 74 |
| 38 | Controversies in Drug Allergy: Radiographic Contrast Media | Journal of Allergy and Clinical Immunology: in Practice | 2019 | 72 |
| 39 | Manganese superoxide dismutase induction by iron is impaired in Friedreich ataxia cells | FEBS Letters | 2001 | 71 |
| 40 | Frataxin deficiency enhances apoptosis in cells differentiating into neuroectoderm | Human Molecular Genetics | 2001 | 71 |
| 41 | No relationship between mean plasma glucose and glycated haemoglobin in patients with cystic fibrosis-related diabetes | Diabetes and Metabolism | 2008 | 71 |
| 42 | The impact of perioperative red blood cell transfusions in patients undergoing liver resection: a systematic review | Hpb | 2017 | 70 |
| 43 | Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes | Arthritis Research and Therapy | 2007 | 69 |
| 44 | Cardiac Rehabilitation During the COVID-19 Era: Guidance on Implementing Virtual Care | Canadian Journal of Cardiology | 2020 | 68 |
| 45 | Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain | Science | 2022 | 68 |
| 46 | Dose reduction of baricitinib in patients with rheumatoid arthritis achieving sustained disease control: results of a prospective study | Annals of the Rheumatic Diseases | 2019 | 66 |
| 47 | Multimorbidity Patterns, Frailty, and Survival in Community-Dwelling Older Adults | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2019 | 64 |
| 48 | Eligibility Criteria for Deep Brain Stimulation in Parkinson’s Disease, Tremor, and Dystonia | Canadian Journal of Neurological Sciences | 2016 | 63 |
| 49 | Treatment Algorithm in Cancer-Associated Thrombosis: Canadian Expert Consensus | Current Oncology | 2018 | 62 |
| 50 | Heredity and Cortisol Regulation in Bilateral Macronodular Adrenal Hyperplasia | New England Journal of Medicine | 2013 | 60 |
