| # | Title | Journal | Year | Citations |
|---|
| 1 | Hypertension in mice lacking the gene for endothelial nitric oxide synthase | Nature | 1995 | 1,932 |
| 2 | ADHD: Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents | Pediatrics | 2011 | 1,545 |
| 3 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial | Lancet Oncology, The | 2010 | 1,477 |
| 4 | Analysis of radioligand binding experiments | Journal of Pharmacological Methods | 1985 | 1,194 |
| 5 | Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update | Cancer | 1983 | 924 |
| 6 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial | Lancet Oncology, The | 2007 | 915 |
| 7 | Evaluation of patients with advanced cancer using the karnofsky performance status | Cancer | 1980 | 798 |
| 8 | Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome | Nature | 2005 | 773 |
| 9 | Vasoregulation by the β1 subunit of the calcium-activated potassium channel | Nature | 2000 | 772 |
| 10 | Asbestos: scientific developments and implications for public policy | Science | 1990 | 711 |
| 11 | Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study | American Journal of Epidemiology | 2006 | 686 |
| 12 | Genetic analyses of diverse populations improves discovery for complex traits | Nature | 2019 | 679 |
| 13 | Quality of life: An approach integrating opportunities, human needs, and subjective well-being | Ecological Economics | 2007 | 672 |
| 14 | Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents | Pediatrics | 2019 | 641 |
| 15 | The Single Item Literacy Screener: Evaluation of a brief instrument to identify limited reading ability | BMC Family Practice | 2006 | 635 |
| 16 | Risk factors in low-back pain. An epidemiological survey. | Journal of Bone and Joint Surgery - Series A | 1983 | 613 |
| 17 | The epidemiology of common fears and phobia | Comprehensive Psychiatry | 1969 | 612 |
| 18 | The Measurement of the Q-T Interval of the Electrocardiogram | Circulation | 1952 | 591 |
| 19 | Calcium sparks in smooth muscle | American Journal of Physiology - Cell Physiology | 2000 | 571 |
| 20 | Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years | JAMA Pediatrics | 2018 | 551 |
| 21 | Diabetes and Endothelial Dysfunction: A Clinical Perspective | Endocrine Reviews | 2001 | 544 |
| 22 | Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population | American Journal of Epidemiology | 2001 | 491 |
| 23 | Local potassium signaling couples neuronal activity to vasodilation in the brain | Nature Neuroscience | 2006 | 487 |
| 24 | Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women | Circulation | 2002 | 486 |
| 25 | A Histochemical Procedure for Localizing and Evaluating Leukocyte Alkaline Phosphatase Activity in Smears of Blood and Marrow | Blood | 1955 | 485 |
| 26 | What is all that thrombin for? | Journal of Thrombosis and Haemostasis | 2003 | 480 |
| 27 | Elementary Ca 2+ Signals Through Endothelial TRPV4 Channels Regulate Vascular Function | Science | 2012 | 479 |
| 28 | Sleep Duration and Biomarkers of Inflammation | Sleep | 2009 | 466 |
| 29 | Transient Receptor Potential Channels Regulate Myogenic Tone of Resistance Arteries | Circulation Research | 2002 | 463 |
| 30 | The Dynamics of Thrombin Formation | Arteriosclerosis, Thrombosis, and Vascular Biology | 2003 | 459 |
| 31 | Treatment of Anterior Cruciate Ligament Injuries, Part I | American Journal of Sports Medicine | 2005 | 458 |
| 32 | Epidemiologic Studies of Low-Back Pain | Spine | 1980 | 443 |
| 33 | Cardiac Rehabilitation and Survival in Older Coronary Patients | Journal of the American College of Cardiology | 2009 | 441 |
| 34 | Interferon beta-1b in secondary progressive MS | Neurology | 2004 | 413 |
| 35 | Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy | Leukemia | 2019 | 385 |
| 36 | Prognostic value of thallium-201 myocardial perfusion imaging. A diagnostic tool comes of age. | Circulation | 1991 | 382 |
| 37 | Are there persons who are obese, but metabolically healthy? | Metabolism: Clinical and Experimental | 2001 | 381 |
| 38 | Clustering of Procoagulation, Inflammation, and Fibrinolysis Variables with Metabolic Factors in Insulin Resistance Syndrome | American Journal of Epidemiology | 2000 | 379 |
| 39 | Blood clotting in minimally altered whole blood | Blood | 1996 | 373 |
| 40 | Calcium-Activated Potassium Channels and the Regulation of Vascular Tone | Physiology | 2006 | 368 |
| 41 | Short‐Chain Fatty Acids: Ready for Prime Time? | Nutrition in Clinical Practice | 2006 | 365 |
| 42 | The effect of hypotension and hypoxia on children with severe head injuries | Journal of Pediatric Surgery | 1993 | 356 |
| 43 | Thrombin functions during tissue factor–induced blood coagulation | Blood | 2002 | 355 |
| 44 | Sensitive fluorometric method for tissue tocopherol analysis | Lipids | 1976 | 351 |
| 45 | The mechanism of inactivation of human factor V and human factor Va by activated protein C. | Journal of Biological Chemistry | 1994 | 350 |
| 46 | Antimicrobial Safety: Focus on Fluoroquinolones | Clinical Infectious Diseases | 2005 | 349 |
| 47 | A Proposal to Speed Translation of Healthcare Research Into Practice | American Journal of Preventive Medicine | 2011 | 326 |
| 48 | A Model for the Stoichiometric Regulation of Blood Coagulation | Journal of Biological Chemistry | 2002 | 324 |
| 49 | Noradrenaline contracts arteries by activating voltage-dependent calcium channels | Nature | 1988 | 323 |
| 50 | Measuring the lung function in the mouse: the challenge of size | Respiratory Research | 2003 | 320 |
