| # | Title | Journal | Year | Citations |
|---|
| 1 | Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder | Bipolar Disorders | 2018 | 1,079 |
| 2 | Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values | Journal of Pharmacology and Experimental Therapeutics | 1989 | 862 |
| 3 | Cellular changes in the postmortem hippocampus in major depression | Biological Psychiatry | 2004 | 633 |
| 4 | Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder | Nature | 2015 | 461 |
| 5 | Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior | Neuron | 2003 | 428 |
| 6 | Increase in Serotonin-1A Autoreceptors in the Midbrain of Suicide Victims with Major Depression—Postmortem Evidence for Decreased Serotonin Activity | Journal of Neuroscience | 1998 | 385 |
| 7 | Reduced Levels of Norepinephrine Transporters in the Locus Coeruleus in Major Depression | Journal of Neuroscience | 1997 | 381 |
| 8 | Interleukin-2 and interleukin-6 in schizophrenia and mania: Effects of neuroleptics and mood stabilizers | Journal of Psychiatric Research | 1995 | 379 |
| 9 | Improvement in cognitive functions and psychiatric symptoms in treatment-refractory schizophrenic patients receiving clozapine | Biological Psychiatry | 1993 | 366 |
| 10 | Methamphetamine neurotoxicity and striatal glutamate release: comparison to 3, 4-methylenedioxymethamphetamine | Brain Research | 1992 | 342 |
| 11 | Rapid Communication: Adrenalectomy Attenuates Stress-Induced Elevations in Extracellular Glutamate Concentrations in the Hippocampus | Journal of Neurochemistry | 1993 | 323 |
| 12 | Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs | Psychiatry Research | 1997 | 322 |
| 13 | Treatment of the Neuroleptic-Nonresponsive Schizophrenic Patient | Schizophrenia Bulletin | 1992 | 304 |
| 14 | Serotonergic measures in the brains of suicide victims: 5-HT2 binding sites in the frontal cortex of suicide victims and control subjects | American Journal of Psychiatry | 1989 | 300 |
| 15 | Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents | Bipolar Disorders | 2005 | 296 |
| 16 | Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex | Bipolar Disorders | 1997 | 295 |
| 17 | Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone | British Journal of Psychiatry | 2004 | 288 |
| 18 | A prospective study of clozapine in treatment-resistant schizophrenic patients | Psychopharmacology | 1989 | 245 |
| 19 | Effects of Psychotropic Drugs on Human Erection and Ejaculation | Archives of General Psychiatry | 1989 | 244 |
| 20 | Spectrum of efficacy of valproate in 55 patients with rapid-cycling bipolar disorder | American Journal of Psychiatry | 1990 | 244 |
| 21 | Immune‐inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine | Acta Psychiatrica Scandinavica | 1994 | 234 |
| 22 | Depressive symptoms, major depression, and generalized anxiety: A comparison of self-reports on CES-D and results from diagnostic interviews | Psychiatry Research | 1985 | 229 |
| 23 | Dopaminergic Modulation of Glutamate Release in Striatum as Measured by Microdialysis | Journal of Neurochemistry | 1992 | 226 |
| 24 | Impact of Bipolar Disorder on a U.S. Community Sample | Journal of Clinical Psychiatry | 2003 | 224 |
| 25 | Serotonin Subtype 2 Receptor Genes and Clinical Response to Clozapine in Schizophrenia Patients | Neuropsychopharmacology | 1998 | 220 |
| 26 | Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations | Journal of Neuroscience | 1994 | 206 |
| 27 | Carrier‐Mediated Release of Serotonin by 3,4‐Methylenedioxymethamphetamine: Implications for Serotonin‐Dopamine Interactions | Journal of Neurochemistry | 1996 | 198 |
| 28 | Serotonergic Dysfunction in Depression | British Journal of Psychiatry | 1989 | 192 |
| 29 | Effect of Acute Stress on Hippocampal Glutamate Levels and Spectrin Proteolysis in Young and Aged Rats | Journal of Neurochemistry | 1995 | 190 |
| 30 | Cost effectiveness of clozapine in neuroleptic-resistant schizophrenia | American Journal of Psychiatry | 1993 | 188 |
| 31 | Double-Blind 18-Month Trial of Lithium Versus Divalproex Maintenance Treatment in Pediatric Bipolar Disorder | Journal of the American Academy of Child and Adolescent Psychiatry | 2005 | 188 |
| 32 | Side effects of antidepressants: an overview. | Cleveland Clinic Journal of Medicine | 2006 | 188 |
| 33 | Hypozincemia in depression | Journal of Affective Disorders | 1994 | 187 |
| 34 | 'Brain death' and organ retrieval. A cross-sectional survey of knowledge and concepts among health professionals | JAMA - Journal of the American Medical Association | 1989 | 184 |
| 35 | Antipsychotic-Induced Extrapyramidal Side Effects in Bipolar Disorder and Schizophrenia | Journal of Clinical Psychopharmacology | 2008 | 181 |
| 36 | Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats | Journal of Pharmacology and Experimental Therapeutics | 1997 | 172 |
| 37 | 2D and 3D high resolution gradient echo functional imaging of the brain: Venous contributions to signal in motor cortex studies | NMR in Biomedicine | 1994 | 161 |
| 38 | Composite International Diagnostic Interview screening scales for DSM-IV anxiety and mood disorders | Psychological Medicine | 2013 | 161 |
| 39 | Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression | European Neuropsychopharmacology | 1995 | 160 |
| 40 | Acute Treatment of Pediatric Bipolar I Disorder, Manic or Mixed Episode, With Aripiprazole | Journal of Clinical Psychiatry | 2009 | 159 |
| 41 | Reduced Neuropeptide Y Concentrations in Suicide Brain | Journal of Neurochemistry | 1992 | 155 |
| 42 | Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia | Brain Research | 1996 | 155 |
| 43 | Long-Term, Open-Label Study of Risperidone in Children With Severe Disruptive Behaviors and Below-Average IQ | American Journal of Psychiatry | 2004 | 154 |
| 44 | Relationship Between Clinical Efficacy and Clozapine Concentrations in Plasma in Schizophrenia | Journal of Clinical Psychopharmacology | 1993 | 153 |
| 45 | 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: Clinical, neurodevelopmental, and cognitive correlates | Biological Psychiatry | 1994 | 150 |
| 46 | Substance abuse among patients with treatment-resistant schizophrenia: characteristics and implications for clozapine therapy | American Journal of Psychiatry | 1994 | 145 |
| 47 | Brain Activation During Silent Word Generation Evaluated with Functional MRI | Brain and Language | 1998 | 144 |
| 48 | Serotonin2 (5-HT2) receptor binding in the frontal cortex of schizophrenic patients | Journal of Neural Transmission | 1991 | 143 |
| 49 | Treatment Adherence With Lithium and Anticonvulsant Medications Among Patients With Bipolar Disorder | Psychiatric Services | 2007 | 140 |
| 50 | Agonist Binding to α2‐Adrenoceptors Is Elevated in the Locus Coeruleus from Victims of Suicide | Journal of Neurochemistry | 1994 | 137 |
