| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Development by Self-Digestion | Developmental Cell | 2004 | 3,502 |
| 3 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 4 | Induction of autophagy and inhibition of tumorigenesis by beclin 1 | Nature | 1999 | 2,991 |
| 5 | Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function | Nature Medicine | 2001 | 2,413 |
| 6 | Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene | Journal of Clinical Investigation | 2003 | 1,957 |
| 7 | PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) | Cell | 2000 | 1,856 |
| 8 | Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes | Nature | 2005 | 1,809 |
| 9 | TLR4 enhances TGF-β signaling and hepatic fibrosis | Nature Medicine | 2007 | 1,712 |
| 10 | Frequency domain measures of heart period variability and mortality after myocardial infarction. | Circulation | 1992 | 1,514 |
| 11 | Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance | Nature | 2015 | 1,498 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 13 | Antisense oligonucleotides as therapeutic agents--is the bullet really magical? | Science | 1993 | 1,411 |
| 14 | The microbiome and cancer | Nature Reviews Cancer | 2013 | 1,338 |
| 15 | The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene | Nature Genetics | 1993 | 1,307 |
| 16 | How Useful Is Body Mass Index for Comparison of Body Fatness across Age, Sex, and Ethnic Groups? | American Journal of Epidemiology | 1996 | 1,213 |
| 17 | Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure | Cell | 2012 | 1,185 |
| 18 | Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury | Nature Medicine | 2012 | 1,164 |
| 19 | Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1) | Journal of Clinical Endocrinology and Metabolism | 2012 | 1,127 |
| 20 | Anti-CD3 Monoclonal Antibody in New-Onset Type 1 Diabetes Mellitus | New England Journal of Medicine | 2002 | 1,118 |
| 21 | Amiloride and its analogs as tools in the study of ion transport | Journal of Membrane Biology | 1988 | 1,086 |
| 22 | Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 | Cancer Cell | 2012 | 1,051 |
| 23 | NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma | Nature Reviews Gastroenterology and Hepatology | 2011 | 1,049 |
| 24 | Cholesterol, inflammation and innate immunity | Nature Reviews Immunology | 2015 | 1,020 |
| 25 | Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology | Nature Communications | 2013 | 1,012 |
| 26 | Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report | American Journal of Respiratory and Critical Care Medicine | 2016 | 1,006 |
| 27 | The neurohormonal hypothesis: A theory to explain the mechanism of disease progression in heart failure | Journal of the American College of Cardiology | 1992 | 956 |
| 28 | ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 939 |
| 29 | Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale | Circulation | 2002 | 926 |
| 30 | Glucocorticoid-induced osteoporosis: pathophysiology and therapy | Osteoporosis International | 2007 | 914 |
| 31 | Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities | Science | 2013 | 905 |
| 32 | Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 | Stem Cells | 2009 | 890 |
| 33 | Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality | New England Journal of Medicine | 2015 | 881 |
| 34 | Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor | Journal of Biological Chemistry | 2000 | 874 |
| 35 | Molecular robots guided by prescriptive landscapes | Nature | 2010 | 843 |
| 36 | The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism | JAMA Surgery | 2016 | 840 |
| 37 | A 10-Year Prospective Study of Primary Hyperparathyroidism with or without Parathyroid Surgery | New England Journal of Medicine | 1999 | 822 |
| 38 | Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B | Cell | 1993 | 817 |
| 39 | Vasopressin Deficiency Contributes to the Vasodilation of Septic Shock | Circulation | 1997 | 816 |
| 40 | Increased High-Density Lipoprotein Levels Caused by a Common Cholesteryl-Ester Transfer Protein Gene Mutation | New England Journal of Medicine | 1990 | 802 |
| 41 | Self-injurious thoughts and behaviors as risk factors for future suicide ideation, attempts, and death: a meta-analysis of longitudinal studies | Psychological Medicine | 2016 | 798 |
| 42 | Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease | Science | 2018 | 797 |
| 43 | Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury | Journal of Clinical Investigation | 2005 | 796 |
| 44 | Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes. | Journal of Clinical Investigation | 1995 | 792 |
| 45 | Prevalence of Vitamin D Inadequacy among Postmenopausal North American Women Receiving Osteoporosis Therapy | Journal of Clinical Endocrinology and Metabolism | 2005 | 789 |
| 46 | Magnitude of body-cell-mass depletion and the timing of death from wasting in AIDS | American Journal of Clinical Nutrition | 1989 | 788 |
| 47 | The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages | Nature Cell Biology | 2003 | 780 |
| 48 | Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2020 | 776 |
| 49 | IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. | Journal of Clinical Investigation | 1997 | 772 |
| 50 | A principle for counting tissue structures on random sections | Journal of Applied Physiology | 1962 | 770 |
