| # | Title | Journal | Year | Citations |
|---|
| 1 | Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids | Molecular Pharmacology | 2005 | 459 |
| 2 | Characterization of the Oxidative Metabolites of 17β-Estradiol and Estrone Formed by 15 Selectively Expressed Human Cytochrome P450 Isoforms | Endocrinology | 2003 | 408 |
| 3 | Payment Restrictions for Prescription Drugs under Medicaid | New England Journal of Medicine | 1987 | 400 |
| 4 | Key factors in the rising cost of new drug discovery and development | Nature Reviews Drug Discovery | 2004 | 356 |
| 5 | Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols | Carcinogenesis | 2006 | 333 |
| 6 | Structural insight into substrate and inhibitor discrimination by human P-glycoprotein | Science | 2019 | 330 |
| 7 | Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives | | 1999 | 275 |
| 8 | Patient compliance-an overview | Journal of Clinical Pharmacy and Therapeutics | 1992 | 257 |
| 9 | Squalene: potential chemopreventive agent | Expert Opinion on Investigational Drugs | 2000 | 251 |
| 10 | Effects of purified green and black tea polyphenols on cyclooxygenase- and lipoxygenase-dependent metabolism of arachidonic acid in human colon mucosa and colon tumor tissues11Abbreviations: COX, cyclooxygenase; LOX, lipoxygenase; EGCG, (-)-epigallocatechin-3-gallate; EGC, (-)-epigallocatechin; ECG, (-)-epicatechin-3-gallate; EC, (-)-epicatechin; TF, theaflavin; TF3-G, theaflavin 3-gallate; TF3′-G, theaflavin 3′-gallate; TFdiG, theaflavin 3,3′-digallate; PGE2, prostaglandin E2; HETE, hydroxyeicosatetraenoic | Biochemical Pharmacology | 2001 | 241 |
| 11 | Quantitative Structure-Activity Relationship of Various Endogenous Estrogen Metabolites for Human Estrogen Receptor α and β Subtypes: Insights into the Structural Determinants Favoring a Differential Subtype Binding | Endocrinology | 2006 | 221 |
| 12 | Catechol-O-Methyltransferase (COMT)-Mediated Methylation Metabolism of Endogenous Bioactive Catechols and Modulation by Endobiotics and Xenobiotics: Importance in Pathophysiology and Pathogenesis | Current Drug Metabolism | 2002 | 220 |
| 13 | Designing a broad-spectrum integrative approach for cancer prevention and treatment | Seminars in Cancer Biology | 2015 | 220 |
| 14 | Early-onset colorectal cancer: initial clues and current views | Nature Reviews Gastroenterology and Hepatology | 2020 | 220 |
| 15 | Economic, clinical, and humanistic outcomes: a planning model for pharmacoeconomic research | Clinical Therapeutics | 1993 | 162 |
| 16 | Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro | Journal of Steroid Biochemistry and Molecular Biology | 2007 | 160 |
| 17 | Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1 | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 153 |
| 18 | Systematic Review and Meta-Analysis of Acute Kidney Injury Associated with Concomitant Vancomycin and Piperacillin/tazobactam | Clinical Infectious Diseases | 2017 | 134 |
| 19 | The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities | International Journal of Pharmaceutics | 2001 | 132 |
| 20 | Green tea polyphenol (−)‐epigallocatechin‐3‐gallate inhibits cyclooxygenase‐2 expression in colon carcinogenesis | Molecular Carcinogenesis | 2006 | 128 |
| 21 | Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay | Journal of Lipid Research | 2004 | 126 |
| 22 | Nitric Oxide, a Mediator of Inflammation, Suppresses Tumorigenesis | Cancer Research | 2004 | 124 |
| 23 | The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems | International Journal of Pharmaceutics | 2000 | 121 |
| 24 | Influence of Drug Lipophilicity on Terpenes as Transdermal Penetration Enhancers | Drug Development and Industrial Pharmacy | 1999 | 119 |
| 25 | IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis | Molecular Carcinogenesis | 2017 | 113 |
| 26 | Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7‐hydroxymitragynine | Addiction Biology | 2019 | 103 |
| 27 | Nitric Oxide Is a Key Component in Inflammation-Accelerated Tumorigenesis | Cancer Research | 2008 | 97 |
| 28 | Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery | Nanomedicine | 2010 | 97 |
| 29 | Percutaneous penetration enhancers: local versus transdermal activity | Pharmaceutical Science & Technology Today | 2000 | 95 |
| 30 | The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress | Cancer Research | 2005 | 93 |
| 31 | Mesoporous silica nanoparticles: facile surface functionalization and versatile biomedical applications in oncology | Acta Biomaterialia | 2020 | 90 |
| 32 | Compliance with Antihypertensive Therapy in the Elderly | American Journal of Cardiovascular Drugs | 2008 | 85 |
| 33 | The cost of new drug discovery and development | Discovery Medicine | 2004 | 85 |
| 34 | Experimental Design for the Optimization of Lipid Nanoparticles | Journal of Pharmaceutical Sciences | 2009 | 84 |
| 35 | In vitro and in vivo estrogenic activity of chlorinated derivatives of bisphenol A | Toxicology | 2005 | 79 |
| 36 | STRONG INHIBITORY EFFECTS OF COMMON TEA CATECHINS AND BIOFLAVONOIDS ON THE O-METHYLATION OF CATECHOL ESTROGENS CATALYZED BY HUMAN LIVER CYTOSOLIC CATECHOL-O-METHYLTRANSFERASE | Drug Metabolism and Disposition | 2004 | 76 |
| 37 | Physical Partner Violence and Medicaid Utilization and Expenditures | Public Health Reports | 2004 | 75 |
| 38 | Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐ApcMin/+ mouse model of intestinal cancer | Molecular Carcinogenesis | 2009 | 75 |
| 39 | NADPH-dependent metabolism of 17β-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms | Steroids | 2005 | 73 |
| 40 | Molecular Interaction of the Antagonist N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 Cannabinoid Receptor | Journal of Medicinal Chemistry | 2002 | 72 |
| 41 | Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction | Biopolymers | 2003 | 72 |
| 42 | Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics | International Psychogeriatrics | 2005 | 71 |
| 43 | Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5 | Journal of Pharmacology and Experimental Therapeutics | 2001 | 71 |
| 44 | Emodin reduces Breast Cancer Lung Metastasis by suppressing Macrophage-induced Breast Cancer Cell Epithelial-mesenchymal transition and Cancer Stem Cell formation | Theranostics | 2020 | 70 |
| 45 | Gabapentin for the treatment of ethanol withdrawal | Substance Abuse | 2003 | 68 |
| 46 | Assessment of COVID-19 Information Overload Among the General Public | Journal of Racial and Ethnic Health Disparities | 2022 | 68 |
| 47 | O-Methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase | Drug Metabolism and Disposition | 2000 | 66 |
| 48 | Transdermal Delivery of Drugs with Differing Lipophilicities Using Azone Analogs as Dermal Penetration Enhancers | Journal of Pharmaceutical Sciences | 1995 | 65 |
| 49 | Populations at Risk for Penicillin-Induced Seizures | Annals of Pharmacotherapy | 1992 | 63 |
| 50 | Evaluation of a human bio-engineered skin equivalent for drug permeation studies | Pharmaceutical Research | 2000 | 61 |
