| # | Title | Journal | Year | Citations |
|---|
| 1 | Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms | Pharmacological Research | 2018 | 276 |
| 2 | MicroRNA-140-5p aggravates doxorubicin-induced cardiotoxicity by promoting myocardial oxidative stress via targeting Nrf2 and Sirt2 | Redox Biology | 2018 | 224 |
| 3 | A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases | Frontiers in Pharmacology | 2020 | 163 |
| 4 | Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress | Redox Biology | 2018 | 151 |
| 5 | Current trends in drug metabolism and pharmacokinetics | Acta Pharmaceutica Sinica B | 2019 | 147 |
| 6 | Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway | Pharmacological Research | 2018 | 146 |
| 7 | Temperature-Sensitive Lipid-Coated Carbon Nanotubes for Synergistic Photothermal Therapy and Gene Therapy | ACS Nano | 2021 | 129 |
| 8 | RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer | Biomaterials | 2019 | 127 |
| 9 | A novel paclitaxel-loaded poly(ε-caprolactone)/Poloxamer 188 blend nanoparticle overcoming multidrug resistance for cancer treatment | Acta Biomaterialia | 2010 | 125 |
| 10 | Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo | Toxicology Letters | 2012 | 121 |
| 11 | Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition | Free Radical Biology and Medicine | 2015 | 119 |
| 12 | Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation via its Effects on the Nox4/ROS-NF-κB and MAPK Pathways | Journal of Atherosclerosis and Thrombosis | 2014 | 118 |
| 13 | Therapeutic Versatility of Resveratrol Derivatives | Nutrients | 2017 | 115 |
| 14 | A Novel Docetaxel-Loaded Poly (ε-Caprolactone)/Pluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment | Nanoscale Research Letters | 2009 | 113 |
| 15 | Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation | Toxicology | 2017 | 113 |
| 16 | Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia–reperfusion injury through suppression of apoptosis and inflammation | Neurochemistry International | 2013 | 111 |
| 17 | Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential | Journal of Pineal Research | 2017 | 107 |
| 18 | Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections | Pharmacological Research | 2018 | 105 |
| 19 | Exosome-based nanocarriers as bio-inspired and versatile vehicles for drug delivery: recent advances and challenges | Journal of Materials Chemistry B | 2019 | 105 |
| 20 | Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway | Journal of Experimental and Clinical Cancer Research | 2018 | 101 |
| 21 | miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3 | Theranostics | 2018 | 99 |
| 22 | Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme | Food and Chemical Toxicology | 2013 | 94 |
| 23 | Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway | Scientific Reports | 2016 | 93 |
| 24 | Mechanism investigation of dioscin against CCl 4 -induced acute liver damage in mice | Environmental Toxicology and Pharmacology | 2012 | 92 |
| 25 | Nanoparticles of Poly(Lactide-Co-Glycolide)-d-a-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer for Cancer Treatment | Nanoscale Research Letters | 2010 | 91 |
| 26 | Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice | Food and Chemical Toxicology | 2013 | 89 |
| 27 | Endothelial nitric oxide synthase in the microcirculation | Cellular and Molecular Life Sciences | 2015 | 89 |
| 28 | Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway | Toxicology and Applied Pharmacology | 2016 | 89 |
| 29 | Tannin extracts from immature fruits of Terminalia chebula Fructus Retz. promote cutaneous wound healing in rats | BMC Complementary and Alternative Medicine | 2011 | 84 |
| 30 | Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer | Journal of Medicinal Chemistry | 2016 | 84 |
| 31 | Protective effects of dioscin against cisplatin‐induced nephrotoxicity via the microRNA‐34a/sirtuin 1 signalling pathway | British Journal of Pharmacology | 2017 | 84 |
| 32 | Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine | Phytomedicine | 2008 | 81 |
| 33 | Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats | Food Chemistry | 2013 | 80 |
| 34 | Pharmacokinetic Interactions Between Herbal Medicines and Prescribed Drugs: Focus on Drug Metabolic Enzymes and Transporters | Current Drug Metabolism | 2015 | 80 |
| 35 | Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway | Food and Chemical Toxicology | 2013 | 79 |
| 36 | Potent effects of dioscin against liver fibrosis | Scientific Reports | 2015 | 79 |
| 37 | Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway | Pharmacological Research | 2018 | 79 |
| 38 | Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy | Pharmacological Research | 2019 | 78 |
| 39 | Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway | Cancer Biology and Therapy | 2015 | 76 |
| 40 | Potent effects of dioscin against obesity in mice | Scientific Reports | 2015 | 75 |
| 41 | Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation | Toxicology Letters | 2018 | 75 |
| 42 | Dioscin Attenuates Hepatic Ischemia-Reperfusion Injury in Rats Through Inhibition of Oxidative-Nitrative Stress, Inflammation and Apoptosis | Transplantation | 2014 | 72 |
| 43 | Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells | International Journal of Nanomedicine | 2014 | 72 |
| 44 | Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70 | Pharmacological Research | 2015 | 72 |
| 45 | Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway | International Immunopharmacology | 2016 | 72 |
| 46 | Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway | Pharmacological Research | 2016 | 71 |
| 47 | Protective effects of dioscin against alcohol-induced liver injury | Archives of Toxicology | 2014 | 70 |
| 48 | MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1 | Pharmacological Research | 2019 | 69 |
| 49 | Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells | Molecular Cancer | 2014 | 68 |
| 50 | Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis | Toxicology and Applied Pharmacology | 2015 | 66 |
