| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES | Annual Review of Cell and Developmental Biology | 1998 | 2,759 |
| 3 | Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation | Molecular Cell | 2000 | 1,219 |
| 4 | Evolution of pathogenicity and sexual reproduction in eight Candida genomes | Nature | 2009 | 963 |
| 5 | Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils | Nature Structural and Molecular Biology | 2010 | 956 |
| 6 | Structure and Origin of Ordered Lipid Domains in Biological Membranes | Journal of Membrane Biology | 1998 | 900 |
| 7 | Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior. | Proceedings of the National Academy of Sciences of the United States of America | 1994 | 691 |
| 8 | Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist | Biochemical Pharmacology | 1993 | 653 |
| 9 | DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1 | Nature | 2004 | 641 |
| 10 | The two-hybrid system: an assay for protein-protein interactions | Trends in Genetics | 1994 | 630 |
| 11 | Insolubility of lipids in Triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts) | Biochimica Et Biophysica Acta - Biomembranes | 2000 | 591 |
| 12 | Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts | Journal of Biological Chemistry | 1999 | 583 |
| 13 | Structure of Detergent-Resistant Membrane Domains: Does Phase Separation Occur in Biological Membranes? | Biochemical and Biophysical Research Communications | 1997 | 489 |
| 14 | Effect of the Structure of Natural Sterols and Sphingolipids on the Formation of Ordered Sphingolipid/Sterol Domains (Rafts) | Journal of Biological Chemistry | 2001 | 472 |
| 15 | Perinuclear localization of chromatin facilitates transcriptional silencing | Nature | 1998 | 433 |
| 16 | Advancing Crop Transformation in the Era of Genome Editing | Plant Cell | 2016 | 429 |
| 17 | Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms | Science | 2018 | 420 |
| 18 | Regulation of ion channel localization and phosphorylation by neuronal activity | Nature Neuroscience | 2004 | 407 |
| 19 | Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals | Physiology | 2006 | 400 |
| 20 | Compact Myelin Dictates the Differential Targeting of Two Sodium Channel Isoforms in the Same Axon | Neuron | 2001 | 373 |
| 21 | The Crystal Structure of Yeast Protein Disulfide Isomerase Suggests Cooperativity between Its Active Sites | Cell | 2006 | 346 |
| 22 | Deciphering Protein Kinase Specificity Through Large-Scale Analysis of Yeast Phosphorylation Site Motifs | Science Signaling | 2010 | 341 |
| 23 | The runt domain identifies a new family of heterometric transcriptional regulators | Trends in Genetics | 1993 | 339 |
| 24 | Sporulation in the Budding Yeast Saccharomyces cerevisiae | Genetics | 2011 | 324 |
| 25 | WIF1, a component of the Wnt pathway, is down‐regulated in prostate, breast, lung, and bladder cancer | Journal of Pathology | 2003 | 313 |
| 26 | Electrostatic Sequestration of PIP2 on Phospholipid Membranes by Basic/Aromatic Regions of Proteins | Biophysical Journal | 2004 | 285 |
| 27 | Biological functions of fucose in mammals | Glycobiology | 2017 | 282 |
| 28 | Helix Packing in Polytopic Membrane Proteins: Role of Glycine in Transmembrane Helix Association | Biophysical Journal | 1999 | 274 |
| 29 | Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling | Cell | 2008 | 272 |
| 30 | Evidence against the presence of an anandamide transporter | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 270 |
| 31 | DNA-replication checkpoint control at the Drosophila midblastula transition | Nature | 1997 | 264 |
| 32 | NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs | Oncogene | 2007 | 259 |
| 33 | Insights into lipid raft structure and formation from experiments in model membranes | Current Opinion in Structural Biology | 2002 | 252 |
| 34 | Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover | Journal of Lipid Research | 2007 | 252 |
| 35 | Biology of callose (β-1,3-glucan) turnover at plasmodesmata | Protoplasma | 2011 | 252 |
| 36 | Simple and efficient CRISPR/Cas9‐mediated targeted mutagenesis in Xenopus tropicalis | Genesis | 2013 | 251 |
| 37 | Groucho-Dependent and -Independent Repression Activities of Runt Domain Proteins | Molecular and Cellular Biology | 1997 | 242 |
| 38 | Fatty acid amide hydrolase is located preferentially in large neurons in the rat central nervous system as revealed by immunohistochemistry | Neuroscience Letters | 1998 | 238 |
| 39 | Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity | Science | 2017 | 232 |
| 40 | Partner Choice during Meiosis Is Regulated by Hop1-promoted Dimerization of Mek1 | Molecular Biology of the Cell | 2005 | 231 |
| 41 | Accumulation of Caveolin in the Endoplasmic Reticulum Redirects the Protein to Lipid Storage Droplets | Journal of Cell Biology | 2001 | 230 |
| 42 | Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look | Journal of Ethnopharmacology | 2000 | 227 |
| 43 | Four-jointed Is a Golgi Kinase That Phosphorylates a Subset of Cadherin Domains | Science | 2008 | 226 |
| 44 | How principles of domain formation in model membranes may explain ambiguities concerning lipid raft formation in cells | Biochimica Et Biophysica Acta - Molecular Cell Research | 2005 | 223 |
| 45 | The essential function of yeast protein disulfide isomerase does not reside in its isomerase activity | Cell | 1993 | 221 |
| 46 | The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions | Genes and Development | 2004 | 221 |
| 47 | The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima | PLoS Biology | 2014 | 221 |
| 48 | The Cdk-Activating Kinase (CAK) from Budding Yeast | Cell | 1996 | 219 |
| 49 | Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase | Biochemical Pharmacology | 1997 | 214 |
| 50 | Structural Insights into E1-Catalyzed Ubiquitin Activation and Transfer to Conjugating Enzymes | Cell | 2008 | 214 |
