| # | Title | Journal | Year | Citations |
|---|
| 1 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 2 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 3 | Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials | Lancet Respiratory Medicine,the | 2015 | 937 |
| 4 | Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study | Gastroenterology | 2021 | 913 |
| 5 | Tuberculosis | Nature Reviews Disease Primers | 2016 | 830 |
| 6 | Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial | Lancet, The | 2010 | 813 |
| 7 | The burden of non-communicable diseases in South Africa | Lancet, The | 2009 | 748 |
| 8 | Controversies in ventricular remodelling | Lancet, The | 2006 | 742 |
| 9 | Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings | Lancet Infectious Diseases, The | 2008 | 681 |
| 10 | Tuberculous meningitis: a uniform case definition for use in clinical research | Lancet Infectious Diseases, The | 2010 | 659 |
| 11 | Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies | International Journal of Epidemiology | 2019 | 643 |
| 12 | Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study | Lancet, The | 2013 | 624 |
| 13 | HIV infection: epidemiology, pathogenesis, treatment, and prevention | Lancet, The | 2014 | 616 |
| 14 | Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2015 | 609 |
| 15 | Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance | JAMA - Journal of the American Medical Association | 2018 | 538 |
| 16 | A controlled double blind study of azathioprine in the management of Crohn's disease. | Gut | 1995 | 528 |
| 17 | Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa | Aids | 2004 | 475 |
| 18 | The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis | Lancet Respiratory Medicine,the | 2017 | 459 |
| 19 | Evaluation of Bromocriptine in the Treatment of Acute Severe Peripartum Cardiomyopathy | Circulation | 2010 | 429 |
| 20 | In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa | Journal of Ethnopharmacology | 2004 | 418 |
| 21 | Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism | EMBO Molecular Medicine | 2010 | 417 |
| 22 | Risk Factors for Coronavirus Disease 2019 (COVID-19) Death in a Population Cohort Study from the Western Cape Province, South Africa | Clinical Infectious Diseases | 2021 | 405 |
| 23 | Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials | Lancet Respiratory Medicine,the | 2016 | 398 |
| 24 | Health in South Africa: changes and challenges since 2009 | Lancet, The | 2012 | 396 |
| 25 | ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia | European Heart Journal | 2015 | 395 |
| 26 | Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study) | European Heart Journal | 2015 | 391 |
| 27 | Tuberculous Pericarditis | Circulation | 2005 | 389 |
| 28 | EFFECTS OF FEEDING DIFFERENT FATS ON SERUM-CHOLESTEROL LEVEL | Lancet, The | 1956 | 383 |
| 29 | Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial | Lancet, The | 2014 | 379 |
| 30 | Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes | Journal of Infectious Diseases | 2013 | 378 |
| 31 | Acute rheumatic fever and rheumatic heart disease | Nature Reviews Disease Primers | 2016 | 371 |
| 32 | Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission | The Lancet Gastroenterology and Hepatology | 2019 | 370 |
| 33 | The international WAO/EAACI guideline for the management of hereditary angioedema—The 2017 revision and update | Allergy: European Journal of Allergy and Clinical Immunology | 2018 | 365 |
| 34 | Limitation of life support: Frequency and practice in a London and a Cape Town intensive care unit | Intensive Care Medicine | 1996 | 344 |
| 35 | Efficacy and safety of alirocumab in high cardiovascular risk patients with inadequately controlled hypercholesterolaemia on maximally tolerated doses of statins: the ODYSSEY COMBO II randomized controlled trial | European Heart Journal | 2015 | 344 |
| 36 | Health and Health Care in South Africa — 20 Years after Mandela | New England Journal of Medicine | 2014 | 338 |
| 37 | Development of a Standardized Screening Rule for Tuberculosis in People Living with HIV in Resource-Constrained Settings: Individual Participant Data Meta-analysis of Observational Studies | PLoS Medicine | 2011 | 328 |
| 38 | Diabetes in sub-Saharan Africa: from clinical care to health policy | Lancet Diabetes and Endocrinology,the | 2017 | 328 |
| 39 | The Lancet Commission on diabetes: using data to transform diabetes care and patient lives | Lancet, The | 2020 | 327 |
| 40 | Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome | Aids | 2010 | 323 |
| 41 | Antibiotic stewardship in low- and middle-income countries: the same but different? | Clinical Microbiology and Infection | 2017 | 323 |
| 42 | Global tuberculosis drug development pipeline: the need and the reality | Lancet, The | 2010 | 319 |
| 43 | Reduction in Lipoprotein(a) With PCSK9 Monoclonal Antibody Evolocumab (AMG 145) | Journal of the American College of Cardiology | 2014 | 316 |
| 44 | Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction | American Journal of Cardiology | 1975 | 314 |
| 45 | Detection of Tuberculosis in HIV-Infected and -Uninfected African Adults Using Whole Blood RNA Expression Signatures: A Case-Control Study | PLoS Medicine | 2013 | 314 |
| 46 | Functional Capacity of Mycobacterium tuberculosis-Specific T Cell Responses in Humans Is Associated with Mycobacterial Load | Journal of Immunology | 2011 | 305 |
| 47 | The red wine hypothesis: from concepts to protective signalling molecules | European Heart Journal | 2007 | 304 |
| 48 | Determinants of Mortality in a Combined Cohort of 501 Patients With HIV-Associated Cryptococcal Meningitis: Implications for Improving Outcomes | Clinical Infectious Diseases | 2014 | 299 |
| 49 | Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study | Lancet Infectious Diseases, The | 2011 | 294 |
| 50 | Hepatitis C | Lancet, The | 2019 | 285 |
