| # | Title | Journal | Year | Citations |
|---|
| 1 | GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours | Nature | 1989 | 1,680 |
| 2 | Two G protein oncogenes in human endocrine tumors | Science | 1990 | 1,039 |
| 3 | Opioids and the Management of Chronic Severe Pain in the Elderly: Consensus Statement of an International Expert Panel with Focus on the Six Clinically Most Often Used World Health Organization step III Opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone) | Pain Practice | 2008 | 710 |
| 4 | Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain | Development (Cambridge) | 2004 | 587 |
| 5 | Neuroendocrine Control of Growth Hormone Secretion | Physiological Reviews | 1999 | 571 |
| 6 | Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas | Nature | 1987 | 510 |
| 7 | The endoplasmic reticulum Ca2+ store: a view from the lumen | Trends in Biochemical Sciences | 1998 | 494 |
| 8 | Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice | Cell Metabolism | 2010 | 467 |
| 9 | Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons | Nature | 1989 | 447 |
| 10 | The granin-(chromogranin/secretogranin) family | Trends in Biochemical Sciences | 1991 | 434 |
| 11 | Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells. | Journal of Cell Biology | 1987 | 427 |
| 12 | The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. | Journal of Cell Biology | 1990 | 370 |
| 13 | Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism | Biological Psychiatry | 2011 | 315 |
| 14 | Extracellular Interactions between GluR2 and N-Cadherin in Spine Regulation | Neuron | 2007 | 313 |
| 15 | The dynamic role of palmitoylation in signal transduction | Trends in Biochemical Sciences | 1995 | 312 |
| 16 | The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury | Free Radical Biology and Medicine | 1999 | 312 |
| 17 | Chronic Δ9-Tetrahydrocannabinol During Adolescence Provokes Sex-Dependent Changes in the Emotional Profile in Adult Rats: Behavioral and Biochemical Correlates | Neuropsychopharmacology | 2008 | 304 |
| 18 | The Effects of Tramadol and Morphine on Immune Responses and Pain After Surgery in Cancer Patients | Anesthesia and Analgesia | 2000 | 303 |
| 19 | Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative | Free Radical Biology and Medicine | 2007 | 301 |
| 20 | Post-transcriptional regulation of gene expression by degradation of messenger RNAs | Journal of Cellular Physiology | 2003 | 294 |
| 21 | Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2 | Nature | 2003 | 285 |
| 22 | The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain | European Journal of Pharmacology | 2007 | 285 |
| 23 | αvβ3 and αvβ5 Integrin Expression in Glioma Periphery | Neurosurgery | 2001 | 280 |
| 24 | TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents | Journal of Clinical Investigation | 2006 | 265 |
| 25 | Pharmacology of Silymarin | Clinical Drug Investigation | 2002 | 259 |
| 26 | The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB1, TRPV1 and PPARγ receptors and neurotrophic factors | Pain | 2008 | 254 |
| 27 | Expression of a ryanodine receptor-Ca2+ channel that is regulated by TGF-beta | Science | 1992 | 252 |
| 28 | Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood | Hippocampus | 2009 | 244 |
| 29 | Current Knowledge of Buprenorphine and Its Unique Pharmacological Profile | Pain Practice | 2010 | 244 |
| 30 | Nitric oxide and mitochondrial biogenesis | Journal of Cell Science | 2006 | 243 |
| 31 | Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation | Nature Neuroscience | 2008 | 233 |
| 32 | Inhibition of Dendritic Spine Morphogenesis and Synaptic Transmission by Activity-Inducible Protein Homer1a | Journal of Neuroscience | 2003 | 232 |
| 33 | Platelets as a model for neurones? | Experientia | 1988 | 228 |
| 34 | Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines | Journal of Pharmacology and Experimental Therapeutics | 2004 | 225 |
| 35 | Mutation withinTARDBPleads to Frontotemporal Dementia without motor neuron disease | Human Mutation | 2009 | 220 |
| 36 | Defective Mitochondrial Biogenesis | Circulation Research | 2007 | 219 |
| 37 | Clinical Pharmacokinetics of Atypical Antipsychotics | Clinical Pharmacokinetics | 2007 | 217 |
| 38 | Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation | British Journal of Pharmacology | 2004 | 214 |
| 39 | mTOR: a protein kinase switching between life and death | Pharmacological Research | 2004 | 209 |
| 40 | Opioids and the immune system | Palliative Medicine | 2006 | 208 |
| 41 | Clioquinol: Review of its Mechanisms of Action and Clinical Uses in Neurodegenerative Disorders | CNS Neuroscience and Therapeutics | 2012 | 196 |
| 42 | CB1 Signaling in Forebrain and Sympathetic Neurons Is a Key Determinant of Endocannabinoid Actions on Energy Balance | Cell Metabolism | 2010 | 190 |
| 43 | A Preformed Complex of Postsynaptic Proteins Is Involved in Excitatory Synapse Development | Neuron | 2006 | 188 |
| 44 | Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease | Journal of Pineal Research | 2005 | 187 |
| 45 | Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses | Journal of Biological Chemistry | 2011 | 180 |
| 46 | Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells | Biochemical and Biophysical Research Communications | 1985 | 176 |
| 47 | Antinociceptive and immunosuppressive effects of opiate drugs: a structure-related activity study | British Journal of Pharmacology | 1997 | 176 |
| 48 | Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells | Journal of Biological Chemistry | 1990 | 176 |
| 49 | Ca2+ influx following receptor activation | Trends in Pharmacological Sciences | 1991 | 175 |
| 50 | The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders | Expert Opinion on Drug Metabolism and Toxicology | 2007 | 173 |
