| # | Title | Journal | Year | Citations |
|---|
| 1 | World Health Organization 2020 guidelines on physical activity and sedentary behaviour | British Journal of Sports Medicine | 2020 | 4,050 |
| 2 | Defining trained immunity and its role in health and disease | Nature Reviews Immunology | 2020 | 1,345 |
| 3 | Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa | Nature | 2022 | 1,210 |
| 4 | The spectrum of latent tuberculosis: rethinking the biology and intervention strategies | Nature Reviews Microbiology | 2009 | 1,179 |
| 5 | A flexible R package for nonnegative matrix factorization | BMC Bioinformatics | 2010 | 1,074 |
| 6 | Dectin-1: a signalling non-TLR pattern-recognition receptor | Nature Reviews Immunology | 2006 | 982 |
| 7 | Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization | Nature | 2022 | 928 |
| 8 | Controversies in ventricular remodelling | Lancet, The | 2006 | 742 |
| 9 | Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery | International Journal of Molecular Sciences | 2018 | 703 |
| 10 | Gonadotropin-Releasing Hormone Receptors | Endocrine Reviews | 2004 | 698 |
| 11 | Tuberculosis | Lancet, The | 2011 | 670 |
| 12 | Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 609 |
| 13 | Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders | Pediatrics | 2016 | 561 |
| 14 | Genome-wide association studies | Nature Reviews Methods Primers | 2021 | 529 |
| 15 | A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation | Nature Genetics | 2009 | 528 |
| 16 | Burden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017 | The Lancet Global Health | 2019 | 509 |
| 17 | Scaling up physical activity interventions worldwide: stepping up to larger and smarter approaches to get people moving | Lancet, The | 2016 | 508 |
| 18 | Infertility and the provision of infertility medical services in developing countries | Human Reproduction Update | 2008 | 499 |
| 19 | Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013 | JAMA Pediatrics | 2016 | 479 |
| 20 | Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis | Lancet, The | 2018 | 452 |
| 21 | Understanding COVID-19 vaccine hesitancy | Nature Medicine | 2021 | 434 |
| 22 | Evaluation of Bromocriptine in the Treatment of Acute Severe Peripartum Cardiomyopathy | Circulation | 2010 | 429 |
| 23 | Central role of PPARα-dependent hepatic lipid turnover in dietary steatohepatitis in mice | Hepatology | 2003 | 420 |
| 24 | Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism | EMBO Molecular Medicine | 2010 | 417 |
| 25 | Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database | Nature Genetics | 2014 | 410 |
| 26 | Perioperative patient outcomes in the African Surgical Outcomes Study: a 7-day prospective observational cohort study | Lancet, The | 2018 | 373 |
| 27 | Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations inABCC6 | Human Mutation | 2005 | 365 |
| 28 | Quantitating the Multiplicity of Infection with Human Immunodeficiency Virus Type 1 Subtype C Reveals a Non-Poisson Distribution of Transmitted Variants | Journal of Virology | 2009 | 354 |
| 29 | Immune recognition of fungal β-glucans | Cellular Microbiology | 2005 | 337 |
| 30 | Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome | Aids | 2010 | 323 |
| 31 | The red wine hypothesis: from concepts to protective signalling molecules | European Heart Journal | 2007 | 304 |
| 32 | Autonomic Control of Heart Rate during and after Exercise | Sports Medicine | 2008 | 304 |
| 33 | The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer | International Journal of Molecular Sciences | 2017 | 301 |
| 34 | Reflections and recommendations on research ethics in developing countries | Social Science and Medicine | 2002 | 295 |
| 35 | Tuberculosis among HIV-infected patients receiving HAART: long term incidence and risk factors in a South African cohort | Aids | 2005 | 294 |
| 36 | Short-term and long-term risk of tuberculosis associated with CD4 cell recovery during antiretroviral therapy in South Africa | Aids | 2009 | 289 |
| 37 | Hepatitis C | Lancet, The | 2019 | 285 |
| 38 | Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology | Cardiovascular Research | 2018 | 284 |
| 39 | Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa | Aids | 2007 | 280 |
| 40 | Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart | Cardiovascular Research | 2017 | 278 |
| 41 | Trained immunity, tolerance, priming and differentiation: distinct immunological processes | Nature Immunology | 2021 | 274 |
| 42 | Male circumcision for prevention of heterosexual acquisition of HIV in men | The Cochrane Library | 2009 | 273 |
| 43 | Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study | Lancet Infectious Diseases, The | 2012 | 268 |
| 44 | Phenotyping and outcome on contemporary management in a German cohort of patients with peripartum cardiomyopathy | Basic Research in Cardiology | 2013 | 266 |
| 45 | High Responders and Low Responders: Factors Associated with Individual Variation in Response to Standardized Training | Sports Medicine | 2014 | 266 |
| 46 | The International Study of Childhood Obesity, Lifestyle and the Environment (ISCOLE): design and methods | BMC Public Health | 2013 | 264 |
| 47 | Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials | Lancet, The | 2017 | 263 |
| 48 | Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery | Basic Research in Cardiology | 2016 | 257 |
| 49 | The COL5A1 gene and Achilles tendon pathology | Scandinavian Journal of Medicine and Science in Sports | 2006 | 252 |
| 50 | Screening for HIV-Associated Tuberculosis and Rifampicin Resistance before Antiretroviral Therapy Using the Xpert MTB/RIF Assay: A Prospective Study | PLoS Medicine | 2011 | 251 |
