| # | Title | Journal | Year | Citations |
|---|
| 1 | Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy | JAMA - Journal of the American Medical Association | 2020 | 1,777 |
| 2 | Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy | JAMA Internal Medicine | 2020 | 1,165 |
| 3 | Hypercoagulability of COVID‐19 patients in intensive care unit: A report of thromboelastography findings and other parameters of hemostasis | Journal of Thrombosis and Haemostasis | 2020 | 1,070 |
| 4 | Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease | Nature Genetics | 2017 | 783 |
| 5 | Genetics and epigenetics of NAFLD and NASH: Clinical impact | Journal of Hepatology | 2018 | 670 |
| 6 | Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration | 2017 | 607 |
| 7 | Factors Influencing Children’s Eating Behaviours | Nutrients | 2018 | 588 |
| 8 | Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0© | Neurogastroenterology and Motility | 2021 | 468 |
| 9 | The Application of Esophageal Pressure Measurement in Patients with Respiratory Failure | American Journal of Respiratory and Critical Care Medicine | 2014 | 443 |
| 10 | Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease | Hepatology | 2015 | 424 |
| 11 | Pulmonary fibrosis secondary to COVID-19: a call to arms? | Lancet Respiratory Medicine,the | 2020 | 404 |
| 12 | Physiologic Effects of High-Flow Nasal Cannula in Acute Hypoxemic Respiratory Failure | American Journal of Respiratory and Critical Care Medicine | 2017 | 390 |
| 13 | The past and future of haemophilia: diagnosis, treatments, and its complications | Lancet, The | 2016 | 331 |
| 14 | Advancing the global public health agenda for NAFLD: a consensus statement | Nature Reviews Gastroenterology and Hepatology | 2022 | 330 |
| 15 | Heated Humidified High-Flow Nasal Oxygen in Adults | Chest | 2015 | 317 |
| 16 | Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates | Journal of the European Academy of Dermatology and Venereology | 2018 | 308 |
| 17 | PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells | Human Molecular Genetics | 2014 | 293 |
| 18 | Traumatic Intracranial Hypertension | New England Journal of Medicine | 2014 | 286 |
| 19 | Analysis of SARS-CoV-2 vertical transmission during pregnancy | Nature Communications | 2020 | 284 |
| 20 | Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries | BMJ, The | 2021 | 281 |
| 21 | Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆ | Journal of Hepatology | 2020 | 279 |
| 22 | Physiological functions and pathobiology of TDP‐43 and FUS/TLS proteins | Journal of Neurochemistry | 2016 | 278 |
| 23 | Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status | Acta Neuropathologica | 2016 | 262 |
| 24 | Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver | Journal of Internal Medicine | 2018 | 256 |
| 25 | COVID‐19 and liver disease | Liver International | 2020 | 252 |
| 26 | Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study | Multiple Sclerosis Journal | 2015 | 249 |
| 27 | Rare bleeding disorders: diagnosis and treatment | Blood | 2015 | 244 |
| 28 | Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Updated August 2018 | Endoscopy | 2019 | 241 |
| 29 | Long-term consequences of COVID-19: research needs | Lancet Infectious Diseases, The | 2020 | 241 |
| 30 | Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved? | Lancet Neurology, The | 2014 | 240 |
| 31 | Future trends in cystic fibrosis demography in 34 European countries | European Respiratory Journal | 2015 | 238 |
| 32 | Hospital-Acquired Infections in Critically Ill Patients With COVID-19 | Chest | 2021 | 225 |
| 33 | TREM2 regulates microglial cell activation in response to demyelination in vivo | Acta Neuropathologica | 2015 | 224 |
| 34 | Which individuals are at increased risk of pneumococcal disease and why? Impact of COPD, asthma, smoking, diabetes, and/or chronic heart disease on community-acquired pneumonia and invasive pneumococcal disease: Table 1 | Thorax | 2015 | 224 |
| 35 | Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology | Nature Genetics | 2021 | 223 |
| 36 | Management of bronchiectasis in adults | European Respiratory Journal | 2015 | 220 |
| 37 | Characterization of the “Frequent Exacerbator Phenotype” in Bronchiectasis | American Journal of Respiratory and Critical Care Medicine | 2018 | 215 |
| 38 | The involvement of microRNAs in neurodegenerative diseases | Frontiers in Cellular Neuroscience | 2013 | 209 |
| 39 | Congenital Hypothyroidism: A 2020–2021 Consensus Guidelines Update—An ENDO-European Reference Network Initiative Endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology | Thyroid | 2021 | 209 |
| 40 | UV-C irradiation is highly effective in inactivating SARS-CoV-2 replication | Scientific Reports | 2021 | 207 |
| 41 | Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer | Proceedings of the National Academy of Sciences of the United States of America | 2019 | 198 |
| 42 | Consensus guidelines for lumbar puncture in patients with neurological diseases | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring | 2017 | 197 |
| 43 | MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals | Scientific Reports | 2017 | 193 |
| 44 | Circulating miRNAs as Potential Biomarkers in Alzheimer's Disease | Journal of Alzheimer's Disease | 2014 | 188 |
| 45 | Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial | Lancet Infectious Diseases, The | 2013 | 187 |
| 46 | GBA, Gaucher Disease, and Parkinson’s Disease: From Genetic to Clinic to New Therapeutic Approaches | Cells | 2019 | 187 |
| 47 | The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline | Intensive Care Medicine | 2020 | 185 |
| 48 | Genetic Correction of Human Induced Pluripotent Stem Cells from Patients with Spinal Muscular Atrophy | Science Translational Medicine | 2012 | 180 |
| 49 | Optimum support by high-flow nasal cannula in acute hypoxemic respiratory failure: effects of increasing flow rates | Intensive Care Medicine | 2017 | 180 |
| 50 | Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study | Alzheimer's and Dementia | 2016 | 179 |
