753(top 1%)
papers
27.2K(top 1%)
citations
82(top 1%)
h-index
131(top 1%)
g-index
797
all documents
28.6K
doc citations
3.5K
citing journals

Top Articles

#TitleJournalYearCitations
1Mechanisms of HepatotoxicityToxicological Sciences20021,043
2Mechanisms of Acetaminophen-Induced Liver NecrosisHandbook of Experimental Pharmacology2010775
3Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioningAmerican Journal of Physiology - Renal Physiology2003734
4Mode of Cell Death after Acetaminophen Overdose in Mice: Apoptosis or Oncotic Necrosis?Toxicological Sciences2002366
5Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis?Hepatology2001346
6Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen speciesHepatology1999311
7Reactive oxygen and mechanisms of inflammatory liver injuryJournal of Gastroenterology and Hepatology (Australia)2000298
8Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral SclerosisJournal of Biological Chemistry2004296
9Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated miceHepatology2003290
10A randomized study of solriamfetol for excessive sleepiness in narcolepsyAnnals of Neurology2019274
11Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse HepatocytesJournal of Pharmacology and Experimental Therapeutics2005273
12Bioactivation of leukotoxins to their toxic diols by epoxide hydrolaseNature Medicine1997268
13Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability TransitionDrug Metabolism Reviews2004260
14Vascular and Hepatocellular Peroxynitrite Formation during Acetaminophen Toxicity: Role of Mitochondrial Oxidant StressToxicological Sciences2001254
15Peroxynitrite Is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by GlutathioneJournal of Pharmacology and Experimental Therapeutics2002241
16Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: Mechanism underlying greater toxicity?Life Sciences2014236
17Delay Discounting, Locus of Control, and Cognitive Impulsiveness Independently Predict Tobacco Dependence Treatment Outcomes in a Highly Dependent, Lower Socioeconomic Group of SmokersAmerican Journal on Addictions2012219
18Nitrotyrosine−Protein Adducts in Hepatic Centrilobular Areas following Toxic Doses of Acetaminophen in MiceChemical Research in Toxicology1998203
19Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and ActivityPLoS ONE2011192
20Phospholipase A(2)s in cell injury and deathJournal of Pharmacology and Experimental Therapeutics2000184
21PATHOBIOLOGY OF LIPOPOLYSACCHARIDEJournal of Toxicology and Environmental Health - Part A: Current Issues1997181
22The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onsetJournal of Neurochemistry2006180
23Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonancesScientific Reports2014172
24Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosisNeurobiology of Disease2006165
25Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injuryKidney International2012165
26Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutantsAging2011154
27Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injuryAmerican Journal of Physiology - Renal Physiology2014149
28Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activityBiochemical Pharmacology2012143
29Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human UrineAnalytical Chemistry2011138
30Association Between Sulfotransferase 1A1 Genotype and Survival of Breast Cancer Patients Receiving Tamoxifen TherapyJournal of the National Cancer Institute2002137
31Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney InjuryAmerican Journal of Pathology2012136
32In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor ActivityNeuropsychopharmacology2013136
33Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic InjuryAmerican Journal of Pathology2013134
34Neutrophil-mediated tissue injury in alcoholic hepatitisAlcohol2002133
35Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouseToxicology and Applied Pharmacology2004133
36Acetaminophen Toxicity in Mice Lacking NADPH Oxidase Activity: Role of Peroxynitrite Formation and Mitochondrial Oxidant StressFree Radical Research2003131
37Manganese porphyrin given at symptom onset markedly extends survival of ALS miceAnnals of Neurology2005131
38Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to riskMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis2002126
39Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculatureAmerican Journal of Physiology - Renal Physiology2001124
40Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 ReceptorsJournal of Pharmacology and Experimental Therapeutics2005124
41Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implicationsVascular Pharmacology2006122
42Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP SignalingJournal of Nutrition2009122
43Immunotherapy for the treatment of drug abuseJournal of Nutrition2005121
44Protection against Fas Receptor-Mediated Apoptosis in Hepatocytes and Nonparenchymal Cells by a Caspase-8 Inhibitor in Vivo: Evidence for a Postmitochondrial Processing of Caspase-8Toxicological Sciences2000116
45Evidence for the Role of Reactive Nitrogen Species in Polymicrobial Sepsis-Induced Renal Peritubular Capillary Dysfunction and Tubular InjuryJournal of the American Society of Nephrology: JASN2007116
46Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse?Molecular Interventions: Pharmacological Perspectives From Biology, Chemistry and Genomics2011116
47Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysineJournal of Pharmacology and Experimental Therapeutics2000113
48Manganese-induced reactive oxygen species: Comparison between Mn+2 and Mn+3Experimental Neurology1995111
49Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in MiceJournal of Pharmacology and Experimental Therapeutics2003111
50Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in miceAmerican Journal of Physiology - Renal Physiology2007111