# | Title | Journal | Year | Citations |
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1 | Mechanisms of Hepatotoxicity | Toxicological Sciences | 2002 | 1,043 |
2 | Mechanisms of Acetaminophen-Induced Liver Necrosis | Handbook of Experimental Pharmacology | 2010 | 775 |
3 | Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning | American Journal of Physiology - Renal Physiology | 2003 | 734 |
4 | Mode of Cell Death after Acetaminophen Overdose in Mice: Apoptosis or Oncotic Necrosis? | Toxicological Sciences | 2002 | 366 |
5 | Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: Apoptosis or necrosis? | Hepatology | 2001 | 346 |
6 | Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species | Hepatology | 1999 | 311 |
7 | Reactive oxygen and mechanisms of inflammatory liver injury | Journal of Gastroenterology and Hepatology (Australia) | 2000 | 298 |
8 | Monomeric Cu,Zn-superoxide Dismutase Is a Common Misfolding Intermediate in the Oxidation Models of Sporadic and Familial Amyotrophic Lateral Sclerosis | Journal of Biological Chemistry | 2004 | 296 |
9 | Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice | Hepatology | 2003 | 290 |
10 | A randomized study of solriamfetol for excessive sleepiness in narcolepsy | Annals of Neurology | 2019 | 274 |
11 | Mechanisms of Acetaminophen-Induced Hepatotoxicity: Role of Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes | Journal of Pharmacology and Experimental Therapeutics | 2005 | 273 |
12 | Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase | Nature Medicine | 1997 | 268 |
13 | Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition | Drug Metabolism Reviews | 2004 | 260 |
14 | Vascular and Hepatocellular Peroxynitrite Formation during Acetaminophen Toxicity: Role of Mitochondrial Oxidant Stress | Toxicological Sciences | 2001 | 254 |
15 | Peroxynitrite Is a Critical Mediator of Acetaminophen Hepatotoxicity in Murine Livers: Protection by Glutathione | Journal of Pharmacology and Experimental Therapeutics | 2002 | 241 |
16 | Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ9-THC: Mechanism underlying greater toxicity? | Life Sciences | 2014 | 236 |
17 | Delay Discounting, Locus of Control, and Cognitive Impulsiveness Independently Predict Tobacco Dependence Treatment Outcomes in a Highly Dependent, Lower Socioeconomic Group of Smokers | American Journal on Addictions | 2012 | 219 |
18 | Nitrotyrosine−Protein Adducts in Hepatic Centrilobular Areas following Toxic Doses of Acetaminophen in Mice | Chemical Research in Toxicology | 1998 | 203 |
19 | Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity | PLoS ONE | 2011 | 192 |
20 | Phospholipase A(2)s in cell injury and death | Journal of Pharmacology and Experimental Therapeutics | 2000 | 184 |
21 | PATHOBIOLOGY OF LIPOPOLYSACCHARIDE | Journal of Toxicology and Environmental Health - Part A: Current Issues | 1997 | 181 |
22 | The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset | Journal of Neurochemistry | 2006 | 180 |
23 | Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances | Scientific Reports | 2014 | 172 |
24 | Additive neuroprotective effects of a histone deacetylase inhibitor and a catalytic antioxidant in a transgenic mouse model of amyotrophic lateral sclerosis | Neurobiology of Disease | 2006 | 165 |
25 | Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury | Kidney International | 2012 | 165 |
26 | Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants | Aging | 2011 | 154 |
27 | Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: mitochondria-targeted antioxidant mitigates injury | American Journal of Physiology - Renal Physiology | 2014 | 149 |
28 | Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity | Biochemical Pharmacology | 2012 | 143 |
29 | Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine | Analytical Chemistry | 2011 | 138 |
30 | Association Between Sulfotransferase 1A1 Genotype and Survival of Breast Cancer Patients Receiving Tamoxifen Therapy | Journal of the National Cancer Institute | 2002 | 137 |
31 | Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury | American Journal of Pathology | 2012 | 136 |
32 | In vivo Effects of Abused ‘Bath Salt’ Constituent 3,4-methylenedioxypyrovalerone (MDPV) in Mice: Drug Discrimination, Thermoregulation, and Locomotor Activity | Neuropsychopharmacology | 2013 | 136 |
33 | Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury | American Journal of Pathology | 2013 | 134 |
34 | Neutrophil-mediated tissue injury in alcoholic hepatitis | Alcohol | 2002 | 133 |
35 | Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse | Toxicology and Applied Pharmacology | 2004 | 133 |
36 | Acetaminophen Toxicity in Mice Lacking NADPH Oxidase Activity: Role of Peroxynitrite Formation and Mitochondrial Oxidant Stress | Free Radical Research | 2003 | 131 |
37 | Manganese porphyrin given at symptom onset markedly extends survival of ALS mice | Annals of Neurology | 2005 | 131 |
38 | Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 2002 | 126 |
39 | Effects of CXC chemokines on neutrophil activation and sequestration in hepatic vasculature | American Journal of Physiology - Renal Physiology | 2001 | 124 |
40 | Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors | Journal of Pharmacology and Experimental Therapeutics | 2005 | 124 |
41 | Vascular calcium channels and high blood pressure: Pathophysiology and therapeutic implications | Vascular Pharmacology | 2006 | 122 |
42 | Dietary Soy Protein Isolate Attenuates Metabolic Syndrome in Rats via Effects on PPAR, LXR, and SREBP Signaling | Journal of Nutrition | 2009 | 122 |
43 | Immunotherapy for the treatment of drug abuse | Journal of Nutrition | 2005 | 121 |
44 | Protection against Fas Receptor-Mediated Apoptosis in Hepatocytes and Nonparenchymal Cells by a Caspase-8 Inhibitor in Vivo: Evidence for a Postmitochondrial Processing of Caspase-8 | Toxicological Sciences | 2000 | 116 |
45 | Evidence for the Role of Reactive Nitrogen Species in Polymicrobial Sepsis-Induced Renal Peritubular Capillary Dysfunction and Tubular Injury | Journal of the American Society of Nephrology: JASN | 2007 | 116 |
46 | Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse? | Molecular Interventions: Pharmacological Perspectives From Biology, Chemistry and Genomics | 2011 | 116 |
47 | Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine | Journal of Pharmacology and Experimental Therapeutics | 2000 | 113 |
48 | Manganese-induced reactive oxygen species: Comparison between Mn+2 and Mn+3 | Experimental Neurology | 1995 | 111 |
49 | Scavenging Peroxynitrite with Glutathione Promotes Regeneration and Enhances Survival during Acetaminophen-Induced Liver Injury in Mice | Journal of Pharmacology and Experimental Therapeutics | 2003 | 111 |
50 | Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice | American Journal of Physiology - Renal Physiology | 2007 | 111 |